دورية أكاديمية
أعرض في EDS

Placental Ischemia Says "NO" to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia.

التفاصيل البيبلوغرافية
العنوان: Placental Ischemia Says "NO" to Proper NOS-Mediated Control of Vascular Tone and Blood Pressure in Preeclampsia.
المؤلفون: Palei AC; Department of Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USA., Granger JP; Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA., Spradley FT; Department of Surgery, University of Mississippi Medical Center, Jackson, MS 39216, USA.; Department of Physiology & Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.; Department of Pharmacology & Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 19; Vol. 22 (20). Date of Electronic Publication: 2021 Oct 19.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Ischemia/*metabolism , Nitric Oxide/*metabolism , Nitric Oxide Synthase/*metabolism , Pre-Eclampsia/*metabolism, Animals ; Blood Pressure ; Female ; Humans ; Ischemia/blood ; Nitrates/blood ; Nitrites/blood ; Pre-Eclampsia/blood ; Pregnancy
مستخلص: In this review, we first provide a brief overview of the nitric oxide synthase (NOS) isoforms and biochemistry. This is followed by describing what is known about NOS-mediated blood pressure control during normal pregnancy. Circulating nitric oxide (NO) bioavailability has been assessed by measuring its metabolites, nitrite (NO 2 ) and/or nitrate (NO 3 ), and shown to rise throughout normal pregnancy in humans and rats and decline postpartum. In contrast, placental malperfusion/ischemia leads to systemic reductions in NO bioavailability leading to maternal endothelial and vascular dysfunction with subsequent development of hypertension in PE. We end this article by describing emergent risk factors for placental malperfusion and ischemic disease and discussing strategies to target the NOS system therapeutically to increase NO bioavailability in preeclamptic patients. Throughout this discussion, we highlight the critical importance that experimental animal studies have played in our current understanding of NOS biology in normal pregnancy and their use in finding novel ways to preserve this signaling pathway to prevent the development, treat symptoms, or reduce the severity of PE.
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معلومات مُعتمدة: R00HL130577 National Institute of Health; R56HL157579 National Institute of Health; R01 HL148191 United States HL NHLBI NIH HHS; P20 GM104357 United States GM NIGMS NIH HHS; P20GM104357 National Institute of Health; P01HL051971 National Institute of Health; U54GM115428 National Institute of Health; P20GM121334 National Institute of Health
فهرسة مساهمة: Keywords: intrauterine growth restriction; nitric oxide; nitric oxide synthases; potential therapies; preeclampsia; pregnancy
المشرفين على المادة: 0 (Nitrates)
0 (Nitrites)
31C4KY9ESH (Nitric Oxide)
EC 1.14.13.39 (Nitric Oxide Synthase)
تواريخ الأحداث: Date Created: 20211023 Date Completed: 20211213 Latest Revision: 20220521
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8541176
DOI: 10.3390/ijms222011261
PMID: 34681920
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms222011261