دورية أكاديمية
Diagnostic scope of 18 F-PSMA-1007 PET/CT: comparison with multiparametric MRI and bone scintigraphy for the assessment of early prostate cancer recurrence.
| العنوان: | Diagnostic scope of 18 F-PSMA-1007 PET/CT: comparison with multiparametric MRI and bone scintigraphy for the assessment of early prostate cancer recurrence. |
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| المؤلفون: | Saule L; Riga Stradins University, Radiology Research Laboratory Riga, Latvia., Radzina M; Riga Stradins University, Radiology Research Laboratory Riga, Latvia.; University of Latvia Riga, Latvia.; Pauls Stradins Clinical University Hospital Riga, Latvia., Liepa M; Riga Stradins University, Radiology Research Laboratory Riga, Latvia.; Pauls Stradins Clinical University Hospital Riga, Latvia., Roznere L; Riga Stradins University, Radiology Research Laboratory Riga, Latvia.; Riga Stradins University Nuclear Medicine Clinic Riga, Latvia., Kalnina M; Pauls Stradins Clinical University Hospital Riga, Latvia.; Riga Stradins University Nuclear Medicine Clinic Riga, Latvia., Lioznovs A; Riga Stradins University, Radiology Research Laboratory Riga, Latvia., Mamis E; Riga Stradins University Nuclear Medicine Clinic Riga, Latvia., Mikelsone M; Riga Stradins University, Statistics Unit Riga, Latvia., Biederer J; University of Latvia Riga, Latvia.; Department of Diagnostic and Interventional Radiology, University Hospital of Heidelberg Heidelberg, Germany.; Translational Lung Research Center Heidelberg (TLRC), German Lung Research Center (DZL) Heidelberg, Germany.; Christian-Albrechts-Universität zu Kiel, Faculty of Medicine Kiel, Germany., Vjaters E; University of Latvia Riga, Latvia.; Pauls Stradins Clinical University Hospital Riga, Latvia.; Institute of Oncology, Riga Stradins University Riga, Latvia. |
| المصدر: | American journal of nuclear medicine and molecular imaging [Am J Nucl Med Mol Imaging] 2021 Oct 15; Vol. 11 (5), pp. 395-405. Date of Electronic Publication: 2021 Oct 15 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: e-Century Pub. Corp Country of Publication: United States NLM ID: 101564121 Publication Model: eCollection Cited Medium: Print ISSN: 2160-8407 (Print) NLM ISO Abbreviation: Am J Nucl Med Mol Imaging Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Madison, Wis. : e-Century Pub. Corp. |
| مستخلص: | The aim of this study was to compare the diagnostic tools- 18 F-PSMA-1007 positron emission tomography (PET/CT), magnetic resonance imaging (MRI) and bone scintigraphy for the evaluation of local recurrence, regional lymph nodes and bone metastases of recurrent prostate cancer (PCa). 28 PCa patients after radical prostatectomy and/or radiation therapy and with biochemical relapse were enrolled in this study. The evaluation of local recurrence and regional lymph node metastases was based on results of PET/CT and MRI. Local recurrent disease in 28 patients was detected by PET/CT in 36% (10/28) and by MRI in 32% (9/28) with sensitivity, specificity, accuracy of 90.9%, 100%, 96.4% and 81.8%, 100%, 92.9%, respectively (kappa 0.92, P<0.001). Nodal involvement was confirmed by PET/CT and MRI in 46% (13/28) and 25% (7/28) with sensitivity, specificity and accuracy for PET/CT 92.3%, 93.3%, 92.9% and for MRI-53.8%, 100%, 78.6%, respectively (kappa 0.57, P<0.001). The evaluation of skeletal metastases was based on PET/CT and bone scintigraphy. Bone metastases were seen on PET/CT and bone scintigraphy in 21% (6/28) and 20% (5/25) with sensitivity, specificity and accuracy of 100%; 91.7%; 92.9% and 50.0%; 85.7%; 80.0%, respectively (kappa 0.41, P<0.01). In conclusion, our comparative study demonstrates advantages of 18 F-PSMA-1007 PET/CT compared to MRI and scintigraphy for the evaluation of recurrent prostate cancer. Both methods, 18 F-PSMA-1007 PET/CT and MRI, detect local recurrence with high accuracy and excellent agreement, which may be attributed to the low urinary background clearance of 18 F-PSMA-1007. Competing Interests: None. (AJNMMI Copyright © 2021.) |
| References: | Top Magn Reson Imaging. 2016 Jun;25(3):139-47. (PMID: 27187164) J Nucl Med. 2018 Apr;59(4):632-635. (PMID: 29419475) Eur Urol. 2015 Feb;67(2):299-309. (PMID: 24571959) J Nucl Med. 2018 Mar;59(3):469-478. (PMID: 29123012) Adv Radiat Oncol. 2020 Aug 31;5(6):1126-1140. (PMID: 33305073) Eur J Nucl Med Mol Imaging. 2018 Nov;45(12):2055-2061. (PMID: 30027419) Insights Imaging. 2015 Dec;6(6):611-30. (PMID: 26385690) J Nucl Med. 2020 Apr;61(4):527-532. (PMID: 31562225) Radiol Clin North Am. 2017 Mar;55(2):303-320. (PMID: 28126217) Mol Imaging Biol. 2016 Jun;18(3):411-9. (PMID: 27080322) World J Urol. 2019 Dec;37(12):2573-2583. (PMID: 30069582) Eur J Nucl Med Mol Imaging. 2016 Jan;43(1):70-83. (PMID: 26508290) Eur Urol. 2014 Feb;65(2):467-79. (PMID: 24321502) |
| فهرسة مساهمة: | Keywords: 18F-PSMA-1007 PET/CT; MRI; prostate cancer; recurrence; scintigraphy |
| تواريخ الأحداث: | Date Created: 20211110 Latest Revision: 20211111 |
| رمز التحديث: | 20240829 |
| مُعرف محوري في PubMed: | PMC8569331 |
| PMID: | 34754610 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2160-8407 |
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