دورية أكاديمية
Effect of heat stable carbetocin vs oxytocin for preventing postpartum haemorrhage on post delivery hemoglobin-a randomized controlled trial.
| العنوان: | Effect of heat stable carbetocin vs oxytocin for preventing postpartum haemorrhage on post delivery hemoglobin-a randomized controlled trial. |
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| المؤلفون: | Vernekar SS; Women's and Children's Health Research Unit, J N Medical College, KLE Academy of Higher Education and Research, Belagavi, India., Goudar SS; Obstetrics and Gynaecology, Amrita Institute of Medical Sciences, Kochi, India., Metgud M; Women's and Children's Health Research Unit, J N Medical College, KLE Academy of Higher Education and Research, Belagavi, India., Pujar YV; Women's and Children's Health Research Unit, J N Medical College, KLE Academy of Higher Education and Research, Belagavi, India., Somannavar MS; Women's and Children's Health Research Unit, J N Medical College, KLE Academy of Higher Education and Research, Belagavi, India., Piaggio G; Statistika Consultoria, Campinas, Brazil., Carvalho JFDE; Statistika Consultoria, Campinas, Brazil., Revankar A; Women's and Children's Health Research Unit, J N Medical College, KLE Academy of Higher Education and Research, Belagavi, India., Althabe F; Reproductive Health and Research, World Health Organization, Geneva, Switzerland., Widmer M; Maternal and Perinatal Health, World Health Organization, Geneva, Switzerland., Gulmezoglu AM; Concept Foundation, Geneva, Switzerland., Goudar SS; Women's and Children's Health Research Unit, J N Medical College, KLE Academy of Higher Education and Research, Belagavi, India. |
| المصدر: | The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians [J Matern Fetal Neonatal Med] 2022 Dec; Vol. 35 (25), pp. 8744-8751. Date of Electronic Publication: 2021 Nov 11. |
| نوع المنشور: | Randomized Controlled Trial; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136916 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4954 (Electronic) Linking ISSN: 14764954 NLM ISO Abbreviation: J Matern Fetal Neonatal Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Boca Raton : Parthenon Pub. Group, c2002- |
| مواضيع طبية MeSH: | Oxytocics*/therapeutic use , Postpartum Hemorrhage*/prevention & control, Female ; Humans ; Pregnancy ; Hemoglobin A ; Hemoglobins ; Oxytocin/analogs & derivatives |
| مستخلص: | Objective: To compare the effect of heat-stable carbetocin 100 μg IM versus oxytocin 10 IU IM on post-delivery hemoglobin level. Setting: Hospital based study in Southern India. Population: Women delivering vaginally who were enrolled in the WHO CHAMPION trial in a single facility in India. WHO CHAMPION Trial was a randomized, double-blind, noninferiority trial comparing intramuscular injections of heat-stable carbetocin with oxytocin administered immediately after vaginal birth in women across 23 sites in 10 countries. Methods: This was a nested randomized controlled trial designed to compare the effect of heat-stable carbetocin 100 μg IM versus oxytocin 10 IU IM, administered within one minute of vaginal delivery of the baby for prevention of postpartum hemorrhage, on post-delivery 48-72 h hemoglobin level, adjusted for pre-delivery hemoglobin level. 1,799 women from one hospital in India participated in this study. Results: Pre-delivery hemoglobin and postpartum blood loss were not significantly different between carbetocin and oxytocin. Post-delivery hemoglobin, unadjusted or adjusted for pre-delivery hemoglobin, was slightly lower for carbetocin (10.09 g/dL) compared to oxytocin (10.21) (p value of 0.0432). The drop in hemoglobin was slightly higher for carbetocin, although the difference was very small (1.2 g/dL for carbetocin, 1.1 g/dL for oxytocin) ( p value of .0786). The proportion of participants with a drop in hemoglobin of 2 g/dL or more, adjusted for pre-delivery hemoglobin, was higher for carbetocin (RR = 1.29, 95% CI 1.02-1.63). From the regression coefficients it can be derived that post-delivery hemoglobin, adjusted for pre-delivery hemoglobin, decreases on average 0.12 g/dL for each dL of blood lost, for the two treatments combined. Conclusion: The present ancillary study showed that intramuscular administration of 100 µg of heat stable carbetocin can result in a slightly lower post-delivery hemoglobin, slightly higher drop and higher percentage of women having a drop of 2 g/dL or larger, compared to 10 IU of oxytocin. |
| معلومات مُعتمدة: | 001 International WHO_ World Health Organization |
| فهرسة مساهمة: | Keywords: Post-partum hemorrhage; heat-stable carbetocin; oxytocin; post-delivery hemoglobin; uterotonics |
| المشرفين على المادة: | 88TWF8015Y (carbetocin) 9034-51-9 (Hemoglobin A) 0 (Hemoglobins) 0 (Oxytocics) 50-56-6 (Oxytocin) |
| تواريخ الأحداث: | Date Created: 20211112 Date Completed: 20221125 Latest Revision: 20221125 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14767058.2021.2001799 |
| PMID: | 34763599 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1476-4954 |
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| DOI: | 10.1080/14767058.2021.2001799 |