دورية أكاديمية
Different Age Related Neurological and Cardiac Effects of Verapamil on a Transgenic Mouse Model of Alzheimer's Disease.
| العنوان: | Different Age Related Neurological and Cardiac Effects of Verapamil on a Transgenic Mouse Model of Alzheimer's Disease. |
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| المؤلفون: | Cojocaru A; Department of Physiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.; Experimental Research Center for Normal and Pathological Aging,University of Medicine and Pharmacy of Craiova, Romania., Zavaleanu AD; Department of Physiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.; Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania., Călina DC; Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, Romania., Gheonea DI; Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania., Osiac E; Department of Physiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.; Department of Biophysics, University of Medicine and Pharmacy of Craiova, Romania., Boboc IKS; Experimental Research Center for Normal and Pathological Aging,University of Medicine and Pharmacy of Craiova, Romania.; Department of Gastroenterology, University of Medicine and Pharmacy of Craiova, Romania., Mitran SI; Department of Physiology, University of Medicine and Pharmacy of Craiova, Craiova, Romania. |
| المصدر: | Current health sciences journal [Curr Health Sci J] 2021 Apr-Jun; Vol. 47 (2), pp. 263-269. Date of Electronic Publication: 2021 Jun 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medical University Publishing House Country of Publication: Romania NLM ID: 101597164 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2067-0656 (Print) NLM ISO Abbreviation: Curr Health Sci J Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: <2013>- : Craiova : Medical University Publishing House Original Publication: Craiova : Editura Medicală Universitară |
| مستخلص: | Dementias are the third cause of the disability-adjusted life-years (DALYs) worldwide with Alzheimer's (AD) having the highest prevalence. Despite ample research in the field, therapeutic options are limited. However, with the increase in lifespan, a larger number of AD patients will receive other medication for the evermore-increased number of comorbidities that such patients face. The purpose of this study was to evaluate the neurological and cardiac effects of verapamil, on C57BL/6J-TgN (Thy1-APPKM670/671NL; Thy1-PS1L166P (APP) mice. The daily administration of 3.5mg/kg of verapamil for 28 days revealed different effects on young and aged APP mice. While young animals showed less anxiety and improved short-term memory with minimal cardiac effects (an increase in the duration of ventricular depolarization), aged ones did not present behavioral improvements, but with a decrease in the duration of ventricular depolarizing. Repolarization effects of verapamil were similar in young and aged animals, except for the duration of the ST segment that was longer in aged animals. Considering our results, the use of calcium blockers in AD patients should take into consideration the stage of the disease, as different effects could be seen at different stages of AD, in our model. Competing Interests: None to declare. (Copyright © 2014, Medical University Publishing House Craiova.) |
| References: | Toxicon. 2017 Apr;129:58-67. (PMID: 28202361) Eur J Pharmacol. 2011 Jun 1;659(2-3):124-9. (PMID: 21497592) Behav Neurol. 2019 Sep 8;2019:8720904. (PMID: 31583024) Hum Mol Genet. 2010 Apr 15;19(R1):R12-20. (PMID: 20413653) Glia. 2015 Apr;63(4):664-72. (PMID: 25472417) N Engl J Med. 2013 Jan 10;368(2):117-27. (PMID: 23150934) Curr Med Chem. 2008;15(23):2321-8. (PMID: 18855662) Br J Pharmacol. 1985 May;85(1):89-96. (PMID: 4027475) Acta Physiol (Oxf). 2013 Dec;209(4):262-71. (PMID: 24119104) J Mol Med (Berl). 2016 Jul;94(7):739-46. (PMID: 27277824) J Clin Invest. 2005 Jun;115(6):1449-57. (PMID: 15931380) Brain. 2018 Feb 1;141(2):596-612. (PMID: 29272333) Am J Physiol. 1983 Jan;244(1):H80-8. (PMID: 6849408) Front Aging Neurosci. 2021 Feb 12;13:631770. (PMID: 33643025) Physiol Rep. 2015 Dec;3(12):. (PMID: 26660552) Trends Mol Med. 2010 Jun;16(6):287-94. (PMID: 20537952) Brain. 2013 Apr;136(Pt 4):1067-82. (PMID: 23518709) Science. 1993 Aug 13;261(5123):921-3. (PMID: 8346443) Neuroscience. 1997 Jun;78(4):1217-28. (PMID: 9174088) Dis Model Mech. 2011 Sep;4(5):634-48. (PMID: 21596710) Life Sci. 2003 Apr 11;72(21):2401-12. (PMID: 12639705) J Alzheimers Dis. 2010;21(1):291-301. (PMID: 20421698) Front Pharmacol. 2017 Aug 23;8:566. (PMID: 28878678) Neurobiol Aging. 2005 Mar;26(3):355-61. (PMID: 15639314) Glia. 2014 Dec;62(12):2080-95. (PMID: 25043721) Int J Mol Sci. 2021 Feb 19;22(4):. (PMID: 33669857) Neurobiol Aging. 2011 Dec;32(12):2324.e1-6. (PMID: 20970889) Int J Environ Res Public Health. 2020 May 13;17(10):. (PMID: 32414124) Mol Neurobiol. 2021 Jul;58(7):3374-3387. (PMID: 33704677) Arch Gen Psychiatry. 2006 Feb;63(2):168-74. (PMID: 16461860) Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):. (PMID: 22908189) Lancet. 2015 Nov 28;386(10009):2145-91. (PMID: 26321261) EMBO Rep. 2006 Sep;7(9):940-6. (PMID: 16906128) |
| فهرسة مساهمة: | Keywords: Alzheimer’s; Calcium blockers; age |
| تواريخ الأحداث: | Date Created: 20211112 Latest Revision: 20211113 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8551894 |
| DOI: | 10.12865/CHSJ.47.02.17 |
| PMID: | 34765247 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2067-0656 |
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| DOI: | 10.12865/CHSJ.47.02.17 |