دورية أكاديمية
Relationships between retinopathy of prematurity without ophthalmologic intervention and neurodevelopment and vision at 2 years.
| العنوان: | Relationships between retinopathy of prematurity without ophthalmologic intervention and neurodevelopment and vision at 2 years. |
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| المؤلفون: | Brumbaugh JE; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA., Bell EF; Department of Pediatrics, University of Iowa, Iowa City, IA, USA. edward-bell@uiowa.edu., Hirsch SC; Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA., Crenshaw EG; Biostatistics and Epidemiology Division, RTI International, Research Triangle Park, NC, USA., DeMauro SB; Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA., Adams-Chapman IS; Department of Pediatrics, Emory University, Atlanta, GA, USA., Lowe JR; Department of Pediatrics, University of New Mexico, Albuquerque, NM, USA., Natarajan G; Department of Pediatrics, Wayne State University, Detroit, MI, USA., Wyckoff MH; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA., Vohr BR; Department of Pediatrics, Brown University, Providence, RI, USA., Colaizy TT; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Harmon HM; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Watterberg KL; Department of Pediatrics, University of New Mexico, Albuquerque, NM, USA., Hintz SR; Department of Pediatrics, Stanford University, Palo Alto, CA, USA. |
| مؤلفون مشاركون: | Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network |
| المصدر: | Pediatric research [Pediatr Res] 2023 Nov; Vol. 94 (5), pp. 1720-1730. Date of Electronic Publication: 2021 Oct 22. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 0100714 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0447 (Electronic) Linking ISSN: 00313998 NLM ISO Abbreviation: Pediatr Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2012- : New York : Nature Publishing Group Original Publication: Basel ; New York : Karger. |
| مواضيع طبية MeSH: | Retinopathy of Prematurity*/complications , Retinopathy of Prematurity*/diagnosis , Retinopathy of Prematurity*/epidemiology , Infant, Newborn, Diseases* , Strabismus*/complications, Infant, Newborn ; Infant ; Child ; Humans ; Infant, Premature ; Inositol ; Gestational Age |
| مستخلص: | Background: Severe retinopathy of prematurity (ROP) is associated with adverse outcomes. Relationships between milder ROP and outcomes have not been defined. We hypothesized that children with ROP stage ≤3 who did not receive ophthalmologic intervention would have worse motor, cognitive, and language skills and more vision abnormalities than children without ROP. Methods: This was a secondary analysis of a randomized trial evaluating the effects of myo-inositol on ROP in the NICHD Neonatal Research Network. Primary outcomes were Bayley Scales of Infant Development composite scores; secondary outcomes included behavioral difficulties and ophthalmologic measures. Outcomes were compared using adjusted linear or modified Poisson models. Results: Of 506 children, 173 (34%) had no ROP, 262 (52%) had ROP stage ≤3 without intervention, and 71 (14%) had ROP with intervention. There was no difference in motor, cognitive, or language scores between children with ROP stage ≤3 without intervention and children without ROP. Children with ROP stage ≤3 without intervention had a higher rate of strabismus compared to children without ROP (p = 0.040). Conclusion: Children with ROP stage ≤3 without intervention did not have adverse neurodevelopmental outcomes at 2 years' corrected age compared to children without ROP but did have an increased incidence of strabismus. Impact: This study addresses a gap in the literature regarding the relationship between milder forms of retinopathy of prematurity (ROP) that regress without intervention and neurodevelopment and vision outcomes. Children with a history of ROP stage ≤3 without intervention have similar neurodevelopmental outcomes at 2 years' corrected age as children born extremely preterm without a history of ROP and better outcomes than children with a history of ROP with ophthalmologic intervention. Counseling about likely neurodevelopment and vision outcomes for children born extremely preterm with a history of ROP may be tailored based on the severity of ROP. Clinical Trial Registration: ClinicalTrials.gov ID: Inositol to Reduce Retinopathy of Prematurity Trial: NCT01954082. (© 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.) |
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| معلومات مُعتمدة: | UG1 HD068263 United States HD NICHD NIH HHS; UG1 HD087226 United States HD NICHD NIH HHS; UG1 HD068270 United States HD NICHD NIH HHS; UG1 HD053089 United States HD NICHD NIH HHS; U10 HD027904 United States HD NICHD NIH HHS; UG1 HD027856 United States HD NICHD NIH HHS; UG1 HD034216 United States HD NICHD NIH HHS; UG1 HD027904 United States HD NICHD NIH HHS; UG1 HD027880 United States HD NICHD NIH HHS; UL1 TR001117 United States TR NCATS NIH HHS; UG1 HD053109 United States HD NICHD NIH HHS; UG1 HD027851 United States HD NICHD NIH HHS; U10 HD036790 United States HD NICHD NIH HHS; UG1 HD068244 United States HD NICHD NIH HHS; UG1 HD027853 United States HD NICHD NIH HHS; UG1 HD087229 United States HD NICHD NIH HHS; UG1 HD040689 United States HD NICHD NIH HHS; UG1 HD068284 United States HD NICHD NIH HHS; UG1 HD021385 United States HD NICHD NIH HHS; UG1 HD040492 United States HD NICHD NIH HHS; UG1 HD021364 United States HD NICHD NIH HHS; UG1 HD068278 United States HD NICHD NIH HHS; U24 HD095254 United States HD NICHD NIH HHS |
| سلسلة جزيئية: | ClinicalTrials.gov NCT01954082 |
| المشرفين على المادة: | 4L6452S749 (Inositol) |
| تواريخ الأحداث: | Date Created: 20211023 Date Completed: 20231106 Latest Revision: 20240323 |
| رمز التحديث: | 20240323 |
| مُعرف محوري في PubMed: | PMC9023615 |
| DOI: | 10.1038/s41390-021-01778-y |
| PMID: | 34686832 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1530-0447 |
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| DOI: | 10.1038/s41390-021-01778-y |