Do Fetal Microchimeric Cells Influence Experimental Autoimmune Myocarditis?

التفاصيل البيبلوغرافية
العنوان:	Do Fetal Microchimeric Cells Influence Experimental Autoimmune Myocarditis?
المؤلفون:	Ribeiro RSA; Department of Immunobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil.; Graduate Program in Pathology, Federal Fluminense University, Niterói, Brazil., Demarque KC; Cell Biology Laboratory, Oswaldo Cruz Institute/FIOCRUZ, Rio de Janeiro, Brazil., Figueiredo Júnior I; Maternal and Child Department, Antônio Pedro University Hospital, Federal Fluminense University, Niterói, Brazil., Ferreira IMDESR; Department of Immunobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil., Valeriano JDP; Department of Immunobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil.; Graduate Program in Pathology, Federal Fluminense University, Niterói, Brazil., Verícimo MA; Department of Immunobiology, Institute of Biology, Federal Fluminense University, Niterói, Brazil.; Graduate Program in Pathology, Federal Fluminense University, Niterói, Brazil.
المصدر:	Fetal and pediatric pathology [Fetal Pediatr Pathol] 2022 Oct; Vol. 41 (5), pp. 781-793. Date of Electronic Publication: 2021 Oct 22.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Informa Healthcare Country of Publication: England NLM ID: 101230972 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1551-3823 (Electronic) Linking ISSN: 15513815 NLM ISO Abbreviation: Fetal Pediatr Pathol Subsets: MEDLINE
أسماء مطبوعة:	Publication: London : Informa Healthcare Original Publication: Philadelphia, PA : Taylor & Francis, c2004-
مواضيع طبية MeSH:	Autoimmune Diseases/prevention & control , Myocarditis, Animals ; Cardiac Myosins ; Female ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Myocardium ; Peptides
مستخلص:	Objective: We investigated the presence and influence of fetal microchimerism in the cardiac tissue of mated female mice submitted to experimental autoimmune myocarditis. Materials and methods: Nulliparous BALB/c females and BALB/c females mated with either BALB/c males (syngeneic mating) or C57BL/6 males (allogeneic mating) were immunized with cardiac myosin peptide MyHC-α 614-629 or kept as non-immunized controls. Immunization occurred 6-8 weeks after delivery and mice were assessed after 21 days. Results: Immunized mice of allogeneic mating had a lower production of anti-MyHC-α 614-629 antibodies compared to immunized nulliparous mice. Immunized nulliparous females had an intense mononuclear inflammatory infiltrate in cardiac tissue, associated with fibroplasia, while mated females had a lower inflammatory reaction. An increase in the frequency of microchimeric fetal cells was observed in mice submitted to allogeneic mating following immunization. Conclusion: Allogeneic cells of fetal origin could contribute to mitigating the inflammatory response in experimental myocarditis.
فهرسة مساهمة:	Keywords: Pregnancy; fetal cells; microchimerism; myocarditis; semi-allogeneic cells
المشرفين على المادة:	0 (Peptides) EC 3.6.1.- (Cardiac Myosins)
تواريخ الأحداث:	Date Created: 20211022 Date Completed: 20220928 Latest Revision: 20220928
رمز التحديث:	20231215
DOI:	10.1080/15513815.2021.1994067
PMID:	34678109
قاعدة البيانات:	MEDLINE

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الوصف
تدمد:	1551-3823
DOI:	10.1080/15513815.2021.1994067