دورية أكاديمية
أعرض في EDS

Serial Intralesional Steroid Injection for Subglottic Stenosis: Systemic Side Effects and Impact on Surgery-Free Interval.

التفاصيل البيبلوغرافية
العنوان: Serial Intralesional Steroid Injection for Subglottic Stenosis: Systemic Side Effects and Impact on Surgery-Free Interval.
المؤلفون: Neevel AJ; Medical School, University of Michigan, Ann Arbor, Michigan, USA., Schuman AD; Medical School, University of Michigan, Ann Arbor, Michigan, USA., Morrison RJ; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA., Hogikyan ND; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.; Center for Bioethics and Social Sciences in Medicine, Medical School, University of Michigan, Ann Arbor, Michigan, USA., Kupfer RA; Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA.
المصدر: OTO open [OTO Open] 2021 Oct 29; Vol. 5 (4), pp. 2473974X211054842. Date of Electronic Publication: 2021 Oct 29 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley Periodicals LLC on behalf of American Academy of Otolaryngology–Head and Neck Surgery Foundation Country of Publication: United States NLM ID: 101717942 Publication Model: eCollection Cited Medium: Internet ISSN: 2473-974X (Electronic) Linking ISSN: 2473974X NLM ISO Abbreviation: OTO Open Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2023- : [Hoboken, NJ] : Wiley Periodicals LLC on behalf of American Academy of Otolaryngology–Head and Neck Surgery Foundation
Original Publication: [Thousand Oaks, CA] : Sage Publications, [2017]-
مستخلص: Objectives: In-office serial intralesional steroid injections (SILSIs) have become a commonly used treatment for subglottic stenosis. We characterized the impact of SILSIs on the time between operating room visits and incidence of glucocorticoid systemic side effects.
Study Design: Retrospective case series.
Setting: Academic tertiary care center.
Methods: All patients with subglottic stenosis receiving SILSIs at 1 institution from 2016 to 2020 were included. Surgery-free interval was compared using paired t tests. Side effect incidence was calculated with Kaplan-Meier methodology for visualization.
Results: Nineteen patients and 207 procedures were included. The majority of patients were White (95%) and female (95%) and had idiopathic subglottic stenosis (53%). Mean surgery-free interval for all patients was 8.7 months (95% CI, 5.6-11.8) before initiating SILSIs. Of 11 patients with calculable surgery-free interval, 10 experienced improvement, with a mean surgery-free interval increase of 4.6 months (95% CI, 2.4-6.7). Seven patients have not required surgery since initiation of SILSIs, with a mean follow-up time of 28 months (95% CI, 25-31). Noncutaneous systemic side effects occurred at a mean 3.2 months (95% CI, 2.4-4.0) from first injection and included Cushing's syndrome, increased intraocular pressure, central serous chorioretinopathy, and new insulin requirement in the setting of diabetes.
Conclusions: Ninety-one percent of patients who initiated SILSIs and had a subsequent return to the operating room experienced a mean 4.6-month increase in surgery-free interval. Systemic side effects of glucocorticoids occurred in 32% of patients after initiating SILSIs. This should be considered in preprocedure counseling and side effect monitoring during treatment.
(© The Authors 2021.)
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معلومات مُعتمدة: R01 DK084725 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Cushing’s syndrome; serial intralesional steroid injections; side effects; subglottic stenosis; surgery-free interval
تواريخ الأحداث: Date Created: 20211104 Latest Revision: 20220428
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8558814
DOI: 10.1177/2473974X211054842
PMID: 34734156
قاعدة البيانات: MEDLINE
الوصف
تدمد:2473-974X
DOI:10.1177/2473974X211054842