دورية أكاديمية
Structural and mutational analysis of member-specific STAT functions.
| العنوان: | Structural and mutational analysis of member-specific STAT functions. |
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| المؤلفون: | Erdogan F; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada., Qadree AK; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada., Radu TB; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada., Orlova A; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, A-1210 Vienna, Austria., de Araujo ED; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada., Israelian J; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada., Valent P; Department of Internal Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria., Mustjoki SM; Hematology Research Unit, Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland; Translational Immunology Research Program and Department of Clinical Chemistry and Hematology, University of Helsinki, Helsinki, Finland; iCAN Digital Precision Cancer Medicine Flagship, Helsinki, Finland., Herling M; Department of Hematology, Cellular Therapy, and Hemostaseology, University of Leipzig, Leipzig, Germany., Moriggl R; Institute of Animal Breeding and Genetics, University of Veterinary Medicine, A-1210 Vienna, Austria., Gunning PT; Department of Chemical and Physical Sciences, University of Toronto Mississauga, 3359 Mississauga Rd N., Mississauga, Canada; Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada. Electronic address: patrick.gunning@utoronto.ca. |
| المصدر: | Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2022 Mar; Vol. 1866 (3), pp. 130058. Date of Electronic Publication: 2021 Nov 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731726 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8006 (Electronic) Linking ISSN: 03044165 NLM ISO Abbreviation: Biochim Biophys Acta Gen Subj Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier |
| مواضيع طبية MeSH: | STAT Transcription Factors* |
| مستخلص: | Background: The STAT family of transcription factors control gene expression in response to signals from various stimulus. They display functions in diseases ranging from autoimmunity and chronic inflammatory disease to cancer and infectious disease. Scope of Review: This work uses an approach informed by structural data to explore how domain-specific structural variations, post-translational modifications, and the cancer genome mutational landscape dictate STAT member-specific activities. Major Conclusions: We illustrated the structure-function relationship of STAT proteins and highlighted their effect on member-specific activity. We correlated disease-linked STAT mutations to the structure and cancer genome mutational landscape and proposed rational drug targeting approaches of oncogenic STAT pathway addiction. General Significance: Hyper-activated STATs and their variants are associated with multiple diseases and are considered high value oncology targets. A full understanding of the molecular basis of member-specific STAT-mediated signaling and the strategies to selectively target them requires examination of the difference in their structures and sequences. (Copyright © 2021. Published by Elsevier B.V.) |
| معلومات مُعتمدة: | I 4157 Austria FWF_ Austrian Science Fund FWF |
| فهرسة مساهمة: | Keywords: Disease-linked mutations; JAK-STAT role in cancer; Post-translation modifications; Protein interaction interfaces; STAT family of proteins; Structure-function relationship |
| المشرفين على المادة: | 0 (STAT Transcription Factors) |
| تواريخ الأحداث: | Date Created: 20211114 Date Completed: 20220216 Latest Revision: 20231115 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.bbagen.2021.130058 |
| PMID: | 34774983 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-8006 |
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| DOI: | 10.1016/j.bbagen.2021.130058 |