دورية أكاديمية
أعرض في EDS

Seizure control status and associated factors among pediatric epileptic patients at a neurologic outpatient clinic in Ethiopia.

التفاصيل البيبلوغرافية
العنوان: Seizure control status and associated factors among pediatric epileptic patients at a neurologic outpatient clinic in Ethiopia.
المؤلفون: Adal HD; Department of Pharmacy, Teda Health Sciences College, Gondar, Ethiopia., Alemu K; Department of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia., Muche EA; Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
المصدر: PloS one [PLoS One] 2021 Nov 03; Vol. 16 (11), pp. e0259079. Date of Electronic Publication: 2021 Nov 03 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Pediatrics*, Epilepsy/*therapy , Seizures/*therapy, Adolescent ; Ambulatory Care Facilities ; Child ; Child, Preschool ; Epilepsy/epidemiology ; Epilepsy/physiopathology ; Ethiopia/epidemiology ; Female ; Hospitals, Special ; Humans ; Infant ; Male ; Seizures/epidemiology ; Seizures/physiopathology
مستخلص: Background: Childhood epilepsy is a major public health problem worldwide. Even though anti-seizure medications (ASM) have been demonstrated to control seizures, children with epilepsy continue to have frequent seizures. There is a scarcity of data on seizure control status among pediatric epileptic patients in Ethiopia. The aim of this study was to assess seizure control status and associated factors among pediatric epileptic patients.
Methods: A hospital based cross-sectional study was done on 261 pediatric epileptic patients being followed up at the University of Gondar Comprehensive and Specialized Hospital, Northwest Ethiopia, from May 11 to August 11, 2019. The data were collected through caregiver interviews and patients' medical records. All independent variables with p value of ≤ 0.2 in univariate analysis were taken to multivariable analysis. Adjusted odds ratio (AOR) with a 95% confidence interval was computed to see the predictors of seizure control status. Level of statistical significance was declared if p-value < 0.05.
Result: From a total of 261 patients, 159 (60.9%) were males and had a mean age was 10.16 ± 4.62 years. More than half (57.1%) of participants were urban dwellers. Almost all (98.5%) were diagnosed with generalized tonic-clonic seizures. Majority (75.1%) of the patients were on mono-therapy. Forty-six (17.6%) of the patients reported adverse effects related to ASMs. Two hundred-three (77.8%) of the patients were adherent to their medications. Nearly half (49.0%) of the patients had controlled seizures. Urban residency (AOR: 2.12; 95% CI: 1.15-3.89; P = 0.016), adherence to medication (AOR: 3.92; 95% CI: 1.84-8.36; P < 0.001), use of combined ASM(AOR: 0.29; 95% CI: 0.14-0.59; P = 0. 001), durations of ASM use [2-5 years (AOR: 5.81; 95% CI: 2.89-11.70; P <0.001) and >5years (AOR: 4.80; 95% CI: 1.91-12.09; P = 0.001)]were significantly associated with seizure control status.
Conclusion: Inadequate numbers of pediatric epileptic patients' at the Ethiopian neurologic clinic achieved seizure control. Coming from a rural area, non-adherence to ASMs, use of multiple ASMs, and the use of ASMs for <2years were found to have a significant association with poorer seizure control, needing special attention to get control of seizure. Caregivers should closely monitor and address any barriers that contribute to ASM non-adherence and adverse drug events.
Competing Interests: The authors have declared that no competing interests exist.
References: PLoS One. 2020 Mar 12;15(3):e0230187. (PMID: 32163504)
J Clin Med. 2019 Jan 02;8(1):. (PMID: 30609770)
N Engl J Med. 2003 Apr 10;348(15):1442-8. (PMID: 12686700)
Epilepsia. 2005;46 Suppl 11:28-32. (PMID: 16393175)
Lancet Neurol. 2005 Jan;4(1):21-31. (PMID: 15620854)
Sci Rep. 2018 Nov 26;8(1):17354. (PMID: 30478263)
Semin Pediatr Neurol. 2014 Mar;21(1):36-41. (PMID: 24655403)
Pediatrics. 2018 Jun;141(6):. (PMID: 29789444)
Soc Sci Med. 1991;32(2):203-9. (PMID: 2014416)
Epilepsia. 2014 Apr;55(4):475-82. (PMID: 24730690)
Singapore Med J. 2010 Jan;51(1):21-7. (PMID: 20200771)
Seizure. 2012 Nov;21(9):734-9. (PMID: 22938819)
Neurology. 2012 May 15;78(20):1548-54. (PMID: 22573629)
Continuum (Minneap Minn). 2019 Apr;25(2):381-407. (PMID: 30921015)
Pediatrics. 2020 Jul;146(1):. (PMID: 32554521)
Epileptic Disord. 2007 Dec;9(4):353-412. (PMID: 18077226)
Epilepsy Behav. 2018 Jul;84:88-92. (PMID: 29754110)
BMC Pediatr. 2020 Jun 3;20(1):270. (PMID: 32493250)
Seizure. 2002 Jan;11(1):40-3. (PMID: 11888258)
Arq Neuropsiquiatr. 2011 Oct;69(5):766-9. (PMID: 22042178)
Ann Med Health Sci Res. 2014 Mar;4(2):186-91. (PMID: 24761235)
تواريخ الأحداث: Date Created: 20211103 Date Completed: 20211222 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC8565750
DOI: 10.1371/journal.pone.0259079
PMID: 34731195
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0259079