دورية أكاديمية
أعرض في EDS

Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer.

التفاصيل البيبلوغرافية
العنوان: Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer.
المؤلفون: Wang Y; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Nguyen LH; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Mehta RS; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Song M; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston.; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Huttenhower C; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts., Chan AT; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston.; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
المصدر: JAMA network open [JAMA Netw Open] 2021 Nov 01; Vol. 4 (11), pp. e2134308. Date of Electronic Publication: 2021 Nov 01.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Medical Association Country of Publication: United States NLM ID: 101729235 Publication Model: Electronic Cited Medium: Internet ISSN: 2574-3805 (Electronic) Linking ISSN: 25743805 NLM ISO Abbreviation: JAMA Netw Open Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Chicago, IL : American Medical Association, [2018]-
مواضيع طبية MeSH: Sulfur-Reducing Bacteria*, Colorectal Neoplasms/*epidemiology , Diet/*adverse effects , Diet, Healthy/*statistics & numerical data , Sulfur/*metabolism, Adult ; Aged ; Caloric Restriction/adverse effects ; Colorectal Neoplasms/etiology ; Diet/methods ; Diet Surveys ; Feces/microbiology ; Feeding Behavior/physiology ; Female ; Follow-Up Studies ; Fruit ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Prospective Studies ; Red Meat/adverse effects ; Risk Factors ; Vegetables
مستخلص: Importance: Sulfur-metabolizing bacteria that reduce dietary sulfur to hydrogen sulfide have been associated with colorectal cancer (CRC). However, there are limited studies investigating the association between diet and sulfur-metabolizing bacteria in the development of CRC.
Objective: To develop a dietary score that correlates with gut sulfur-metabolizing bacteria and to examine its association with CRC risk.
Design, Setting, and Participants: This prospective cohort study included data from the Health Professionals Follow-up Study (1986-2014), Nurses' Health Study (1984-2016), and Nurses' Health Study II (1991-2017). Participants were US male health professionals and female registered nurses who were free of inflammatory bowel disease and cancer at baseline, with a subsample of participants who provided stool samples from 2012 to 2014. Statistical analysis was conducted from September 1, 2020, to June 1, 2021.
Exposure: A dietary pattern, assessed by a food-frequency questionnaire, that most correlated with 43 sulfur-metabolizing bacteria identified through taxonomic and functional profiling of gut metagenome data.
Main Outcomes and Measures: Incident CRC.
Results: Among 214 797 participants comprising 46 550 men (mean [SD] age at baseline, 54.3 [9.7] years) and 168 247 women (mean [SD] age at baseline, 43.0 [9.2] years), 3217 incident cases of CRC (1.5%) were documented during 5 278 048 person-years of follow-up. The sulfur microbial diet, developed in a subsample of 307 men (mean [SD] age, 70.5 [4.3] years) and 212 women (mean [SD] age, 61.0 [3.8] years), was characterized by high intakes of low-calorie beverages, french fries, red meats, and processed meats and low intakes of fruits, yellow vegetables, whole grains, legumes, leafy vegetables, and cruciferous vegetables. After adjustment for other risk factors, greater adherence to the sulfur microbial diet was associated with an increased risk of CRC, with a hazard ratio (HR) of 1.27 (95% CI, 1.12-1.44) comparing the highest vs the lowest quintile of the diet score (linear trend of diet score quintiles; P < .001 for trend). When assessed by anatomical subsites, greater adherence to the sulfur microbial diet was positively associated with distal CRC (HR, 1.25; 95% CI, 1.05-1.50; P = .02 for trend) but not proximal colon cancer (HR, 1.13; 95% CI, 0.93-1.39; P = .19 for trend).
Conclusions and Relevance: Adherence to the sulfur microbial diet was associated with an increased risk of CRC, suggesting a potential mediating role of sulfur-metabolizing bacteria in the associaton between diet and CRC. Further research is needed to confirm these findings and to determine the underlying mechanisms.
References: Genome Biol. 2015 Apr 08;16:73. (PMID: 25888008)
Phytother Res. 2012 May;26(5):743-7. (PMID: 22076869)
Lancet. 2000 Aug 26;356(9231):724-9. (PMID: 11085692)
CA Cancer J Clin. 2021 May;71(3):209-249. (PMID: 33538338)
Bioinformatics. 2018 Apr 1;34(7):1235-1237. (PMID: 29194469)
Am J Clin Nutr. 2000 Oct;72(4):912-21. (PMID: 11010931)
Sci Rep. 2020 May 20;10(1):8311. (PMID: 32433513)
Biostatistics. 2013 Apr;14(2):244-58. (PMID: 23074263)
Sci Rep. 2016 Feb 15;6:20831. (PMID: 26877209)
Trends Mol Med. 2016 Mar;22(3):190-199. (PMID: 26852376)
PLoS One. 2018 Jul 19;13(7):e0199244. (PMID: 30024889)
BMJ. 2016 Jan 28;352:i17. (PMID: 26823518)
Gut. 2010 Dec;59(12):1670-9. (PMID: 20844293)
World J Gastroenterol. 2015 May 7;21(17):5167-75. (PMID: 25954090)
Front Oncol. 2020 Dec 09;10:607909. (PMID: 33363037)
Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2329-38. (PMID: 24843156)
Am J Clin Nutr. 2000 Dec;72(6):1488-94. (PMID: 11101476)
Am J Clin Nutr. 1999 Feb;69(2):243-9. (PMID: 9989687)
Mol Cancer Res. 2007 May;5(5):455-9. (PMID: 17475672)
Am J Epidemiol. 2017 Apr 1;185(7):570-584. (PMID: 28338828)
Gastroenterology. 2020 Apr;158(5):1313-1325. (PMID: 31972239)
Nat Microbiol. 2018 Mar;3(3):347-355. (PMID: 29335554)
Lancet. 1991 Aug 24;338(8765):464-8. (PMID: 1678444)
Nutr Neurosci. 2020 Apr 16;:1-15. (PMID: 32297553)
Nature. 2014 Jan 23;505(7484):559-63. (PMID: 24336217)
Drug Metab Rev. 2004 Oct;36(3-4):655-67. (PMID: 15554241)
Cancer Res. 2017 Jun 15;77(12):3352-3363. (PMID: 28416481)
Gastroenterology. 2014 Aug;147(2):351-8; quiz e14–5. (PMID: 24786894)
mSystems. 2016 May 3;1(3):. (PMID: 27822526)
Am J Epidemiol. 2006 Dec 1;164(11):1085-93. (PMID: 16990408)
J Clin Oncol. 2009 Feb 10;27(5):686-93. (PMID: 19114701)
Gastroenterology. 2015 May;148(6):1244-60.e16. (PMID: 25575572)
Br J Cancer. 2021 Sep;125(7):1016-1024. (PMID: 34267328)
Gut Microbes. 2019;10(4):447-457. (PMID: 30810441)
JAMA. 1997 Oct 1;278(13):1078-83. (PMID: 9315766)
Dis Colon Rectum. 2010 Jan;53(1):57-64. (PMID: 20010352)
Gastroenterology Res. 2018 Aug;11(4):264-273. (PMID: 30116425)
Cell Host Microbe. 2015 Feb 11;17(2):260-73. (PMID: 25662751)
Ann Oncol. 2013 Apr;24(4):1079-87. (PMID: 23211939)
Nutrients. 2020 Jul 15;12(7):. (PMID: 32679670)
Mol Metab. 2018 Sep;15:45-55. (PMID: 29858147)
Biostatistics. 2009 Jul;10(3):515-34. (PMID: 19377034)
Cancer Causes Control. 2019 Jul;30(7):779-790. (PMID: 31049751)
معلومات مُعتمدة: P30 DK043351 United States DK NIDDK NIH HHS
المشرفين على المادة: 70FD1KFU70 (Sulfur)
تواريخ الأحداث: Date Created: 20211112 Date Completed: 20220111 Latest Revision: 20220125
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8590167
DOI: 10.1001/jamanetworkopen.2021.34308
PMID: 34767023
قاعدة البيانات: MEDLINE
الوصف
تدمد:2574-3805
DOI:10.1001/jamanetworkopen.2021.34308