دورية أكاديمية
Early diagnosis of aspergillosis in asthmatic and rheumatoid arthritis patients by Aspergillus galactomannan antigen assay: a case-control study in Karbala providence.
| العنوان: | Early diagnosis of aspergillosis in asthmatic and rheumatoid arthritis patients by Aspergillus galactomannan antigen assay: a case-control study in Karbala providence. |
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| المؤلفون: | Al-Janabi AAHS; Department of Microbiology, College of Medicine, University of Karbala, Karbala, Iraq., Ali RN; Department of Microbiology, College of Medicine, University of Karbala, Karbala, Iraq. |
| المصدر: | The Journal of asthma : official journal of the Association for the Care of Asthma [J Asthma] 2022 Nov; Vol. 59 (11), pp. 2276-2282. Date of Electronic Publication: 2021 Nov 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 8106454 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4303 (Electronic) Linking ISSN: 02770903 NLM ISO Abbreviation: J Asthma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: [Ossining, N.Y. : Asthma Publications Society, c1981- |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid*/complications , Aspergillosis*/diagnosis , Asthma*/complications , Asthma*/diagnosis, Aspergillus ; Case-Control Studies ; Early Diagnosis ; Enzyme-Linked Immunosorbent Assay ; Female ; Galactose/analogs & derivatives ; Humans ; Male ; Mannans ; Middle Aged ; Sensitivity and Specificity |
| مستخلص: | Objective: Aspergillosis is an opportunistic systemic infection caused by members of Aspergillus spp. in various parts of the human body. Chronic diseases such as rheumatoid arthritis (RA) and asthma may encourage the development of aspergillosis under specific conditions. Thus, aspergillosis was investigated in patients with RA and asthma based on detection of galactomannan antigen. Methods: A case-control study was performed to involve 184 subjects, distributing in four groups: 55 patients with RA, 54 with asthma, 27 with both RA and asthma, and 48 healthy individuals. Serum was collected from involved subjects for detection of human Aspergillus galactomannan by ELISA. The optical density index (ODI) at cutoff <0.5 was used to determine the infection. Results: Aspergillosis was more frequently diagnosed in females with RA and both RA and asthma in opposite to the males. It also was found in most common in middle-aged subjects. There was no significant difference in measurement of GM between all patient groups and healthy individuals. Conclusion: Aspergillosis can develop in either immunocompetent or immunocompromised individuals. Patients with either RA or RA and asthma are more susceptible to acquired aspergillosis than those with only one disease. Application of GM for diagnosis of aspergillosis may show a nonsignificant results when it uses alone and needs other investigation tests. |
| فهرسة مساهمة: | Keywords: Aspergillosis; ELISA; asthma; galactomannan; rheumatoid arthritis |
| المشرفين على المادة: | 0 (Mannans) 11078-30-1 (galactomannan) X2RN3Q8DNE (Galactose) |
| تواريخ الأحداث: | Date Created: 20211020 Date Completed: 20221019 Latest Revision: 20221222 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/02770903.2021.1996601 |
| PMID: | 34669546 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1532-4303 |
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| DOI: | 10.1080/02770903.2021.1996601 |