دورية أكاديمية
أعرض في EDS

Association of PIP4K2A Polymorphisms with Alcohol Use Disorder.

التفاصيل البيبلوغرافية
العنوان: Association of PIP4K2A Polymorphisms with Alcohol Use Disorder.
المؤلفون: Fedorenko OY; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.; Division for Control and Diagnostics, School of Non-Destructive Testing and Security, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia., Mikhalitskaya EV; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Toshchakova VA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia., Loonen AJM; PharmacoTherapy, Epidemiology and Economics, Groningen Research Institute of Pharmacy, University of Groningen, 9713AV Groningen, The Netherlands., Bokhan NA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.; Department of Psychotherapy and Psychological Counseling, National Research Tomsk State University, 634050 Tomsk, Russia.; Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, 634050 Tomsk, Russia., Ivanova SA; Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, 634014 Tomsk, Russia.; Division for Control and Diagnostics, School of Non-Destructive Testing and Security, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia.; Department of Psychiatry, Addictology and Psychotherapy, Siberian State Medical University, 634050 Tomsk, Russia.
المصدر: Genes [Genes (Basel)] 2021 Oct 19; Vol. 12 (10). Date of Electronic Publication: 2021 Oct 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101551097 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4425 (Electronic) Linking ISSN: 20734425 NLM ISO Abbreviation: Genes (Basel) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel : MDPI
مواضيع طبية MeSH: Genetic Predisposition to Disease* , Genome-Wide Association Study*, Alcoholism/*genetics , Phosphotransferases (Alcohol Group Acceptor)/*genetics, Adolescent ; Adult ; Alcohol Drinking/epidemiology ; Alcohol Drinking/genetics ; Alcohol Drinking/physiopathology ; Alcoholism/epidemiology ; Alcoholism/pathology ; Alleles ; Female ; Genotype ; Humans ; Male ; Middle Aged ; Risk Factors ; Russia/epidemiology ; Young Adult
مستخلص: Background: Alcohol use disorder (AUD) not only influences individuals and families but also has a lasting social impact on communities at the national level. Dopaminergic neurotransmission is involved in excessive alcohol consumption. Phosphatidylinositol-5-phosphate-4-kinase type 2 α (PIP4K2A) plays an important role in the regulation of ascending dopamine pathways. In this study; we determined possible associations between nine polymorphisms in PIP4K2A and AUD in Russian men.
Methods: 279 Russian men with AUD were investigated. The control group consisted of 222 healthy men from the general Russian population. Genotyping of DNA samples for nine polymorphic variants of PIP4K2A was carried out by the Applied Biosystems™ QuantStudio™ 5 Real-Time PCR System with use of the TaqMan1 Validated SNP Genotyping Assay (Applied Biosystems; CIIIA).
Results: Carriage of the PIP4K2A rs2230469*TT/T genotype/allele was a relative risk factor for developing AUD in men ( p = 0.026 and p = 0.0084 accordingly). Moreover; men with AUD had a higher frequency of PIP4K2A rs746203*T allele ( p = 0.023) compared to healthy men.
Conclusions: For the first time; we demonstrated different PIP4K2A polymorphisms to be associated with AUD presumably due to dopamine system modulation resulting from regulation of the lateral habenula.
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فهرسة مساهمة: Keywords: PIP4K2A; alcohol use disorder; polymorphisms
المشرفين على المادة: EC 2.7.1.- (PIP4K2A protein, human)
EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
تواريخ الأحداث: Date Created: 20211023 Date Completed: 20220208 Latest Revision: 20220208
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8535504
DOI: 10.3390/genes12101642
PMID: 34681036
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4425
DOI:10.3390/genes12101642