دورية أكاديمية
Increase in the Antioxidant and Anti-Inflammatory Activity of Euterpe oleracea Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin.
العنوان: | Increase in the Antioxidant and Anti-Inflammatory Activity of Euterpe oleracea Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin. |
---|---|
المؤلفون: | de Almeida Magalhães TSS; Laboratório Escola de Farmácia Industrial, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Oliveira Macedo PC; Laboratório Escola de Farmácia Industrial, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., da Costa ÉCP; Laboratório Escola de Farmácia Industrial, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Aragão Tavares E; Centro de Biociências, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., da Silva VC; Centro de Biociências, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., Guerra GCB; Centro de Biociências, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., Pereira JR; Laboratório de Pesquisa em Bioquímica Clínica e Experimental, Department of Análises Clínicas e Toxicológicas, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Araújo Moura Lemos TM; Laboratório de Pesquisa em Bioquímica Clínica e Experimental, Department of Análises Clínicas e Toxicológicas, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Negreiros MMF; Department of Biochemistry, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., de Oliveira Rocha HA; Department of Biochemistry, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., Converti A; Department of Civil, Chemical and Environmental Engineering, Pole of Chemical Engineering, Genoa University, I-16145 Genoa, Italy., de Lima ÁAN; Laboratório Escola de Farmácia Industrial, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil. |
المصدر: | International journal of molecular sciences [Int J Mol Sci] 2021 Oct 26; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 26. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI, [2000- |
مواضيع طبية MeSH: | Euterpe/*chemistry , Plant Oils/*chemistry , Plant Oils/*pharmacology, 2-Hydroxypropyl-beta-cyclodextrin/administration & dosage ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/administration & dosage ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Edema/drug therapy ; Female ; In Vitro Techniques ; Male ; Mice ; Phytochemicals/administration & dosage ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Plant Oils/administration & dosage ; Plants, Medicinal/chemistry ; beta-Cyclodextrins/administration & dosage |
مستخلص: | Reactive oxygen species (ROS) are aerobic products generated during cellular respiration, but in the case of oxidative stress, they become key factors in the development of inflammatory processes and chronic diseases such as diabetes and rheumatoid arthritis. In this work, Euterpe oleracea oil (EOO), as well as the complexes produced by slurry (S) and kneading (K), were analyzed for antioxidant capacity in vitro, while only the β-cyclodextrin complex obtained by kneading (EOO-βCD-K), which showed better complexation, was selected for anti-inflammatory assays in vivo. In the scavenging activity of OH·, the hydroxypropyl-β-cyclodextrin complex obtained by kneading (EOO-HPβCD-K) exhibited an activity 437% higher than the pure oil. In the paw edema assay, EOO-βCD-K reduced edema by 200% and myeloperoxidase (MPO) activity by 112%. In an air pouch model, this treatment showed a reduction in leukocyte, MPO, and Interleukin-1β (IL-1β) levels; meanwhile those of glutathione and IL-10 were increased, demonstrating its ability to potentiate the anti-inflammatory effect of EOO. |
References: | Free Radic Biol Med. 1997;22(5):749-60. (PMID: 9119242) Nat Rev Rheumatol. 2015 May;11(5):265-75. (PMID: 25512012) Diabetes Metab Res Rev. 2008 Nov-Dec;24(8):595-603. (PMID: 18756581) Inflamm Res. 1999 Mar;48(3):139-48. (PMID: 10219656) Spectrochim Acta A Mol Biomol Spectrosc. 2008 Nov 1;71(1):269-75. (PMID: 18262835) Biomolecules. 2020 May 26;10(6):. (PMID: 32466439) Phytomedicine. 2012 Feb 15;19(3-4):262-9. (PMID: 22138278) Antioxid Redox Signal. 2014 Mar 1;20(7):1126-67. (PMID: 23991888) Food Chem. 2015 Jul 15;179:137-51. (PMID: 25722148) Mar Drugs. 2018 Apr 20;16(4):. (PMID: 29677120) Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11961-6. (PMID: 11593004) Gastroenterology. 1984 Dec;87(6):1344-50. (PMID: 6092199) Cell Mol Biol (Noisy-le-grand). 2001 Jun;47(4):695-702. (PMID: 11502077) Oncotarget. 2017 Dec 14;9(6):7204-7218. (PMID: 29467962) Eur J Pharm Sci. 2019 Feb 1;128:158-161. (PMID: 30508582) Int J Mol Sci. 2017 Nov 18;18(11):. (PMID: 29156553) Int J Mol Sci. 2020 Jan 31;21(3):. (PMID: 32023867) Biomed Pharmacother. 2016 Dec;84:454-461. (PMID: 27685788) J Agric Food Chem. 2012 Feb 1;60(4):1084-93. (PMID: 22224493) Phytochemistry. 2015 Jun;114:125-36. (PMID: 25457483) J Pharm Biomed Anal. 2017 Feb 20;135:153-159. (PMID: 28027523) Biochemistry (Mosc). 2004 Jan;69(1):4-9. (PMID: 14972011) Eur J Med Chem. 2017 Jun 16;133:379-402. (PMID: 28415050) Molecules. 2007 Aug 06;12(8):1679-719. (PMID: 17960082) Biomed Pharmacother. 2017 May;89:201-207. (PMID: 28226293) Food Chem. 2017 Feb 15;217:364-372. (PMID: 27664647) Int J Antimicrob Agents. 2003 Apr;21(4):334-9. (PMID: 12672579) Biomed Pharmacother. 2017 Apr;88:1122-1144. (PMID: 28208574) Proc Soc Exp Biol Med. 1962 Dec;111:544-7. (PMID: 14001233) Anal Biochem. 1968 Oct 24;25(1):192-205. (PMID: 4973948) Food Chem. 2018 Apr 15;245:1062-1069. (PMID: 29287323) Saudi Pharm J. 2013 Apr;21(2):143-52. (PMID: 24936134) J Agric Food Chem. 2008 May 28;56(10):3593-600. (PMID: 18442253) Asian J Pharm Sci. 2017 Mar;12(2):187-192. (PMID: 32104329) Int J Mol Sci. 2012;13(3):3145-75. (PMID: 22489146) Food Chem Toxicol. 2017 Nov;109(Pt 2):836-846. (PMID: 28235614) Int J Mol Sci. 2021 Sep 13;22(18):. (PMID: 34576044) J Radiat Res. 2009 Jul;50(4):303-9. (PMID: 19461166) Biomed Pharmacother. 2017 Sep;93:754-762. (PMID: 28704800) Compr Rev Food Sci Food Saf. 2016 Jul;15(4):720-738. (PMID: 33401843) Antioxid Redox Signal. 2009 Nov;11(11):2899-937. (PMID: 19622015) Biomed Pharmacother. 2018 May;101:805-819. (PMID: 29525677) Clin Biochem. 1990 Dec;23(6):501-4. (PMID: 2289307) Neuropharmacology. 2005 Sep;49(3):275-82. (PMID: 15922370) Arthritis Care Res (Hoboken). 2019 Feb;71(2):173-177. (PMID: 30295435) J Agric Food Chem. 2008 Jun 25;56(12):4631-6. (PMID: 18522407) |
معلومات مُعتمدة: | 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior |
فهرسة مساهمة: | Keywords: Euterpe oleraceae; anti-inflammatory; antioxidant; inclusion complexes |
المشرفين على المادة: | 0 (Anti-Inflammatory Agents) 0 (Antioxidants) 0 (Phytochemicals) 0 (Plant Oils) 0 (beta-Cyclodextrins) 1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin) |
تواريخ الأحداث: | Date Created: 20211113 Date Completed: 20211216 Latest Revision: 20211216 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8584258 |
DOI: | 10.3390/ijms222111524 |
PMID: | 34768954 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1422-0067 |
---|---|
DOI: | 10.3390/ijms222111524 |