دورية أكاديمية
Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern.
| العنوان: | Isolation of a panel of ultra-potent human antibodies neutralizing SARS-CoV-2 and viral variants of concern. |
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| المؤلفون: | Gorchakov AA; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Kulemzin SV; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Guselnikov SV; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Baranov KO; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Belovezhets TN; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Mechetina LV; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.; Novosibirsk State University, Novosibirsk, Russia., Volkova OY; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Najakshin AM; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Chikaev NA; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Chikaev AN; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Solodkov PP; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia., Larichev VF; National Research Center of Epidemiology and Microbiology named after the honorary academician N.F. Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russia., Gulyaeva MA; Novosibirsk State University, Novosibirsk, Russia.; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia., Markhaev AG; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia., Kononova YV; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia., Alekseyev AY; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.; Dagestan State University, Makhachkala, Republic of Dagestan, Russia., Shestopalov AM; Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.; Dagestan State University, Makhachkala, Republic of Dagestan, Russia., Yusubalieva GM; Federal Research and Clinical Center for Specialized Medical Care, FMBA of Russia, Moscow, Russia., Klypa TV; Federal Research and Clinical Center for Specialized Medical Care, FMBA of Russia, Moscow, Russia., Ivanov AV; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Valuev-Elliston VT; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia., Baklaushev VP; Federal Research and Clinical Center for Specialized Medical Care, FMBA of Russia, Moscow, Russia., Taranin AV; Institute of Molecular and Cellular Biology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. taranin@mcb.nsc.ru. |
| المصدر: | Cell discovery [Cell Discov] 2021 Oct 19; Vol. 7 (1), pp. 96. Date of Electronic Publication: 2021 Oct 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101661034 Publication Model: Electronic Cited Medium: Print ISSN: 2056-5968 (Print) Linking ISSN: 20565968 NLM ISO Abbreviation: Cell Discov Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : Nature Publishing Group, [2015]- |
| مستخلص: | In the absence of virus-targeting small-molecule drugs approved for the treatment and prevention of COVID-19, broadening the repertoire of potent SARS-CoV-2-neutralizing antibodies represents an important area of research in response to the ongoing pandemic. Systematic analysis of such antibodies and their combinations can be particularly instrumental for identification of candidates that may prove resistant to the emerging viral escape variants. Here, we isolated a panel of 23 RBD-specific human monoclonal antibodies from the B cells of convalescent patients. A surprisingly large proportion of such antibodies displayed potent virus-neutralizing activity both in vitro and in vivo. Four of the isolated nAbs can be categorized as ultrapotent with an apparent IC (© 2021. The Author(s).) |
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| تواريخ الأحداث: | Date Created: 20211020 Latest Revision: 20240403 |
| رمز التحديث: | 20240403 |
| مُعرف محوري في PubMed: | PMC8526700 |
| DOI: | 10.1038/s41421-021-00340-8 |
| PMID: | 34667147 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2056-5968 |
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| DOI: | 10.1038/s41421-021-00340-8 |