دورية أكاديمية
أعرض في EDS

Precision Mapping of Amyloid-β Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits.

التفاصيل البيبلوغرافية
العنوان: Precision Mapping of Amyloid-β Binding Reveals Perisynaptic Localization and Spatially Restricted Plasticity Deficits.
المؤلفون: Actor-Engel HS; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Schwartz SL; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Crosby KC; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Sinnen BL; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Prikhodko O; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Ramsay HJ; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Bourne JN; Electron Microscopy Core, University of Colorado Anschutz Medical Campus, Aurora, CO 80045., Winborn CS; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Lucas A; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Smith KR; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Dell'Acqua ML; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045., Kennedy MJ; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045 matthew.kennedy@cuanschutz.edu.
المصدر: ENeuro [eNeuro] 2021 Dec 17; Vol. 8 (6). Date of Electronic Publication: 2021 Dec 17 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 101647362 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2373-2822 (Electronic) Linking ISSN: 23732822 NLM ISO Abbreviation: eNeuro Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Washington, DC] : Society for Neuroscience, [2014]-
مواضيع طبية MeSH: Alzheimer Disease* , Amyloid beta-Peptides*, Humans ; Neuronal Plasticity ; Neurons ; Synapses
مستخلص: Secreted amyloid-β (Aβ) peptide forms neurotoxic oligomeric assemblies thought to cause synaptic deficits associated with Alzheimer's disease (AD). Soluble Aβ oligomers (Aβo) directly bind to neurons with high affinity and block plasticity mechanisms related to learning and memory, trigger loss of excitatory synapses and eventually cause cell death. While Aβo toxicity has been intensely investigated, it remains unclear precisely where Aβo initially binds to the surface of neurons and whether sites of binding relate to synaptic deficits. Here, we used a combination of live cell, super-resolution and ultrastructural imaging techniques to investigate the kinetics, reversibility and nanoscale location of Aβo binding. Surprisingly, Aβo does not bind directly at the synaptic cleft as previously thought but, instead, forms distinct nanoscale clusters encircling the postsynaptic membrane with a significant fraction also binding presynaptic axon terminals. Synaptic plasticity deficits were observed at Aβo-bound synapses but not closely neighboring Aβo-free synapses. Thus, perisynaptic Aβo binding triggers spatially restricted signaling mechanisms to disrupt synaptic function. These data provide new insight into the earliest steps of Aβo pathology and lay the groundwork for future studies evaluating potential surface receptor(s) and local signaling mechanisms responsible for Aβo binding and synapse dysfunction.
(Copyright © 2021 Actor-Engel et al.)
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معلومات مُعتمدة: R01 MH119154 United States MH NIMH NIH HHS; R35 NS116879 United States NS NINDS NIH HHS; T32 NS099042 United States NS NINDS NIH HHS; R01 NS110383 United States NS NINDS NIH HHS; T32 GM007635 United States GM NIGMS NIH HHS; T32 AG000279 United States AG NIA NIH HHS; F32 MH123053 United States MH NIMH NIH HHS; R21 AG058005 United States AG NIA NIH HHS; F32 AG071073 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: LTP; amyloid-β; plasticity; postsynaptic density; super-resolution; synapse
المشرفين على المادة: 0 (Amyloid beta-Peptides)
تواريخ الأحداث: Date Created: 20211118 Date Completed: 20220202 Latest Revision: 20230621
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8687484
DOI: 10.1523/ENEURO.0416-21.2021
PMID: 34789478
قاعدة البيانات: MEDLINE
الوصف
تدمد:2373-2822
DOI:10.1523/ENEURO.0416-21.2021