دورية أكاديمية
The Antibacterial Activity of 1,2,3-triazole- and 1,2,4-Triazole-containing Hybrids against Staphylococcus aureus : An Updated Review (2020- Present).
| العنوان: | The Antibacterial Activity of 1,2,3-triazole- and 1,2,4-Triazole-containing Hybrids against Staphylococcus aureus : An Updated Review (2020- Present). |
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| المؤلفون: | Li J; Department of Respiratory, Zhuji Central Hospital of Zhejiang Province, Shaoxing 311800, PR China., Zhang J; Department of Emergency, Zhuji Affiliated Hospital of Shaoxing University, Shaoxing 311800, PR China. |
| المصدر: | Current topics in medicinal chemistry [Curr Top Med Chem] 2022; Vol. 22 (1), pp. 41-63. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101119673 Publication Model: Print Cited Medium: Internet ISSN: 1873-4294 (Electronic) Linking ISSN: 15680266 NLM ISO Abbreviation: Curr Top Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers Original Publication: Hilversum, The Netherlands : Bentham Science Publishers, c2001- |
| مواضيع طبية MeSH: | Methicillin-Resistant Staphylococcus aureus* , Staphylococcus aureus*, Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Microbial Sensitivity Tests ; Structure-Activity Relationship ; Topoisomerase II Inhibitors/pharmacology ; Triazoles/chemistry ; Triazoles/pharmacology |
| مستخلص: | Staphylococcus aureus (S. aureus) , a prominent, highly contagious nosocomial and community- acquired bacterial pathogen, can cause a broad spectrum of diseases. Antibiotic-resistant S. aureus strains, which pose potential causes of morbidity and mortality, have continuously emerged in recent years, calling for novel anti- S. aureus agents. 1,2,3-triazole and 1,2,4-triazole, the bioisostere of amides, esters, and carboxylic acids, are potent inhibitors of DNA gyrase, topoisomerase IV, efflux pumps, filamentous temperature-sensitive protein Z, and penicillin-binding protein. In particular, 1,2,3-triazole- and 1,2,4-triazole-containing hybrids have the potential to exert dual or multiple antibacterial mechanisms of action. Moreover, 1,2,3-triazole-cephalosporin hybrid cefatrizine, 1,2,3- triazole-oxazolidinone hybrid radezolid, and 1,2,4-triazolo[1,5-a]pyrimidine hybrid essramycin, have already been used in clinical practice to treat bacterial infections. Hence, 1,2,3-triazole- and 1,2,4- triazole-containing hybrids possess promising broad-spectrum antibacterial activity against diverse clinically significant organisms, including drug-resistant forms. This review is an update on the latest development of 1,2,3-triazole- and 1,2,4-triazole-containing hybrids with anti-S. aureus activity, covering articles published between January 2020 and July 2021. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: 1,2,3-triazole; 1,4-triazole; Antibacterial; Hybrid compounds; Staphylococcus aureus; Synthesis |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Topoisomerase II Inhibitors) 0 (Triazoles) 288-88-0 (1,2,4-triazole) |
| تواريخ الأحداث: | Date Created: 20211112 Date Completed: 20220301 Latest Revision: 20220301 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/1568026621666211111160332 |
| PMID: | 34766892 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1873-4294 |
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| DOI: | 10.2174/1568026621666211111160332 |