دورية أكاديمية
أعرض في EDS

Increase in the Antioxidant and Anti-Inflammatory Activity of Euterpe oleracea Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin.

التفاصيل البيبلوغرافية
العنوان: Increase in the Antioxidant and Anti-Inflammatory Activity of Euterpe oleracea Martius Oil Complexed in β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin.
المؤلفون: de Almeida Magalhães TSS; Laboratório Escola de Farmácia Industrial, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Oliveira Macedo PC; Laboratório Escola de Farmácia Industrial, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., da Costa ÉCP; Laboratório Escola de Farmácia Industrial, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Aragão Tavares E; Centro de Biociências, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., da Silva VC; Centro de Biociências, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., Guerra GCB; Centro de Biociências, Department of Biophysics and Pharmacology, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., Pereira JR; Laboratório de Pesquisa em Bioquímica Clínica e Experimental, Department of Análises Clínicas e Toxicológicas, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Araújo Moura Lemos TM; Laboratório de Pesquisa em Bioquímica Clínica e Experimental, Department of Análises Clínicas e Toxicológicas, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Negreiros MMF; Department of Biochemistry, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., de Oliveira Rocha HA; Department of Biochemistry, Federal University of Rio Grande do Norte, Natal 59078-570, Brazil., Converti A; Department of Civil, Chemical and Environmental Engineering, Pole of Chemical Engineering, Genoa University, I-16145 Genoa, Italy., de Lima ÁAN; Laboratório Escola de Farmácia Industrial, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Oct 26; Vol. 22 (21). Date of Electronic Publication: 2021 Oct 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Euterpe/*chemistry , Plant Oils/*chemistry , Plant Oils/*pharmacology, 2-Hydroxypropyl-beta-cyclodextrin/administration & dosage ; Animals ; Anti-Inflammatory Agents/administration & dosage ; Anti-Inflammatory Agents/chemistry ; Anti-Inflammatory Agents/pharmacology ; Antioxidants/administration & dosage ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Edema/drug therapy ; Female ; In Vitro Techniques ; Male ; Mice ; Phytochemicals/administration & dosage ; Phytochemicals/chemistry ; Phytochemicals/pharmacology ; Plant Oils/administration & dosage ; Plants, Medicinal/chemistry ; beta-Cyclodextrins/administration & dosage
مستخلص: Reactive oxygen species (ROS) are aerobic products generated during cellular respiration, but in the case of oxidative stress, they become key factors in the development of inflammatory processes and chronic diseases such as diabetes and rheumatoid arthritis. In this work, Euterpe oleracea oil (EOO), as well as the complexes produced by slurry (S) and kneading (K), were analyzed for antioxidant capacity in vitro, while only the β-cyclodextrin complex obtained by kneading (EOO-βCD-K), which showed better complexation, was selected for anti-inflammatory assays in vivo. In the scavenging activity of OH·, the hydroxypropyl-β-cyclodextrin complex obtained by kneading (EOO-HPβCD-K) exhibited an activity 437% higher than the pure oil. In the paw edema assay, EOO-βCD-K reduced edema by 200% and myeloperoxidase (MPO) activity by 112%. In an air pouch model, this treatment showed a reduction in leukocyte, MPO, and Interleukin-1β (IL-1β) levels; meanwhile those of glutathione and IL-10 were increased, demonstrating its ability to potentiate the anti-inflammatory effect of EOO.
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معلومات مُعتمدة: 001 Coordenação de Aperfeicoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: Euterpe oleraceae; anti-inflammatory; antioxidant; inclusion complexes
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antioxidants)
0 (Phytochemicals)
0 (Plant Oils)
0 (beta-Cyclodextrins)
1I96OHX6EK (2-Hydroxypropyl-beta-cyclodextrin)
تواريخ الأحداث: Date Created: 20211113 Date Completed: 20211216 Latest Revision: 20211216
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8584258
DOI: 10.3390/ijms222111524
PMID: 34768954
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms222111524