دورية أكاديمية
Molecular Magnetic Resonance Imaging of Vascular Inflammation After Recanalization in a Rat Ischemic Stroke Model.
| العنوان: | Molecular Magnetic Resonance Imaging of Vascular Inflammation After Recanalization in a Rat Ischemic Stroke Model. |
|---|---|
| المؤلفون: | Franx BAA; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, the Netherlands (B.A.A.F., A.V.d.T., C.V.H., T.B., R.M.D.)., Van der Toorn A; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, the Netherlands (B.A.A.F., A.V.d.T., C.V.H., T.B., R.M.D.)., Van Heijningen C; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, the Netherlands (B.A.A.F., A.V.d.T., C.V.H., T.B., R.M.D.)., Vivien D; Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute Blood and Brain @ Caen-Normandie (BB@C), France (D.V., T.B.).; CHU Caen, Department of Clinical Research, CHU Caen Côte de Nacre, France (D.V.)., Bonnard T; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, the Netherlands (B.A.A.F., A.V.d.T., C.V.H., T.B., R.M.D.).; Normandie University, UNICAEN, INSERM UMR-S U1237, Physiopathology and Imaging of Neurological Disorders (PhIND), Institute Blood and Brain @ Caen-Normandie (BB@C), France (D.V., T.B.)., Dijkhuizen RM; Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences, University Medical Center Utrecht and Utrecht University, the Netherlands (B.A.A.F., A.V.d.T., C.V.H., T.B., R.M.D.). |
| المصدر: | Stroke [Stroke] 2021 Dec; Vol. 52 (12), pp. e788-e791. Date of Electronic Publication: 2021 Oct 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0235266 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4628 (Electronic) Linking ISSN: 00392499 NLM ISO Abbreviation: Stroke Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1998- : Baltimore, Md. : Lippincott Williams & Wilkins Original Publication: Dallas : American Heart Association |
| مواضيع طبية MeSH: | Infarction, Middle Cerebral Artery/*pathology , Magnetic Resonance Imaging/*methods , Neuroinflammatory Diseases/*pathology , Vasculitis/*pathology, Animals ; Disease Models, Animal ; Endovascular Procedures ; Infarction, Middle Cerebral Artery/surgery ; Male ; Rats ; Rats, Sprague-Dawley ; Thrombectomy |
| مستخلص: | Background and Purpose: Brain imaging has become central in the management of acute ischemic stroke. Detection of parenchymal injury and perfusion enables characterization of the extent of ischemic damage, which guides treatment decision-making. Additional assessment of secondary events, such as inflammation, which may particularly arise after recanalization, may improve diagnosis and (supplementary) treatment selection. Therefore, we developed and tested a molecular magnetic resonance imaging (MRI) approach for in vivo detection of vascular inflammation after transient middle cerebral artery occlusion in rats. Methods: Molecular MRI of VCAM-1 (vascular cell adhesion molecule-1) expression was performed with a targeted contrast agent, in addition to MR angiography, and diffusion-, T Results: VCAM-1 expression, detected with susceptibility-weighted MRI, was significantly enhanced at 6 hours after recanalization as compared with 1-hour postrecanalization, coinciding with a transient decline in perfusion after initial hyperperfusion. VCAM-1 levels declined after 24 hours, but remained elevated, particularly in lesion borderzones. Conclusions: The implementation of molecular MRI of vascular inflammation into imaging protocols after acute ischemic stroke could provide complementary information that may guide treatment decision-making before and after recanalization therapy. |
| فهرسة مساهمة: | Keywords: cell adhesion; inflammation; ischemic stroke; magnetic resonance imaging; perfusion |
| تواريخ الأحداث: | Date Created: 20211022 Date Completed: 20220107 Latest Revision: 20220107 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1161/STROKEAHA.121.034910 |
| PMID: | 34674544 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1524-4628 |
|---|---|
| DOI: | 10.1161/STROKEAHA.121.034910 |