دورية أكاديمية
أعرض في EDS

The Effects of SRT1720 Treatment on Endothelial Cells Derived from the Lung and Bone Marrow of Young and Aged, Male and Female Mice.

التفاصيل البيبلوغرافية
العنوان: The Effects of SRT1720 Treatment on Endothelial Cells Derived from the Lung and Bone Marrow of Young and Aged, Male and Female Mice.
المؤلفون: Dadwal UC; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA., Bhatti FUR; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Awosanya OD; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Staut CA; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Nagaraj RU; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Perugini AJ 3rd; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Tewari NP; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Valuch CR; Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA., Sun S; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Mendenhall SK; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Zhou D; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Mostardo SL; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Blosser RJ; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA., Li J; Department of Biology, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA., Kacena MA; Department of Orthopaedic Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.; Richard L. Roudebush VA Medical Center, Indianapolis, IN 46202, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 14; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Aging/*physiology , Bone Marrow Cells/*drug effects , Heterocyclic Compounds, 4 or More Rings/*pharmacology , Lung/*cytology , Neovascularization, Physiologic/*drug effects, Angiopoietin-1/genetics ; Animals ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Endothelial Cells/drug effects ; Female ; Gene Expression Regulation/drug effects ; Male ; Mice, Inbred C57BL ; Neovascularization, Physiologic/physiology ; Sirtuin 1/genetics ; Vascular Endothelial Growth Factor Receptor-1/genetics ; Mice
مستخلص: Angiogenesis is critical for successful fracture healing. Age-related alterations in endothelial cells (ECs) may cause impaired bone healing. Therefore, examining therapeutic treatments to improve angiogenesis in aging may enhance bone healing. Sirtuin 1 (SIRT1) is highly expressed in ECs and its activation is known to counteract aging. Here, we examined the effects of SRT1720 treatment (SIRT1 activator) on the growth and function of bone marrow and lung ECs (BMECs and LECs, respectively), derived from young (3-4 month) and old (20-24 month) mice. While aging did not alter EC proliferation, treatment with SRT1720 significantly increased proliferation of all LECs. However, SRT1720 only increased proliferation of old female BMECs. Vessel-like tube assays showed similar vessel-like structures between young and old LECs and BMECs from both male and female mice. SRT1720 significantly improved vessel-like structures in all LECs. No age, sex, or treatment differences were found in migration related parameters of LECs. In males, old BMECs had greater migration rates than young BMECs, whereas in females, old BMECs had lower migration rates than young BMECs. Collectively, our data suggest that treatment with SRT1720 appears to enhance the angiogenic potential of LECs irrespective of age or sex. However, its role in BMECs is sex- and age-dependent.
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معلومات مُعتمدة: R01 AG060621 United States AG NIA NIH HHS; U54DK106846 United States NH NIH HHS; T32 HL007910 United States HL NHLBI NIH HHS; R01 AG060621 United States NH NIH HHS; U54 DK106846 United States DK NIDDK NIH HHS; T32 DK007519 United States NH NIH HHS; T32 DK007519 United States DK NIDDK NIH HHS; T32 HL007910 United States NH NIH HHS; CCEH award Cooperative Center of Excellence in Hematology; T32 AR065971 United States NH NIH HHS; BX003751 Richard L. Roudebush VA Medical Center; I01 BX003751 United States BX BLRD VA; T32 AR065971 United States AR NIAMS NIH HHS
فهرسة مساهمة: Keywords: Sirtuin 1; aging; angiogenesis; bone; endothelial cells; lungs
المشرفين على المادة: 0 (Angiopoietin-1)
0 (Angpt1 protein, mouse)
0 (Heterocyclic Compounds, 4 or More Rings)
0 (SRT1720)
EC 2.7.10.1 (Flt1 protein, mouse)
EC 2.7.10.1 (Vascular Endothelial Growth Factor Receptor-1)
EC 3.5.1.- (Sirt1 protein, mouse)
EC 3.5.1.- (Sirtuin 1)
تواريخ الأحداث: Date Created: 20211023 Date Completed: 20211227 Latest Revision: 20240226
رمز التحديث: 20240226
مُعرف محوري في PubMed: PMC8540697
DOI: 10.3390/ijms222011097
PMID: 34681756
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms222011097