دورية أكاديمية
أعرض في EDS

Integration and functional performance of a decellularised porcine superflexor tendon graft in an ovine model of anterior cruciate ligament reconstruction.

التفاصيل البيبلوغرافية
العنوان: Integration and functional performance of a decellularised porcine superflexor tendon graft in an ovine model of anterior cruciate ligament reconstruction.
المؤلفون: Edwards JH; Institute of Medical and Biological Engineering, School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK; Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: J.H.Edwards@leeds.ac.uk., Jones GL; Institute of Medical and Biological Engineering, School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: g.l.jones@leeds.ac.uk., Herbert A; Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: a.herbert@leeds.ac.uk., Fisher J; Institute of Medical and Biological Engineering, School of Mechanical Engineering, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: j.fisher@leeds.ac.uk., Ingham E; Institute of Medical and Biological Engineering, School of Biomedical Sciences, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: e.ingham@leeds.ac.uk.
المصدر: Biomaterials [Biomaterials] 2021 Dec; Vol. 279, pp. 121204. Date of Electronic Publication: 2021 Oct 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 8100316 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5905 (Electronic) Linking ISSN: 01429612 NLM ISO Abbreviation: Biomaterials Subsets: MEDLINE
أسماء مطبوعة: Publication: <1995-> : Amsterdam : Elsevier Science
Original Publication: [Guilford, England] : IPC Science and Technology Press, 1980-
مواضيع طبية MeSH: Anterior Cruciate Ligament Injuries* , Anterior Cruciate Ligament Reconstruction*, Animals ; Anterior Cruciate Ligament/surgery ; Biomechanical Phenomena ; Physical Functional Performance ; Sheep ; Swine ; Tendons ; Transplantation, Homologous
مستخلص: The objective was to evaluate the performance of decellularised porcine superflexor tendon (pSFT) as an anterior cruciate ligament (ACL) reconstruction device. The ACL of adult sheep was reconstructed with decellularised pSFT or ovine allograft SFT and animals sacrificed at 4, 12 and 26 weeks (n = 4 per group) for biological evaluation and 26 weeks (n = 6) for biomechanical evaluation of the grafts. Both grafts showed good in vivo performance with no major differences at macroscopic evaluation post euthanasia. Histopathology revealed an inflammatory reaction to both grafts at 4 weeks, which reduced by 26 weeks. There was advanced cellular ingrowth from 12 weeks, ligamentisation of intra-articular grafts, ossification and formation of Sharpey's fibers at the graft/bone junctions. Immunohistochemistry showed that at 4 and 12 weeks, the host response was dominated by CD163+ M2 macrophages and a cell infiltrate comprising α-SMA + myofibroblasts, CD34 + and CD271+ progenitor cells. At 26 weeks the biomechanical properties of decellularised pSFT and oSFT grafts were comparable, with all grafts failing in the intra-articular region. This study provides new insight into constructive remodelling of tendons used for ACL replacement and evidence of integration and functional performance of a decellularised xenogeneic tendon with potential as an alternative for ACL reconstruction.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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فهرسة مساهمة: Keywords: Anterior cruciate ligament reconstruction; Cell infiltration; Decellularised tendon; Immune response; In vivo biocompatibility; Tissue biomechanics
تواريخ الأحداث: Date Created: 20211104 Date Completed: 20211214 Latest Revision: 20211231
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8683753
DOI: 10.1016/j.biomaterials.2021.121204
PMID: 34736146
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-5905
DOI:10.1016/j.biomaterials.2021.121204