دورية أكاديمية
أعرض في EDS

Klf5 establishes bi-potential cell fate by dual regulation of ICM and TE specification genes.

التفاصيل البيبلوغرافية
العنوان: Klf5 establishes bi-potential cell fate by dual regulation of ICM and TE specification genes.
المؤلفون: Kinisu M; Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94705, USA., Choi YJ; Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94705, USA., Cattoglio C; Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94705, USA; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA., Liu K; Department of Statistics, University of California, Berkeley, Berkeley, CA 94720, USA., Roux de Bezieux H; Division of Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA., Valbuena R; Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94705, USA., Pum N; Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94705, USA., Dudoit S; Division of Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA 94720, USA., Huang H; Department of Statistics, University of California, Berkeley, Berkeley, CA 94720, USA., Xuan Z; Department of Molecular and Cell Biology, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080, USA., Kim SY; Department of Pathology, NYU Grossman School of Medicine, 540 First Avenue, New York, NY 10016, USA., He L; Division of Cellular and Developmental Biology, MCB Department, University of California, Berkeley, Berkeley, CA 94705, USA. Electronic address: lhe@berkeley.edu.
المصدر: Cell reports [Cell Rep] 2021 Nov 09; Vol. 37 (6), pp. 109982.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Blastocyst* , Cell Lineage* , Gene Expression Regulation, Developmental*, Blastocyst Inner Cell Mass/*cytology , Embryonic Stem Cells/*cytology , Kruppel-Like Transcription Factors/*metabolism , Trophoblasts/*cytology, Animals ; Blastocyst Inner Cell Mass/metabolism ; Cell Differentiation ; Embryonic Stem Cells/metabolism ; Female ; Kruppel-Like Transcription Factors/genetics ; Male ; Mice ; Mice, Inbred C3H ; Mice, Inbred C57BL ; RNA-Seq ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Trophoblasts/metabolism
مستخلص: Early blastomeres of mouse preimplantation embryos exhibit bi-potential cell fate, capable of generating both embryonic and extra-embryonic lineages in blastocysts. Here we identify three major two-cell-stage (2C)-specific endogenous retroviruses (ERVs) as the molecular hallmark of this bi-potential plasticity. Using the long terminal repeats (LTRs) of all three 2C-specific ERVs, we identify Krüppel-like factor 5 (Klf5) as their major upstream regulator. Klf5 is essential for bi-potential cell fate; a single Klf5-overexpressing embryonic stem cell (ESC) generates terminally differentiated embryonic and extra-embryonic lineages in chimeric embryos, and Klf5 directly induces inner cell mass (ICM) and trophectoderm (TE) specification genes. Intriguingly, Klf5 and Klf4 act redundantly during ICM specification, whereas Klf5 deficiency alone impairs TE specification. Klf5 is regulated by multiple 2C-specific transcription factors, particularly Dux, and the Dux/Klf5 axis is evolutionarily conserved. The 2C-specific transcription program converges on Klf5 to establish bi-potential cell fate, enabling a cell state with dual activation of ICM and TE genes.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
References: Front Cell Dev Biol. 2020 Jan 17;7:385. (PMID: 32010697)
Front Oncol. 2014 Feb 06;4:14. (PMID: 24567914)
Genome Biol. 2008;9(9):R137. (PMID: 18798982)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
Nat Genet. 2017 Jun;49(6):925-934. (PMID: 28459457)
Sci Rep. 2017 Nov 9;7(1):15136. (PMID: 29123210)
Nat Genet. 2019 Jun;51(6):947-951. (PMID: 31133747)
Science. 2014 Jan 10;343(6167):193-6. (PMID: 24408435)
Nat Protoc. 2018 Jun;13(6):1253-1274. (PMID: 29748649)
BMC Genomics. 2018 Jun 19;19(1):477. (PMID: 29914354)
Development. 2003 Nov;130(21):5113-22. (PMID: 12944430)
Dev Cell. 2017 Feb 6;40(3):235-247.e7. (PMID: 28171747)
Bioinformatics. 2014 Apr 1;30(7):923-30. (PMID: 24227677)
Genome Biol. 2021 Jun 29;22(1):193. (PMID: 34187518)
Development. 1989 Apr;105(4):733-7. (PMID: 2598811)
Nucleic Acids Res. 2016 Jan 4;44(D1):D81-9. (PMID: 26612867)
Sci Rep. 2013 Dec 13;3:3492. (PMID: 24336466)
Nat Protoc. 2006;1(4):2082-7. (PMID: 17487198)
Science. 2017 Feb 10;355(6325):. (PMID: 28082412)
Nat Cell Biol. 2020 Feb;22(2):175-186. (PMID: 31932739)
Development. 2010 Dec;137(23):3953-63. (PMID: 20980403)
Cell. 2005 Dec 2;123(5):917-29. (PMID: 16325584)
J Mol Med (Berl). 2017 Jul;95(7):687-694. (PMID: 28102431)
Nature. 2012 Jul 5;487(7405):57-63. (PMID: 22722858)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Nat Biotechnol. 2016 May;34(5):525-7. (PMID: 27043002)
Sci Rep. 2017 Aug 15;7(1):8299. (PMID: 28811525)
Mol Cell Biol. 2011 Nov;31(21):4366-78. (PMID: 21896782)
Cell Stem Cell. 2008 Nov 6;3(5):555-67. (PMID: 18983969)
Development. 2017 Oct 15;144(20):3706-3718. (PMID: 28870993)
Nat Cell Biol. 2011 Oct 23;13(11):1353-60. (PMID: 22020437)
Nucleic Acids Res. 2015 Apr 20;43(7):e47. (PMID: 25605792)
Development. 2018 May 30;145(10):. (PMID: 29739838)
Nat Genet. 2017 Jun;49(6):941-945. (PMID: 28459456)
Genome Biol. 2004;5(3):R14. (PMID: 15003117)
Genes Dev. 2011 Mar 15;25(6):594-607. (PMID: 21357675)
Nucleic Acids Res. 2016 Jan 4;44(D1):D110-5. (PMID: 26531826)
Biology (Basel). 2018 Jul 23;7(3):. (PMID: 30041494)
Genes Dev. 2019 Feb 1;33(3-4):194-208. (PMID: 30692203)
PLoS Biol. 2019 Jun 21;17(6):e3000324. (PMID: 31226106)
Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14097-102. (PMID: 14617767)
Genome Biol. 2010;11(10):R106. (PMID: 20979621)
Genome Biol Evol. 2015 Jul 30;7(8):2289-309. (PMID: 26232396)
Cell Syst. 2020 Jul 22;11(1):25-41.e9. (PMID: 32634384)
Genome Res. 2017 Aug;27(8):1384-1394. (PMID: 28522611)
Nature. 2017 Oct 19;550(7676):393-397. (PMID: 29019987)
Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9. (PMID: 24194600)
Genome Res. 2012 Sep;22(9):1760-74. (PMID: 22955987)
Nat Commun. 2020 Mar 5;11(1):1201. (PMID: 32139671)
Nat Struct Mol Biol. 2015 Sep;22(9):662-71. (PMID: 26237512)
Cell. 2017 Apr 6;169(2):243-257.e25. (PMID: 28388409)
Nucleic Acids Res. 2017 Dec 1;45(21):12301-12310. (PMID: 29036642)
Development. 2002 Jun;129(11):2619-28. (PMID: 12015290)
Curr Biol. 2013 Jul 8;23(13):1181-94. (PMID: 23791731)
Development. 2005 May;132(9):2093-102. (PMID: 15788452)
Cell Stem Cell. 2018 Jul 05;23(1):31-45.e7. (PMID: 29937202)
Nat Struct Mol Biol. 2014 Apr;21(4):423-5. (PMID: 24681886)
Nucleic Acids Res. 2017 Jan 4;45(D1):D658-D662. (PMID: 27789702)
Curr Biol. 2013 Jan 7;23(1):21-31. (PMID: 23177476)
معلومات مُعتمدة: R21 OD027053 United States OD NIH HHS; R21 NS099761 United States NS NINDS NIH HHS; R21 HD088885 United States HD NICHD NIH HHS; R21 CA175560 United States CA NCI NIH HHS; S10 OD018174 United States OD NIH HHS; United States HHMI Howard Hughes Medical Institute
فهرسة مساهمة: Keywords: ICM; Klf4; Klf5; MERVL; ORR1A0; ORR1A1; TE; preimplantation development
المشرفين على المادة: 0 (Klf5 protein, mouse)
0 (Kruppel-Like Transcription Factors)
0 (Transcription Factors)
تواريخ الأحداث: Date Created: 20211110 Date Completed: 20220217 Latest Revision: 20220217
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8711565
DOI: 10.1016/j.celrep.2021.109982
PMID: 34758315
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2021.109982