دورية أكاديمية
Loss of skeletal muscle density during neoadjuvant chemotherapy in older women with advanced stage ovarian cancer is associated with postoperative complications.
| العنوان: | Loss of skeletal muscle density during neoadjuvant chemotherapy in older women with advanced stage ovarian cancer is associated with postoperative complications. |
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| المؤلفون: | van der Zanden V; University Medical Center Groningen, University of Groningen, Department of Internal Medicine, Hanzeplein 1, 9713GZ Groningen, the Netherlands. Electronic address: v.van.der.zanden@umcg.nl., van Soolingen NJ; The Netherlands Cancer Institute, Department of Gynecologic Oncology, Center for Gynecologic Oncology Amsterdam, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands., Viddeleer AR; University Medical Center Groningen, University of Groningen, Department of Radiology, Medical Imaging Center, Hanzeplein 1, 9713GZ Groningen, the Netherlands., Trum JW; The Netherlands Cancer Institute, Department of Gynecologic Oncology, Center for Gynecologic Oncology Amsterdam, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands., Amant F; The Netherlands Cancer Institute, Department of Gynecologic Oncology, Center for Gynecologic Oncology Amsterdam, Plesmanlaan 121, 1066CX Amsterdam, the Netherlands; KU Leuven, Department of Oncology, Herestraat 49, 3000 Leuven, Belgium., Mourits MJE; University Medical Center Groningen, University of Groningen, Department of Gynecological Oncology, Hanzeplein 1, 9713GZ Groningen, the Netherlands., Portielje JEA; Leiden University Medical Center, Leiden University, Department of Medical Oncology, Albinusdreef 2, 2333ZA Leiden, the Netherlands., Baalbergen A; Reinier de Graaf Group, Department of Obstetrics and Gynecology, Reinier de Graafweg 5, 2625AD Delft, the Netherlands., Souwer ETD; Leiden University Medical Center, Leiden University, Department of Medical Oncology, Albinusdreef 2, 2333ZA Leiden, the Netherlands., van Munster BC; University Medical Center Groningen, University of Groningen, Department of Internal Medicine, Hanzeplein 1, 9713GZ Groningen, the Netherlands. Electronic address: b.c.van.munster@umcg.nl. |
| المصدر: | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2022 Apr; Vol. 48 (4), pp. 896-902. Date of Electronic Publication: 2021 Oct 22. |
| نوع المنشور: | Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 8504356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2157 (Electronic) Linking ISSN: 07487983 NLM ISO Abbreviation: Eur J Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: London ; New York : Academic Press, [1985- |
| مواضيع طبية MeSH: | Neoadjuvant Therapy*/methods , Ovarian Neoplasms*/complications , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/surgery, Aged ; Aged, 80 and over ; Carcinoma, Ovarian Epithelial/surgery ; Chemotherapy, Adjuvant/methods ; Cytoreduction Surgical Procedures/methods ; Female ; Humans ; Muscle, Skeletal/diagnostic imaging ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Retrospective Studies |
| مستخلص: | Objective: To assess the association between loss of lumbar skeletal muscle mass and density during neoadjuvant chemotherapy (NACT) and postoperative complications after interval cytoreductive surgery (CRS) in older patients with ovarian cancer. Materials and Methods: This multicenter, retrospective cohort study included patients aged 70 years and older with primary advanced stage ovarian cancer (International Federation of Gynecology and Obstetrics stage III-IV), treated with NACT and interval CRS. Skeletal muscle mass and density were retrospectively assessed using Skeletal Muscle Index (SMI) and Muscle Attenuation (MA) on routinely made Computed Tomography scans before and after NACT. Loss of skeletal muscle mass or density was defined as >2% decrease per 100 days in SMI or MA during NACT. Results: In total, 111 patients were included. Loss of skeletal muscle density during NACT was associated with developing any postoperative complication ≤30 days after interval CRS both in univariable (Odds Ratio (OR) 3.69; 95% Confidence Interval (CI) 1.57-8.68) and in multivariable analysis adjusted for functional impairment and WHO performance status (OR 3.62; 95%CI 1.27-10.25). Loss of skeletal muscle density was also associated with infectious complications (OR 3.67; 95%CI 1.42-9.52) and unintended discontinuation of adjuvant chemotherapy (OR 5.07; 95%CI 1.41-18.19). Unlike loss of skeletal muscle density, loss of skeletal muscle mass showed no association with postoperative outcomes. Conclusion: In older patients with ovarian cancer, loss of skeletal muscle density during NACT is associated with worse postoperative outcomes. These results could add to perioperative risk assessment, guiding the decision to undergo surgery or the need for perioperative interventions. Competing Interests: Declaration of competing interest None. (Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Complications; Computed tomography; Elderly; Interval cytoreductive surgery; Ovarian cancer; Sarcopenia |
| تواريخ الأحداث: | Date Created: 20211110 Date Completed: 20220412 Latest Revision: 20220509 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.ejso.2021.10.015 |
| PMID: | 34756760 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-2157 |
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| DOI: | 10.1016/j.ejso.2021.10.015 |