دورية أكاديمية
أعرض في EDS

A Systematic Review of Focal Cartilage Defect Treatments in Middle-Aged Versus Younger Patients.

التفاصيل البيبلوغرافية
العنوان: A Systematic Review of Focal Cartilage Defect Treatments in Middle-Aged Versus Younger Patients.
المؤلفون: Jeuken RM; Maastricht University Medical Center, Maastricht, the Netherlands., van Hugten PPW; Maastricht University Medical Center, Maastricht, the Netherlands., Roth AK; Maastricht University Medical Center, Maastricht, the Netherlands., Timur UT; Maastricht University Medical Center, Maastricht, the Netherlands., Boymans TAEJ; Maastricht University Medical Center, Maastricht, the Netherlands., van Rhijn LW; Maastricht University Medical Center, Maastricht, the Netherlands., Bugbee WD; Department of Orthopaedic Surgery, Scripps Clinic, La Jolla, California, USA., Emans PJ; Maastricht University Medical Center, Maastricht, the Netherlands.
المصدر: Orthopaedic journal of sports medicine [Orthop J Sports Med] 2021 Oct 15; Vol. 9 (10), pp. 23259671211031244. Date of Electronic Publication: 2021 Oct 15 (Print Publication: 2021).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Sage on behalf of: The American Orthopaedic Society for Sports Medicine Country of Publication: United States NLM ID: 101620522 Publication Model: eCollection Cited Medium: Print ISSN: 2325-9671 (Print) Linking ISSN: 23259671 NLM ISO Abbreviation: Orthop J Sports Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Thousand Oaks, CA] : Sage on behalf of: The American Orthopaedic Society for Sports Medicine, [2013]-
مستخلص: Background: Focal cartilage defects are often debilitating, possess limited potential for regeneration, are associated with increased risk of osteoarthritis, and are predictive for total knee arthroplasty. Cartilage repair studies typically focus on the outcome in younger patients, but a high proportion of treated patients are 40 to 60 years of age (ie, middle-aged). The reality of current clinical practice is that the ideal patient for cartilage repair is not the typical patient. Specific attention to cartilage repair outcomes in middle-aged patients is warranted.
Purpose: To systematically review available literature on knee cartilage repair in middle-aged patients and include studies comparing results across different age groups.
Study Design: Systematic review; Level of evidence, 4.
Methods: A systematic search was performed in EMBASE, MEDLINE, and the Cochrane Library database. Articles were screened for relevance and appraised for quality.
Results: A total of 21 articles (mean Coleman Methodology Score, 64 points) were included. Two out of 3 bone marrow stimulation (BMS) studies, including 1 using the microfracture technique, revealed inferior clinical outcomes in middle-aged patients in comparison with younger patients. Nine cell-based studies were included showing inconsistent comparisons of results across age groups for autologous chondrocyte implantation (ACI). Bone marrow aspirate concentrate showed age-independent results at up to 8 years of follow-up. A negative effect of middle age was reported in 1 study for both ACI and BMS. Four out of 5 studies on bone-based resurfacing therapies (allografting and focal knee resurfacing implants [FKRIs]) showed age-independent results up to 5 years. One study in only middle-aged patients reported better clinical outcomes for FKRIs when compared with biological repairs.
Conclusion: Included studies were heterogeneous and had low methodological quality. BMS in middle-aged patients seems to only result in short-term improvements. More research is warranted to elucidate the ameliorating effects of cell-based therapies on the aging joint homeostasis. Bone-based therapies seem to be relatively insensitive to aging and may potentially result in effective joint preservation. Age subanalyses in cohort studies, randomized clinical trials, and international registries should generate more evidence for the large but underrepresented (in terms of cartilage repair) middle-aged population in the literature.
Competing Interests: One or more of the authors has declared the following potential conflict of interest or source of funding: W.D.B. has received consulting fees from JRF Ortho and Arthrex. P.J.E. has received consulting fees from Episurf and KioMed. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto.
(© The Author(s) 2021.)
References: Knee Surg Sports Traumatol Arthrosc. 2010 Apr;18(4):434-47. (PMID: 20130833)
J Arthroplasty. 2015 Apr;30(4):592-4. (PMID: 25443361)
Mech Ageing Dev. 2008 Mar;129(3):163-73. (PMID: 18241911)
Am J Sports Med. 2014 Apr;42(4):898-905. (PMID: 24481827)
Am J Sports Med. 2017 Jul;45(8):1822-1828. (PMID: 28333539)
Knee Surg Sports Traumatol Arthrosc. 2019 Jun;27(6):1739-1753. (PMID: 30721344)
Cartilage. 2010 Oct;1(4):312-9. (PMID: 26069562)
J Trauma. 2005 Jan;58(1):62-9. (PMID: 15674152)
Knee Surg Sports Traumatol Arthrosc. 2018 Jul;26(7):2196-2204. (PMID: 29167954)
Knee Surg Sports Traumatol Arthrosc. 2019 May;27(5):1693-1697. (PMID: 30756129)
Arch Orthop Trauma Surg. 2011 Mar;131(3):283-91. (PMID: 20082085)
Cartilage. 2020 Oct 27;:1947603520967064. (PMID: 33106003)
Am J Sports Med. 2005 Mar;33(3):443-60. (PMID: 15716263)
Am J Sports Med. 2010 Feb;38(2):231-7. (PMID: 20042546)
Arthroscopy. 2016 Oct;32(10):2110-2117. (PMID: 27234650)
Am J Sports Med. 2010 Jun;38(6):1110-6. (PMID: 20392971)
Nat Rev Rheumatol. 2015 Jan;11(1):21-34. (PMID: 25247412)
Am J Sports Med. 2014 Jun;42(6):1426-32. (PMID: 24664138)
Knee. 2015 Oct;22(5):446-9. (PMID: 26116040)
Biomacromolecules. 2019 May 13;20(5):2034-2042. (PMID: 31009565)
Am J Sports Med. 2006 Jan;34(1):128-35. (PMID: 16219941)
Scand J Med Sci Sports. 2000 Feb;10(1):2-11. (PMID: 10693606)
Orthop J Sports Med. 2018 Nov 15;6(11):2325967118805441. (PMID: 30480011)
Am J Sports Med. 2018 Jan;46(1):181-191. (PMID: 29140738)
Lancet. 2017 Apr 8;389(10077):1424-1430. (PMID: 28209371)
Knee Surg Sports Traumatol Arthrosc. 2014 Sep;22(9):2070-5. (PMID: 23896943)
Arthroscopy. 2019 Jan;35(1):138-146. (PMID: 30473458)
Clin Orthop Surg. 2019 Sep;11(3):282-290. (PMID: 31475048)
Clin Orthop Relat Res. 2013 Jan;471(1):231-7. (PMID: 22961315)
Arthrosc Tech. 2017 Sep 18;6(5):e1613-e1618. (PMID: 29399444)
Injury. 2011 Jun;42(6):551-5. (PMID: 21489527)
J Knee Surg. 2020 May 29;:. (PMID: 32483798)
Arthroscopy. 2013 Jul;29(7):1243-1252.e5. (PMID: 23623292)
Am J Sports Med. 2018 Mar;46(3):581-589. (PMID: 29185781)
Acta Orthop Traumatol Turc. 2016 Oct;50(5):533-538. (PMID: 27876261)
Am J Sports Med. 2018 Mar;46(3):642-648. (PMID: 29144772)
Knee Surg Sports Traumatol Arthrosc. 2014 Feb;22(2):363-78. (PMID: 23775341)
Arch Orthop Trauma Surg. 2013 Jan;133(1):87-93. (PMID: 23070222)
Arthroscopy. 2015 Mar;31(3):396-403. (PMID: 25498871)
Cartilage. 2019 Jan;10(1):70-81. (PMID: 28573889)
Cartilage. 2013 Jul;4(3 Suppl):5S-12S. (PMID: 26069664)
Tissue Eng Part B Rev. 2019 Apr;25(2):114-125. (PMID: 30638141)
Knee Surg Sports Traumatol Arthrosc. 2012 Mar;20(3):401-6. (PMID: 22068268)
Am J Sports Med. 2016 Sep;44(9):2354-65. (PMID: 27358284)
Am J Sports Med. 2019 Jun;47(7):1621-1628. (PMID: 31095402)
Theranostics. 2018 Oct 5;8(18):5039-5058. (PMID: 30429885)
Knee Surg Sports Traumatol Arthrosc. 2017 Aug;25(8):2494-2501. (PMID: 26768608)
Knee. 2007 Jun;14(3):177-82. (PMID: 17428666)
J Bone Joint Surg Am. 2019 Jan 2;101(1):56-63. (PMID: 30601416)
Am J Sports Med. 2010 Dec;38(12):2410-6. (PMID: 20829417)
Arch Orthop Trauma Surg. 2017 Sep;137(9):1307-1317. (PMID: 28526923)
J Bone Joint Surg Am. 2009 Jul;91(7):1778-90. (PMID: 19571102)
JB JS Open Access. 2017 Apr 06;2(2):e0011. (PMID: 30229214)
J Bone Joint Surg Am. 2010 Oct 20;92(14):2470-90. (PMID: 20962200)
J Arthroplasty. 2018 Aug;33(8):2435-2439. (PMID: 29705680)
Am J Sports Med. 2009 May;37(5):902-8. (PMID: 19261905)
Cartilage. 2018 Apr;9(2):161-170. (PMID: 29126349)
Orthop Traumatol Surg Res. 2011 Dec;97(8 Suppl):S140-53. (PMID: 22036244)
Knee Surg Sports Traumatol Arthrosc. 2018 Apr;26(4):1044-1052. (PMID: 29128878)
J Arthroplasty. 2021 Mar;36(3):917-921. (PMID: 33051122)
Syst Rev. 2016 Dec 5;5(1):210. (PMID: 27919275)
Dis Model Mech. 2018 Jun 19;11(6):. (PMID: 29728409)
Acta Biomater. 2019 Jan 15;84:1-15. (PMID: 30445157)
Am J Sports Med. 2012 Feb;40(2):325-31. (PMID: 22056348)
Acta Orthop. 2016 Dec;87(sup363):6-14. (PMID: 27658487)
Am J Sports Med. 2016 Feb;44(2):409-16. (PMID: 26657570)
Arthroscopy. 2006 Nov;22(11):1180-6. (PMID: 17084294)
J Bone Joint Surg Br. 2006 Jan;88(1):61-4. (PMID: 16365122)
Orthop J Sports Med. 2014 Sep 18;2(9):2325967114550276. (PMID: 26535363)
Arthroscopy. 2017 Feb;33(2):364-373. (PMID: 27663035)
Arch Orthop Trauma Surg. 2013 Apr;133(4):531-6. (PMID: 23329302)
Arthritis Rheum. 2012 Feb;64(2):339-41. (PMID: 22252374)
Knee Surg Sports Traumatol Arthrosc. 2021 Sep;29(9):2899-2910. (PMID: 33025052)
Calcif Tissue Int. 2021 Sep;109(3):329-338. (PMID: 32367210)
J Bone Joint Surg Br. 2010 Apr;92(4):508-12. (PMID: 20357326)
Am J Sports Med. 2009 Nov;37 Suppl 1:58S-62S. (PMID: 19934438)
Eur J Radiol. 2006 Jan;57(1):3-8. (PMID: 16188418)
Sci Rep. 2018 Apr 12;8(1):5931. (PMID: 29651151)
Arthroscopy. 2014 Feb;30(2):222-6. (PMID: 24485115)
J Clin Orthop Trauma. 2016 Jul-Sep;7(3):145-52. (PMID: 27489408)
Bone Joint J. 2015 Feb;97-B(2):197-201. (PMID: 25628282)
Am J Sports Med. 2014 Mar;42(3):648-57. (PMID: 24458240)
فهرسة مساهمة: Keywords: bone marrow stimulation; bone-based; cartilage; cell-based; middle-aged; repair
تواريخ الأحداث: Date Created: 20211022 Latest Revision: 20220427
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8524698
DOI: 10.1177/23259671211031244
PMID: 34676269
قاعدة البيانات: MEDLINE
الوصف
تدمد:2325-9671
DOI:10.1177/23259671211031244