دورية أكاديمية
أعرض في EDS

Banff consensus recommendations for steatosis assessment in donor livers.

التفاصيل البيبلوغرافية
العنوان: Banff consensus recommendations for steatosis assessment in donor livers.
المؤلفون: Neil DAH; Department of Cellular PathologyQueen Elizabeth Hospital BirminghamBirminghamUK.; Institute of Immunology and ImmunotherapyUniversity of BirminghamBirminghamUK., Minervini M; Division of Transplant PathologyUniversity of Pittsburgh Medical CentrePittsburghPennsylvaniaUSA., Smith ML; Department of Pathology and Laboratory MedicineMayo Clinic ArizonaScottsdaleArizonaUSA., Hubscher SG; Department of Cellular PathologyQueen Elizabeth Hospital BirminghamBirminghamUK.; Institute of Immunology and ImmunotherapyUniversity of BirminghamBirminghamUK., Brunt EM; Department of Pathology and ImmunologyWashington University School of MedicineSt LouisMissouriUSA., Demetris AJ; Division of Transplant PathologyUniversity of Pittsburgh Medical CentrePittsburghPennsylvaniaUSA.; Division of Liver and Transplantation PathologyUniversity of PittsburghPittsburghPennsylvaniaUSA.
المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2022 Apr; Vol. 75 (4), pp. 1014-1025. Date of Electronic Publication: 2021 Dec 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [Philadelphia] : Wolters Kluwer Health, Inc.
Original Publication: Baltimore, MD : Williams & Wilkins, [c1981]-
مواضيع طبية MeSH: Fatty Liver*/diagnosis , Fatty Liver*/pathology , Liver Transplantation*/methods, Biopsy ; Consensus ; Humans ; Liver/pathology ; Living Donors ; Tissue Donors
مستخلص: Background and Aims: No consensus criteria or approaches exist regarding assessment of steatosis in the setting of human donor liver suitability for transplantation. The Banff Working Group on Liver Allograft Pathology undertook a study to determine the consistency with which steatosis is assessed and reported in frozen sections of potential donor livers.
Approach and Results: A panel of 59 pathologists from 16 countries completed a questionnaire covering criteria used to assess steatosis in donor liver biopsies, including droplet size and magnification used; subsequently, steatosis severity was assessed in 18 whole slide images of donor liver frozen sections (n = 59). Survey results (from 56/59) indicated a wide variation in definitions and approaches used to assess and report steatosis. Whole slide image assessment led to a broad range in the scores. Findings were discussed at a workshop held at the 15th Banff Conference on Allograft Pathology, September 2019. The aims of discussions were to (i) establish consensus criteria for defining "large droplet fat" (LDF) that predisposes to increased risk of initial poor graft function and (ii) develop an algorithmic approach to determine fat droplet size and the percentage of hepatocytes involved. LDF was defined as typically a single fat droplet that expands the involved hepatocyte and is larger than adjacent nonsteatotic hepatocytes. Estimating severity of steatosis involves (i) low magnification estimate of the approximate surface area of the biopsy occupied by fat, (ii) higher magnification determination of the percentage of hepatocytes within the fatty area with LDF, and (iii) final score calculation.
Conclusions: The proposed guidelines herein are intended to improve standardization in steatosis assessment of donor liver biopsies. The calculated percent LDF should be provided to the surgeon.
(© 2021 The Authors. Hepatology published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.)
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تواريخ الأحداث: Date Created: 20211022 Date Completed: 20220502 Latest Revision: 20230309
رمز التحديث: 20230309
مُعرف محوري في PubMed: PMC9299655
DOI: 10.1002/hep.32208
PMID: 34676901
قاعدة البيانات: MEDLINE
الوصف
تدمد:1527-3350
DOI:10.1002/hep.32208