دورية أكاديمية

ZIKV Infection and miRNA Network in Pathogenesis and Immune Response.

التفاصيل البيبلوغرافية
العنوان: ZIKV Infection and miRNA Network in Pathogenesis and Immune Response.
المؤلفون: Polonio CM; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Laboratory of Neuroimmunology of Arboviruses, Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-020, Brazil., Peron JPS; Neuroimmune Interactions Laboratory, Department of Immunology, University of São Paulo, São Paulo 05508-000, Brazil.; Laboratory of Neuroimmunology of Arboviruses, Scientific Platform Pasteur-USP (SPPU), University of São Paulo, São Paulo 05508-020, Brazil.; Immunopathology and Allergy Post Graduate Program, School of Medicine, University of São Paulo, São Paulo 01246-000, Brazil.
المصدر: Viruses [Viruses] 2021 Oct 04; Vol. 13 (10). Date of Electronic Publication: 2021 Oct 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: MicroRNAs/*genetics , Zika Virus Infection/*genetics , Zika Virus Infection/*pathology, Animals ; Gene Regulatory Networks/genetics ; Humans ; Immunity/genetics ; Immunity/immunology ; MicroRNAs/metabolism ; Virus Replication/genetics ; Zika Virus/genetics ; Zika Virus/pathogenicity ; Zika Virus/physiology ; Zika Virus Infection/virology
مستخلص: Over the years, viral infections have caused severe illness in humans. Zika Virus (ZIKV) is a flavivirus transmitted by mosquito vectors that leads to notable neurological impairment, whose most dramatic impact is the Congenital ZIKV Syndrome (CZS). ZIKV targets neuronal precursor cells leading to apoptosis and further impairment of neuronal development, causing microcephaly, lissencephaly, ventriculomegaly, and calcifications. Several regulators of biological processes are involved in CZS development, and in this context, microRNAs (miRNAs) seem to have a fundamental role. miRNAs are important regulators of protein translation, as they form the RISC silencing complex and interact with complementary mRNA target sequences to further post-transcriptional repression. In this context, little is known about their participation in the pathogenesis of viral infections. In this review, we discuss how miRNAs could relate to ZIKV and other flavivirus infections.
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فهرسة مساهمة: Keywords: ZIKV; flavivirus; microRNAs; viral infection
المشرفين على المادة: 0 (MicroRNAs)
تواريخ الأحداث: Date Created: 20211026 Date Completed: 20220207 Latest Revision: 20220207
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8541119
DOI: 10.3390/v13101992
PMID: 34696422
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v13101992