دورية أكاديمية
A new antimicrobial nor-friedelane-type triterpenoid and other constituents from Plectranthus glandulosus Hook. f. (Lamiaceae).
| العنوان: | A new antimicrobial nor-friedelane-type triterpenoid and other constituents from Plectranthus glandulosus Hook. f. (Lamiaceae). |
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| المؤلفون: | Tedonkeu AT; Natural Products Chemistry Research Unit, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Tamokou JD; Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Mpetga JDS; Natural Products Chemistry Research Unit, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Nzogong RT; Natural Products Chemistry Research Unit, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Kengne IC; Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon., Hao XJ; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China., Tene M; Natural Products Chemistry Research Unit, Department of Chemistry, Faculty of Science, University of Dschang, Dschang, Cameroon. |
| المصدر: | Natural product research [Nat Prod Res] 2022 Sep; Vol. 36 (18), pp. 4587-4596. Date of Electronic Publication: 2021 Nov 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Anti-Infective Agents*/chemistry , Anti-Infective Agents*/pharmacology , Lamiaceae* , Plectranthus*/chemistry , Triterpenes*/pharmacology, Anti-Bacterial Agents/chemistry ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Microbial Sensitivity Tests ; Plant Extracts/chemistry ; Plant Extracts/pharmacology |
| مستخلص: | Chemical investigation of the ethanol extract from the whole plant of Plectranthus glandulosus led to the isolation of a new nor-triterpenoid ( 1 ) along with seventeen known compounds ( 2-18 ) including seven triterpenoids, nine flavonoids and one steroid. Their structures were established on the basis of 1D- and 2D-NMR, IR, and MS experiments, and by comparison of their spectroscopic data with those of similar compounds reported in the literature. The EtOH extract and some isolated triterpenoids ( 1 - 4 and 13) were subjected to in vitro antimicrobial assays against a panel of pathogenic microorganisms, including Gram-positive and Gram-negative bacteria, and fungi using broth microdilution method. The EtOH extract displayed moderate activity (MIC = 512 µg/mL) against Staphylococcus aureus MSSA1, Shigella flexneri SDINT and Cryptococcus neoformans H99. Compounds 1 , 4 and 13 showed the most potent antimicrobial effect with MICs of 32-256 µg/mL. |
| فهرسة مساهمة: | Keywords: Lamiaceae; Plectranthus glandulosus; antimicrobial activity; nor-friedelane; triterpenoids |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Anti-Infective Agents) 0 (Plant Extracts) 0 (Triterpenes) 0 (friedelane) |
| تواريخ الأحداث: | Date Created: 20211103 Date Completed: 20220913 Latest Revision: 20220913 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14786419.2021.1999946 |
| PMID: | 34727811 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1478-6427 |
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| DOI: | 10.1080/14786419.2021.1999946 |