دورية أكاديمية
[Pharmacoeconomic and pharmacogenetic aspects of the implementation of a personalized approach in the treatment of cardiac patients].
| العنوان: | [Pharmacoeconomic and pharmacogenetic aspects of the implementation of a personalized approach in the treatment of cardiac patients]. |
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| المؤلفون: | Gruzdeva AA; Yaroslavl State Medical University of the Ministry of Health of Russia, 150000, Yaroslavl, Russia, gruzdeva-anna@mail.ru., Khokhlov AL; Yaroslavl State Medical University of the Ministry of Health of Russia, 150000, Yaroslavl, Russia., Ilyin MV; Yaroslavl State Medical University of the Ministry of Health of Russia, 150000, Yaroslavl, Russia., Oynotkinova OS; Research Institute for Healthcare Organization and Medical Management of Moscow Healthcare Department, 115088, Moscow, Russia.; M. V. Lomonosov Moscow State University, 119991, Moscow, Russia. |
| المصدر: | Problemy sotsial'noi gigieny, zdravookhraneniia i istorii meditsiny [Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med] 2021 Aug; Vol. 29 (Special Issue), pp. 1258-1263. |
| نوع المنشور: | Journal Article |
| اللغة: | Russian |
| بيانات الدورية: | Publisher: Akt︠s︡ionernoe obshchestvo “Shiko Country of Publication: Russia (Federation) NLM ID: 101270373 Publication Model: Print Cited Medium: Print ISSN: 0869-866X (Print) Linking ISSN: 0869866X NLM ISO Abbreviation: Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Moskva : Akt︠s︡ionernoe obshchestvo “Shiko” Original Publication: Moskva : Medit︠s︡ina, 1999- |
| مواضيع طبية MeSH: | Economics, Pharmaceutical* , Pharmacogenetics*, Costs and Cost Analysis ; Cytochrome P-450 CYP2D6/genetics ; Humans ; Polymorphism, Genetic |
| مستخلص: | Purpose: To investigate the possibilities of pharmacoeconomic and pharmacogenetic factors monitoring to assess the effectiveness of treatment of a cardiological profile patients as a part of the implementation of a personalized approach. Material and Methods: 200 patients with arterial hypertension and CHD were examined. Pharmacotherapy was analyzed. ABC/VEN and DDD analysis, pharmacoeconomic analysis were applied. Genetic analysis of the polymorphism of the genes CYP2D6*4 and CYP2D6*10 encoding the subfamily of the cytochrome isoenzyme Р-450 was carried out. An original monitoring method was used to assess the effect of pharmacoeconomic and pharmacogenetic factors on the performance of cardiac care. Results: When conducting a pharmacoeconomic analysis of cases of cardiac care, it was found that the costs of drug therapy are significant and take over 10% of the total costs. However, its effectiveness is insufficient in 58% of cases in inpatient and 37% in outpatient care. The analysis showed that there is an inverse mean correlation between gene polymorphism and clinical performance of cardiac care (r = -0.62) and a direct strong correlation between polypharmacy in pharmacotherapy, not accounting for interdrug interaction and clinical performance (r = 0.89). |
| فهرسة مساهمة: | Keywords: medical care; personalized therapy; rational pharmacotherapy |
| المشرفين على المادة: | EC 1.14.14.1 (Cytochrome P-450 CYP2D6) |
| تواريخ الأحداث: | Date Created: 20211118 Date Completed: 20211122 Latest Revision: 20211122 |
| رمز التحديث: | 20240628 |
| DOI: | 10.32687/0869-866X-2021-29-s2-1258-1263 |
| PMID: | 34792874 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0869-866X |
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| DOI: | 10.32687/0869-866X-2021-29-s2-1258-1263 |