دورية أكاديمية
Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model.
| العنوان: | Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model. |
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| المؤلفون: | Rudar M; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.; Department of Animal Sciences, Auburn University, Auburn, Alabama., Naberhuis JK; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Suryawan A; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Nguyen HV; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Stoll B; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Style CC; The Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio., Verla MA; Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas., Olutoye OO; The Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, Ohio., Burrin DG; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Fiorotto ML; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas., Davis TA; United States Department of Agriculture/Agricultural Research Service Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas. |
| المصدر: | American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2021 Dec 01; Vol. 321 (6), pp. E737-E752. Date of Electronic Publication: 2021 Nov 01. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bethesda, MD. : American Physiological Society |
| مواضيع طبية MeSH: | Enteral Nutrition*/methods , Enteral Nutrition*/veterinary , Protein Biosynthesis*, Muscle, Skeletal/*growth & development, Animal Nutritional Physiological Phenomena ; Animals ; Animals, Newborn ; Cell Nucleus/metabolism ; Female ; Growth and Development/physiology ; Male ; Models, Animal ; Muscle Fibers, Skeletal/cytology ; Muscle Fibers, Skeletal/metabolism ; Muscle Proteins/metabolism ; Pregnancy ; Premature Birth ; Swine |
| مستخلص: | Optimizing enteral nutrition for premature infants may help mitigate extrauterine growth restriction and adverse chronic health outcomes. Previously, we showed in neonatal pigs born at term that lean growth is enhanced by intermittent bolus compared with continuous feeding. The objective was to determine if prematurity impacts how body composition, muscle protein synthesis, and myonuclear accretion respond to feeding modality. Following preterm delivery, pigs were fed equivalent amounts of formula delivered either as intermittent boluses (INT; n = 30) or continuously (CONT; n = 14) for 21 days. Body composition was measured by dual-energy X-ray absorptiometry (DXA) and muscle growth was assessed by morphometry, myonuclear accretion, and satellite cell abundance. Tissue anabolic signaling and fractional protein synthesis rates were determined in INT pigs in postabsorptive (INT-PA) and postprandial (INT-PP) states and in CONT pigs. Body weight gain and composition did not differ between INT and CONT pigs. Longissimus dorsi (LD) protein synthesis was 34% greater in INT-PP than INT-PA pigs ( P < 0.05) but was not different between INT-PP and CONT pigs. Phosphorylation of 4EBP1 and S6K1 and eIF4E·eIF4G abundance in LD paralleled changes in LD protein synthesis. Satellite cell abundance, myonuclear accretion, and fiber cross-sectional area in LD did not differ between groups. These results suggest that, unlike pigs born at term, intermittent bolus feeding does not enhance lean growth more than continuous feeding in pigs born preterm. Premature birth attenuates the capacity of skeletal muscle to respond to cyclical surges in insulin and amino acids with intermittent feeding in early postnatal life. NEW & NOTEWORTHY Extrauterine growth restriction often occurs in premature infants but may be mitigated by optimizing enteral feeding strategies. We show that intermittent bolus feeding does not increase skeletal muscle protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in preterm pigs. This attenuated anabolic response of muscle to intermittent bolus feeding, compared with previous observations in pigs born at term, may contribute to deficits in lean mass that many premature infants exhibit into adulthood. |
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| معلومات مُعتمدة: | HD-099080 HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); R01 HD099080 United States HD NICHD NIH HHS; HD-085573 HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); R01 HD072891 United States HD NICHD NIH HHS; R01 HD085573 United States HD NICHD NIH HHS; HD-072891 HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
| فهرسة مساهمة: | Keywords: feeding modality; myonuclear accretion; prematurity; protein synthesis; skeletal muscle |
| المشرفين على المادة: | 0 (Muscle Proteins) |
| تواريخ الأحداث: | Date Created: 20211101 Date Completed: 20220103 Latest Revision: 20220310 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8714968 |
| DOI: | 10.1152/ajpendo.00236.2021 |
| PMID: | 34719946 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1522-1555 |
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| DOI: | 10.1152/ajpendo.00236.2021 |