دورية أكاديمية
أعرض في EDS

Rotavirus infection among children under five years of age hospitalized with acute gastroenteritis in Myanmar during 2018-2020 - Multicentre surveillance before rotavirus vaccine introduction.

التفاصيل البيبلوغرافية
العنوان: Rotavirus infection among children under five years of age hospitalized with acute gastroenteritis in Myanmar during 2018-2020 - Multicentre surveillance before rotavirus vaccine introduction.
المؤلفون: Myat TW; Department of Medical Research, Ministry of Health and Sports, Myanmar. Electronic address: drtheingiwinmyat@gmail.com., Thu HM; Department of Medical Research, Ministry of Health and Sports, Myanmar., Tate JE; Centers for Disease Control and Prevention, USA., Burnett E; Centers for Disease Control and Prevention, USA., Cates JE; Centers for Disease Control and Prevention, USA., Parashar UD; Centers for Disease Control and Prevention, USA., Kyaw YM; Yangon Children's Hospital, Ministry of Health and Sports, Myanmar., Khaing TEE; 550 Bedded Children's Hospital, Mandalay, Ministry of Health and Sports, Myanmar., Moh KM; Women and Children Hospital (Shan State, Taunggyi), Ministry of Health and Sports, Myanmar., Win NN; North Okkalapa General and Teaching Hospital, Ministry of Health and Sports, Myanmar., Khine WK; Department of Medical Research, Ministry of Health and Sports, Myanmar., Kham MMZ; Department of Medical Research, Ministry of Health and Sports, Myanmar., Kyaw T; Department of Medical Research, Ministry of Health and Sports, Myanmar., Khine YY; Department of Medical Research, Ministry of Health and Sports, Myanmar., Oo KK; Department of Medical Research, Ministry of Health and Sports, Myanmar., Aung KM; Department of Medical Research, Ministry of Health and Sports, Myanmar.
المصدر: Vaccine [Vaccine] 2021 Nov 16; Vol. 39 (47), pp. 6907-6912. Date of Electronic Publication: 2021 Oct 24.
نوع المنشور: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8406899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2518 (Electronic) Linking ISSN: 0264410X NLM ISO Abbreviation: Vaccine Subsets: MEDLINE
أسماء مطبوعة: Publication: Amsterdam, The Netherlands : Elsevier Science
Original Publication: [Guildford, Surrey, UK] : Butterworths, [c1983-
مواضيع طبية MeSH: Gastroenteritis*/epidemiology , Gastroenteritis*/prevention & control , Rotavirus*/genetics , Rotavirus Infections*/epidemiology , Rotavirus Infections*/prevention & control , Rotavirus Vaccines*, Child ; Child, Preschool ; Feces ; Genotype ; Hospitalization ; Humans ; Infant ; Male ; Myanmar/epidemiology ; Prospective Studies
مستخلص: Background: Rotavirus gastroenteritis (RVGE) is a leading cause of severe diarrhea in children under-five worldwide, with the majority of mortality in lower -income countries. This study aimed to provide baseline information on epidemiology of rotavirus and circulating strains before rotavirus vaccine introduction in Myanmar.
Methods: Hospital-based, prospective surveillance was conducted from May 2018 to January 2020 at four sentinel sites; two hospitals in Lower Myanmar, one hospital each in Middle Myanmar and East Myanmar. Children under five years of age hospitalized for acute gastroenteritis were enrolled; demographic and clinical data were collected. Stool samples were screened by ELISA (ProSpecT™ Rotavirus, OXOID-UK) for rotavirus antigen and a subset of ELISA positive samples were genotyped by reverse transcription polymerase chain reaction.
Results: Rotavirus was detected in 45.7% (799/1750) of cases enrolled at three sites in May 2018-April 2019 and 42.5% (521/1227) at four sites in May 2019-January 2020. RVGE cases were predominantly male (58.7%; 775/1320) and 92.6% (1223/1320) of RVGE cases occurred in <2 years old. Rotavirus detection was higher in the cold and dry season (November-April). RVGE compared to non-RVGE cases had more frequent vomiting (78.3% Vs 68.1%, p < 0.01), fever (65.8% Vs 61.3%, p = 0.01), severe dehydration (3.6% Vs 2.1%, p < 0.01) and requirement of treatment by IV fluid (58.3% Vs 53.1%, p < 0.01). The most prevalent genotypes identified were G1P[6] (113/359, 31.5%), G1P[8] (94/359, 26.2%) and G2P[4] (33/359, 9.2%).
Conclusions: This study confirms the persistent high prevalence of RVGE among children under-five admitted to hospitals in different parts of Myanmar and the diversity of rotavirus strains over time prior to vaccine introduction. The rotavirus vaccine was introduced nationwide in February 2020 in Myanmar and these data will be important baseline data for post-vaccination monitoring of vaccine impact and circulating strains.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Published by Elsevier Ltd.)
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معلومات مُعتمدة: CC999999 United States ImCDC Intramural CDC HHS
فهرسة مساهمة: Keywords: Myanmar; Rotavirus; Rotavirus Surveillance; Rotavirus genotypes; Rotavirus vaccine
المشرفين على المادة: 0 (Rotavirus Vaccines)
تواريخ الأحداث: Date Created: 20211027 Date Completed: 20220126 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC10862084
DOI: 10.1016/j.vaccine.2021.10.014
PMID: 34702620
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2518
DOI:10.1016/j.vaccine.2021.10.014