دورية أكاديمية
أعرض في EDS

Simultaneous occurrence of Epstein-Barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study.

التفاصيل البيبلوغرافية
العنوان: Simultaneous occurrence of Epstein-Barr virus (EBV) in periodontal pockets and in oral squamous cell carcinoma: a cross-sectional study.
المؤلفون: Jácome-Santos H; Laboratory of Pathology and Immunohistochemistry (LAPI), School of Dentistry, Universidade Federal do Pará (UFPA), Belém, PA, Brazil. humbertoufpa@yahoo.com.br.; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil. humbertoufpa@yahoo.com.br., da Silva E Silva N; Department of Virology, Laboratory of Epstein-Barr Virus, Instituto Evandro Chagas (IEC), Belém, PA, Brazil., Resende RG; Department of Stomatology & Oral and Maxillofacial Surgery, Hospital Metropolitano Odilon Behrens (HMOB), Belo Horizonte, MG, Brazil., Costa Pinheiro HH; Laboratory of Pathology and Immunohistochemistry (LAPI), School of Dentistry, Universidade Federal do Pará (UFPA), Belém, PA, Brazil., Almeida Machado LF; Laboratory of Virology, Universidade Federal do Pará (UFPA), Belém, PA, Brazil., de Souza Silva G; Hospital das Clínicas (HC), Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., de Oliveira Costa F; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., Brasil-Costa I; Laboratory of Virology, Universidade Federal do Pará (UFPA), Belém, PA, Brazil., Amoras-Alves ACB; Laboratory of Pathology and Immunohistochemistry (LAPI), School of Dentistry, Universidade Federal do Pará (UFPA), Belém, PA, Brazil., Mesquita RA; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil., de Melo Alves-Junior S; Laboratory of Pathology and Immunohistochemistry (LAPI), School of Dentistry, Universidade Federal do Pará (UFPA), Belém, PA, Brazil.
المصدر: Clinical oral investigations [Clin Oral Investig] 2022 Mar; Vol. 26 (3), pp. 2807-2815. Date of Electronic Publication: 2021 Nov 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 9707115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1436-3771 (Electronic) Linking ISSN: 14326981 NLM ISO Abbreviation: Clin Oral Investig
أسماء مطبوعة: Publication: Berlin : Springer-Verlag
Original Publication: Berlin : Springer, c1997-
مواضيع طبية MeSH: Carcinoma, Squamous Cell*/genetics , Epstein-Barr Virus Infections* , Head and Neck Neoplasms* , Mouth Neoplasms*/genetics, Adult ; Aged ; Aged, 80 and over ; Cross-Sectional Studies ; Female ; Herpesvirus 4, Human/genetics ; Humans ; Male ; Middle Aged ; Periodontal Pocket ; Quality of Life ; Squamous Cell Carcinoma of Head and Neck
مستخلص: Objectives: This study aimed to investigate the detection of Epstein-Barr virus (EBV) in oral squamous cell carcinoma (OSCC) and to verify the concordance of EBV-DNA frequency in subgingival sites and in the OSCC.
Methods: A cross-sectional study with 30 OSCC patients, aged from 44 to 88 years old, was conducted. Samples were collected in subgingival sites and at the OSCC, then submitted to DNA isolation, qPCR, and genotyping. Descriptive statistic was performed to report the frequency of EBV-DNA in all samples, and McNemar test was applied to verify the concordance among the EBV-DNA frequency in both sites.
Results: The individuals presented 62 years old in average, and the majority were male (66.6%). EBV-DNA was detected in 56.7% OSCC lesions. Among the subgroup of 19 dentate individuals, high concordance (73.7%) in both EBV-DNA detection and the absence in subgingival sites and OSCC was observed, and it was statistically significant (p < 0.05).
Conclusions: We report the notable occurrence of EBV-DNA in OSCC; also, the presence of EBV in periodontal sites may contribute to find it in OSCC, although the possible contribution of EBV in the OSCC remains to be investigated.
Clinical Relevance: The identification of this easily accessible site of EBV latent infection may help to improve the patient's quality of life by maintenance of oral/periodontal health condition and preventing further possible disorders related to the virus, and also encourages new approaches for investigating EBV, periodontitis, and OSCC.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
References: Thomson PJ (2018) Perspectives on oral squamous cell carcinoma prevention- proliferation, position, progression and prediction. J Oral Pathol Med 47:803–807. https://doi.org/10.1111/jop.12733. (PMID: 10.1111/jop.1273329752860)
Feller L, Lemmer J (2012) Oral squamous cell carcinoma: epidemiology, clinical presentation and treatment. J Cancer Ther 3:263–268. https://doi.org/10.4236/jct.2012.34037. (PMID: 10.4236/jct.2012.34037)
Warnakulasuriya S (2009) Global epidemiology of oral and oropharyngeal cancer. Oral Oncol 45:309–316. https://doi.org/10.1016/j.oraloncology.2008.06.002. (PMID: 10.1016/j.oraloncology.2008.06.00218804401)
INCA- Instituto Nacional de Câncer José Alencar Gomes da Silva– INCA. Estimativa 2018/2019: incidência de câncer no Brasil. Rio de Janeiro: INCA, 2018. http://www1.inca.gov.br/rbc/n&#95;64/v01/pdf/15-resenha-estimativa-2018-incidencia-de-cancer-no-brasil.pdf.
Zhong LP, Zhang CP, Ren GX, Guo W, William WN Jr, Hong CS, Sun J, Zhu HG, Tu WY, Li J, Cai YL, Yin QM, Wang LZ, Wang ZH, Hu YJ, Ji T, Yang WJ, Ye WM, Li J, He Y, Wang YA, Xu LQ, Zhuang Z, Lee JJ, Myers JN, Zhang ZY (2015) Long-term results of a randomized phase III trial of TPF induction chemotherapy followed by surgery and radiation in locally advanced oral squamous cell carcinoma. Oncotarget 30:18707–18714. https://doi.org/10.18632/oncotarget.4531. (PMID: 10.18632/oncotarget.4531)
Chin D, Boyle GM, Porceddu S, Theile DR, Parsons PG, Coman WB (2006) Head and neck cancer: past, present and future. Expert Rev Anticancer Ther 6:1111–1118. https://doi.org/10.1586/14737140.6.7.1111. (PMID: 10.1586/14737140.6.7.111116831082)
Gallimidi AB, Fischman S, Revach B, Bulvik R, Maliutina A, Rubinstein AM, Nussbaum G, Elkin M (2015) Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model. Oncotarget 6:22613–22623. https://doi.org/10.18632/oncotarget.4209. (PMID: 10.18632/oncotarget.42094673186)
Gupta K, Metgud R (2013) Evidences suggesting involvement of viruses in oral squamous cell carcinoma. Patholog Res Int 2013:642496. https://doi.org/10.1155/2013/642496. (PMID: 10.1155/2013/642496244554183880768)
Higa M, Kinjo T, Kamiyama K, Chinen K, Iwamasa T, Arasaki A, Sunakawa H (2003) Epstein-Barr virus (EBV)-related oral squamous cell carcinoma in Okinawa, a subtropical island, in southern Japan- simultaneously infected with human papillomavirus (HPV). Oral Oncol 39:405–414. https://doi.org/10.1016/s1368-8375(02)00164-1. (PMID: 10.1016/s1368-8375(02)00164-112676263)
Sand L, Jalouli J (2014) Viruses and oral cancer. is there a link? Microbes Infect 16:371–378. https://doi.org/10.1016/j.micinf.2014.02.009. (PMID: 10.1016/j.micinf.2014.02.00924613199)
Prabhu SR, Wilson DF (2016) Evidence of Epstein-Barr virus association with head and neck cancers: a review. J Can Dent Assoc 82:g2. (PMID: 27548665)
Tsao SW, Tsang CM, Lo KW (2017) Epstein-Barr virus infection and nasopharyngeal carcinoma. Philos Trans R Soc Lond B Biol Sci 372:20160270. https://doi.org/10.1098/rstb.2016.0270. (PMID: 10.1098/rstb.2016.0270288939375597737)
Takada K (2000) Epstein-Barr virus and gastric carcinoma. Mol Pathol 53:255–256. https://doi.org/10.1136/mp.53.5.255. (PMID: 10.1136/mp.53.5.255110918491186978)
She Y, Nong X, Zhang M (2017) Wang M (2017) Epstein-Barr virus infection and oral squamous cell carcinoma risk: a meta-analysis. PLoS ONE 12:e0186860. https://doi.org/10.1371/journal.pone.0186860.eCollection. (PMID: 10.1371/journal.pone.0186860.eCollection290651915655447)
Tsao SW, Tsang CM, Pang PS, Zhang G, Chen H, Lo KW (2012) The biology of EBV infection in human epithelial cells. Semin Cancer Biol 22:137–143. https://doi.org/10.1016/j.semcancer.2012.02.004. (PMID: 10.1016/j.semcancer.2012.02.00422497025)
Hadinoto V, Shapiro M, Sun CC, Thorley-Lawson DA (2009) The dynamics of EBV shedding implicate a central role for epithelial cells in amplifying viral output. PLoS Pathog 5:e1000496. https://doi.org/10.1371/journal.ppat.1000496. (PMID: 10.1371/journal.ppat.1000496195784332698984)
Gao Z, Lv J, Wang M (2017) Epstein-Barr virus is associated with periodontal diseases: A meta-analysis based on 21 case-control studies. Medicine (Baltimore) 96:e5980. https://doi.org/10.1097/MD.0000000000005980. (PMID: 10.1097/MD.0000000000005980)
Agar N, Patel R (2014) Early detection causes and screening of oral cancer. JSM Dent 2:1039.
Tonetti MS, Greenwell H, Kornman KS (2018) Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Clin Periodontol 45:S149–S161. (PMID: 10.1111/jcpe.12945)
Scheutz F, Matee MI, Andsager L, Holm AM, Moshi J, Kagoma C, Mpemba N (1997) Is there an association between periodontal condition and HIV infection. J Clin Periodontol 24:580–587. https://doi.org/10.1111/j.1600-051x.1997.tb00232.x. (PMID: 10.1111/j.1600-051x.1997.tb00232.x9266346)
Howlett SE, Castillo HS, Gioeni LJ, Lora J, Robertson JM, Donfack J (2014) Evaluation of DNAstable™ for DNA storage at ambient temperature. Forensic Sci Int Genet 8:170–178. https://doi.org/10.1016/j.fsigen.2013.09.003. (PMID: 10.1016/j.fsigen.2013.09.00324315605)
Mesri EA, Feitelson MA, Munger K (2014) Human viral oncogenesis: a cancer hallmarks analysis. Cell Host Microbe 15:266–282. https://doi.org/10.1016/j.chom.2014.02.011. (PMID: 10.1016/j.chom.2014.02.011246293343992243)
Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Benbrahim- Tallaa L, Guha N, Freeman C, Galichet L, Cogliano V (2009) WHO International Agency for Research on Cancer Monograph Working Group. a review of human carcinogens- Part B: biological agents. Lancet Oncol 10:321–322. https://doi.org/10.1016/s1470-2045(09)70096-8. (PMID: 10.1016/s1470-2045(09)70096-819350698)
Cordero OJ, Varela-Calvino R (2018) Oral hygiene might prevent cancer. Heliyon 4:e00879. https://doi.org/10.1016/j.heliyon.2018.e00879. (PMID: 10.1016/j.heliyon.2018.e00879304171456218413)
D’Costa J, Saranath D, Sanghvi V, Mehta AR (1998) Epstein-Barr virus in tobacco-induced oral cancers and oral lesions in patients from India. J Oral Pathol Med 27:78–82. https://doi.org/10.1111/j.1600-0714.1998.tb02098.x. (PMID: 10.1111/j.1600-0714.1998.tb02098.x9526734)
Kikuchi K, Noguchi Y, Garcia-Nino de Rivera MW, Hoshino M, Sakashita H, Yamada T, Inoue H, Miyazaki Y, Nozaki T, González-López BS, Ide F, Kusama K (2016) Detection of Epstein-Barr virus genome and latent infection gene expression in normal epithelia, epithelial dysplasia, and squamous cell carcinoma of the oral cavity. Tumor Biol 37:3389–3404. https://doi.org/10.1007/s13277-015-4167-7. (PMID: 10.1007/s13277-015-4167-7)
Kikuchi K, Inoue H, Miyazaki Y, Ide F, Kojima M, Kusama K (2017) Epstein-Barr virus (EBV)-associated epithelial and non-epithelial lesions of the oral cavity. Jpn Dent Sci Rev 53:95–109. https://doi.org/10.1016/j.jdsr.2017.01.002. (PMID: 10.1016/j.jdsr.2017.01.002287253005501733)
Srivastava AK, Shukla S, Srivastava P, Dhole TN, Nayak MT, Nayak A, Mathur A (2019) Real time detection and quantification of Epstein Barr virus in different grades of oral gingivitis and periodontitis patients. J Exp Ther Oncol 13:9–14. (PMID: 30658021)
Kiprian D, Czarkowska-Paczek B, Wyczalkowska-Tomasik A, Paczek L (2018) Human cytomegalovirus and Epstein-Barr virus infections increase the risk of death in patients with head and neck cancers receiving radiotherapy or radiochemotherapy. Medicine (Baltimore) 97:e13777. https://doi.org/10.1097/MD.0000000000013777. (PMID: 10.1097/MD.0000000000013777)
Van Rensburg EJ, Engelbrecht S, Van HW, Raubenheimer E, Schoub BD (1995) Detection of EBV DNA in oral squamous cell carcinomas in a black African population sample. In Vivo (Athens Greece) 9:199–202.
Cruz I, Van den Brule AJ, Steenbergen RD, Snijders PJ, Meijer CJ, Walboomers JM, Snow GB, Van der Waal I (1997) Prevalence of Epstein-Barr virus in oral squamous cell carcinomas, premalignant lesions and normal mucosa — a study using the polymerase chain reaction. Oral Oncol 33:182–188. https://doi.org/10.1016/s0964-1955(96)00054-1. (PMID: 10.1016/s0964-1955(96)00054-19307727)
Kiryanov SA, Levina TA, Polyakov AP, Rebrikova IV, Murashko DA, Konopleva MV, Semenenko TA, Suslov AP (2019) Detection of Epstein-Barr virus genome in oral cavity squamous cell carcinoma samples of Russian patients. Vopr Virusol 64:112–117. https://doi.org/10.18821/0507-4088-2019-64-3-112-117. (PMID: 10.18821/0507-4088-2019-64-3-112-11731622057)
Sample J, Young L, Martin B, Chatman T, Kieff E, Rickinson A, Kieff E (1990) Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. J Virol 64:4084–4092. https://doi.org/10.1128/JVI.64.9.4084-4092.1990. (PMID: 10.1128/JVI.64.9.4084-4092.19902166806247870)
Zimber U, Adldinger HK, Lenoir GM, Vuillaume M, Knebel-Doeberitz MV, Laux G, Desgranges C, Wittmann P, Freese UK, Schneider U, Bornkamm GW (1986) Geographical prevalence of two types ofEpstein-Barr virus. Virology 154:56–66. https://doi.org/10.1016/0042-6822(86)90429-0. (PMID: 10.1016/0042-6822(86)90429-03019008)
Smith NA, Baresel PC, Jackson CL, Ogolla S, Toko EN, Heit S, Piriou E, Sumba OP, Middeldrop JM, Colborn KL, Rochford R (2019) Differences in the Epstein-Barr virus gp350 IgA antibody response are associated with increased risk for coinfection with a second strain of Epstein-Barr Virus. J Infect Dis 219:955–963. https://doi.org/10.1093/infdis/jiy601. (PMID: 10.1093/infdis/jiy60130312417)
Lung ML, Li SB, Chang RS (1991) Study of Epstein-Barr virus (EBV) transmission by EBV genotyping. J Infect Dis 164:213–214. https://doi.org/10.1093/infdis/164.1.213. (PMID: 10.1093/infdis/164.1.2131647423)
Lucchesi W, Brady G, Dittrich-Breiholz O, Kracht M, Russ R, Farrell PJ (2008) Differential gene regulation by Epstein-Barr virus type 1 and type 2 EBNA2. J Virol 82:7456–7466. https://doi.org/10.1128/jvi.00223-08. (PMID: 10.1128/jvi.00223-08184804452493322)
Rickinson AB, Young LS, Rowe M (1987) Influence of the Epstein-Barr virus nuclear antigen EBNA 2 on the growth phenotype of virus-transformed B cells. J Virol 61:1310–1317. https://doi.org/10.1128/JVI.61.5.1310-1317.1987. (PMID: 10.1128/JVI.61.5.1310-1317.19873033261254104)
IARC (International Agency for Research on Cancer) Working Group on the Evaluation of Carcinogenic Risks to Humans. Epstein–Barr virus. In: a review of human carcinogens. B. Biological agents. IARC monograph on the evaluation of carcinogenic risks to humans 100(B). Lyon, France: IARC; 2012. p. 49–92.
Bouvard V, Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F et al (2009) A review of human carcinogenesis — part B: biological agents. Lancet Oncol 10:321–322. (PMID: 10.1016/S1470-2045(09)70096-8)
Griffin BE (2000) Epstein-Barr virus (EBV) and human disease: facts, opinions and problems. Mutat Res 462:395–405. (PMID: 10.1016/S1383-5742(00)00028-4)
Parkin DM (2011) Cancers attributable to infection in the UK in 2010. Br J Cancer 105(suppl 2):S49-56. (PMID: 10.1038/bjc.2011.484)
IARC (International Agency for Research on Cancer) (1997) Working Group on the Evaluation of Carcinogenic Risks to Humans. Nasopharyngeal carcinoma. In: Epstein-Barr virus and Kaposi’s sarcoma herpes virus/human herpesvirus 8. IARC monograph on the evaluation of carcinogenic risks to humans 70. Lyon, France: IARC; p. 164–94.
معلومات مُعتمدة: CAPES coordenação de aperfeiçoamento de pessoal de nível superior; Finance Code 001 coordenação de aperfeiçoamento de pessoal de nível superior
فهرسة مساهمة: Keywords: Epstein-Barr virus; Oral squamous cell carcinoma; Periodontal pocket, Cancer; Periodontitis
تواريخ الأحداث: Date Created: 20211116 Date Completed: 20220308 Latest Revision: 20220308
رمز التحديث: 20221213
DOI: 10.1007/s00784-021-04258-z
PMID: 34783915
قاعدة البيانات: MEDLINE
الوصف
تدمد:1436-3771
DOI:10.1007/s00784-021-04258-z