دورية أكاديمية
أعرض في EDS

Resection Status Does Not Impact Recurrence in Well-Differentiated Liposarcoma of the Extremity.

التفاصيل البيبلوغرافية
العنوان: Resection Status Does Not Impact Recurrence in Well-Differentiated Liposarcoma of the Extremity.
المؤلفون: Olson CR; Department of Surgery, 21822University of South Alabama, Mobile, AL, USA., Suarez-Kelly LP; Department of Surgery, 10624Stanford University, Palo Alto, CA, USA., Ethun CG; Department of Surgery, 12246University of Chicago Medicine, Chicago, IL, USA., Shelby RD; Department of Surgery, 10624Stanford University, Palo Alto, CA, USA., Yu PY; Department of Surgery, 10624Stanford University, Palo Alto, CA, USA., Hughes TM; Department of Surgery, 10624Stanford University, Palo Alto, CA, USA., Palettas M; Department of Surgery, 10624Stanford University, Palo Alto, CA, USA., Tran TB; Department of Surgery, 12280Wake Forest University, Winston-Salem, NC, USA., Poultsides G; Department of Surgery, 12280Wake Forest University, Winston-Salem, NC, USA., Tseng J; Department of Surgery, 12275Washington University School of Medicine, St. Louis, MO, USA., Roggin KK; Department of Surgery, 12275Washington University School of Medicine, St. Louis, MO, USA., Chouliaras K; Department of Surgery, 5506Medical College of Wisconsin, Milwaukee, WI, USA., Votanopoulos K; Department of Surgery, 5506Medical College of Wisconsin, Milwaukee, WI, USA., Krasnick BA; Department of Surgery, 12306The Ohio State University, Columbus, OH, USA., Fields RC; Department of Surgery, 12306The Ohio State University, Columbus, OH, USA., King DM; Department of Surgery, 23034Emory University, Atlanta, GA, USA., Bedi M; Department of Surgery, 23034Emory University, Atlanta, GA, USA., Pollock RE; Department of Surgery, 12306The Ohio State University, Columbus, OH, USA., Grignol VP; Department of Surgery, 10624Stanford University, Palo Alto, CA, USA., Cardona K; Department of Surgery, 12246University of Chicago Medicine, Chicago, IL, USA., Howard JH; Department of Surgery, 21822University of South Alabama, Mobile, AL, USA.; Department of Surgery, 10624Stanford University, Palo Alto, CA, USA.
المصدر: The American surgeon [Am Surg] 2021 Nov; Vol. 87 (11), pp. 1752-1759. Date of Electronic Publication: 2021 Nov 10.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: SAGE Publications in association with Southeastern Surgical Congress Country of Publication: United States NLM ID: 0370522 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1555-9823 (Electronic) Linking ISSN: 00031348 NLM ISO Abbreviation: Am Surg Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : [Thousand Oaks, CA] : SAGE Publications in association with Southeastern Surgical Congress
Original Publication: Atlanta Ga : Southeastern Surgical Congress
مواضيع طبية MeSH: Arm*/surgery , Leg*/surgery, Liposarcoma/*surgery , Neoplasm Recurrence, Local/*epidemiology , Soft Tissue Neoplasms/*surgery, Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Female ; Humans ; Liposarcoma/mortality ; Male ; Margins of Excision ; Middle Aged ; Neoplasm Recurrence, Local/mortality ; Retrospective Studies ; Risk Factors ; Soft Tissue Neoplasms/mortality
مستخلص: Background: Well-differentiated liposarcoma (WDLPS) is a low-grade soft tissue sarcoma with a propensity for local recurrence. The necessity of obtaining microscopically free surgical margins (R0) to minimize local recurrence is not clear. This study evaluates recurrence-free survival (RFS) of extremity WDLPS in relation to resection margin status.
Methods: A retrospective review of adult patients with primary extremity WDLPS at seven US institutions from 2000 to 2016 was performed. Patients with recurrent tumors or incomplete resection (R2) were excluded. Clinicopathologic factors were analyzed to assess impact on local RFS.
Results: 97 patients with primary extremity WDLPS were identified. The majority of patients had deep, lower extremity tumors. Mean tumor size was 18.2±8.9cm. Patients were treated with either radical (76.3%) or excisional (23.7%) resections; 64% had R0 and 36% had microscopically positive (R1) resection margins. Ten patients received radiation therapy with no difference in receipt of radiation between R0 vs R1 groups. Thirteen patients (13%) developed a local recurrence with no difference in RFS between R0 vs R1 resection. Five-year RFS was 59.5% for R0 vs 85.2% for R1. Only one patient died of disease after developing dedifferentiation and distant metastasis despite originally having an R0 resection.
Discussion: In this large multi-institutional study of surgical resection of extremity WDLPS, microscopically positive margins were not associated with an increased risk of recurrence. Positive microscopic margin resection for extremity WDLPS may yield similar rates of local control while avoiding a radical approach to obtain microscopically negative margins.
تواريخ الأحداث: Date Created: 20211111 Date Completed: 20211213 Latest Revision: 20211214
رمز التحديث: 20221213
DOI: 10.1177/00031348211054536
PMID: 34758653
قاعدة البيانات: MEDLINE
الوصف
تدمد:1555-9823
DOI:10.1177/00031348211054536