دورية أكاديمية
أعرض في EDS

Slow Recovery from Inbreeding Depression Generated by the Complex Genetic Architecture of Segregating Deleterious Mutations.

التفاصيل البيبلوغرافية
العنوان: Slow Recovery from Inbreeding Depression Generated by the Complex Genetic Architecture of Segregating Deleterious Mutations.
المؤلفون: Adams PE; Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, USA., Crist AB; Department of Genomes and Genetics, Institut Pasteur, Paris, France., Young EM; Institute of Ecology and Evolution, University of Oregon, Eugene, OR, USA., Willis JH; Institute of Ecology and Evolution, University of Oregon, Eugene, OR, USA., Phillips PC; Institute of Ecology and Evolution, University of Oregon, Eugene, OR, USA., Fierst JL; Department of Biological Sciences, University of Alabama, Tuscaloosa, AL, USA.
المصدر: Molecular biology and evolution [Mol Biol Evol] 2022 Jan 07; Vol. 39 (1).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : New York, NY : Oxford University Press
Original Publication: [Chicago, Ill.] : University of Chicago Press, [c1983-
مواضيع طبية MeSH: Inbreeding Depression*, Alleles ; Animals ; Caenorhabditis elegans/genetics ; Inbreeding ; Male ; Mutation
مستخلص: The deleterious effects of inbreeding have been of extreme importance to evolutionary biology, but it has been difficult to characterize the complex interactions between genetic constraints and selection that lead to fitness loss and recovery after inbreeding. Haploid organisms and selfing organisms like the nematode Caenorhabditis elegans are capable of rapid recovery from the fixation of novel deleterious mutation; however, the potential for recovery and genomic consequences of inbreeding in diploid, outcrossing organisms are not well understood. We sought to answer two questions: 1) Can a diploid, outcrossing population recover from inbreeding via standing genetic variation and new mutation? and 2) How does allelic diversity change during recovery? We inbred C. remanei, an outcrossing relative of C. elegans, through brother-sister mating for 30 generations followed by recovery at large population size. Inbreeding reduced fitness but, surprisingly, recovery from inbreeding at large populations sizes generated only very moderate fitness recovery after 300 generations. We found that 65% of ancestral single nucleotide polymorphisms (SNPs) were fixed in the inbred population, far fewer than the theoretical expectation of ∼99%. Under recovery, 36 SNPs across 30 genes involved in alimentary, muscular, nervous, and reproductive systems changed reproducibly across replicates, indicating that strong selection for fitness recovery does exist. Our results indicate that recovery from inbreeding depression via standing genetic variation and mutation is likely to be constrained by the large number of segregating deleterious variants present in natural populations, limiting the capacity for recovery of small populations.
(© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)
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معلومات مُعتمدة: R01 GM102511 United States GM NIGMS NIH HHS; R35 GM131838 United States GM NIGMS NIH HHS
فهرسة مساهمة: Keywords: conservation genetics; genomics; inbreeding depression; nematode
تواريخ الأحداث: Date Created: 20211118 Date Completed: 20220331 Latest Revision: 20240822
رمز التحديث: 20240822
مُعرف محوري في PubMed: PMC8789292
DOI: 10.1093/molbev/msab330
PMID: 34791426
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-1719
DOI:10.1093/molbev/msab330