دورية أكاديمية
The effect of probiotics supplementation in postoperative cancer patients: a prospective pilot study.
| العنوان: | The effect of probiotics supplementation in postoperative cancer patients: a prospective pilot study. |
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| المؤلفون: | Kwon H; Cancer Genomic Research Institute, Immunology Laboratory, Seoul Song Do Colorectal Hospital, Seoul, Korea., Chae SH; Cancer Genomic Research Institute, Immunology Laboratory, Seoul Song Do Colorectal Hospital, Seoul, Korea., Jung HJ; Cancer Genomic Research Institute, Immunology Laboratory, Seoul Song Do Colorectal Hospital, Seoul, Korea., Shin HM; Cancer Genomic Research Institute, Immunology Laboratory, Seoul Song Do Colorectal Hospital, Seoul, Korea., Ban OH; Ildong Bioscience, Pyeongtaek, Korea., Yang J; Ildong Bioscience, Pyeongtaek, Korea., Kim JH; Cancer Immune Clinic, Seoul Song Do Colorectal Hospital, Seoul, Korea.; Department of Surgery, Pelvic Floor Center, Seoul Song Do Colorectal Hospital, Seoul, Korea., Jeong JE; Cancer Immune Clinic, Seoul Song Do Colorectal Hospital, Seoul, Korea., Jeon HM; Cancer Genomic Research Institute, Immunology Laboratory, Seoul Song Do Colorectal Hospital, Seoul, Korea.; Cancer Immune Clinic, Seoul Song Do Colorectal Hospital, Seoul, Korea., Kang YW; Department of Surgery, Pelvic Floor Center, Seoul Song Do Colorectal Hospital, Seoul, Korea., Park CK; Department of Pathology, Seoul Song Do Colorectal Hospital, Seoul, Korea., Won DD; Department of Surgery, Pelvic Floor Center, Seoul Song Do Colorectal Hospital, Seoul, Korea., Lee JK; Cancer Immune Clinic, Seoul Song Do Colorectal Hospital, Seoul, Korea.; Department of Surgery, Pelvic Floor Center, Seoul Song Do Colorectal Hospital, Seoul, Korea. |
| المصدر: | Annals of surgical treatment and research [Ann Surg Treat Res] 2021 Nov; Vol. 101 (5), pp. 281-290. Date of Electronic Publication: 2021 Oct 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Surgical Society Country of Publication: Korea (South) NLM ID: 101622895 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2288-6575 (Print) Linking ISSN: 22886575 NLM ISO Abbreviation: Ann Surg Treat Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul : Korean Surgical Society, [2014]- |
| مستخلص: | Purpose: Microbiota manipulation through selected probiotics may be a promising tool to prevent cancer development as well as onset, to improve clinical efficacy for cancer treatments. The purpose of this study was to evaluate change in microbiota composition after-probiotics supplementation and assessed the efficacy of probiotics in improving quality of life (QOL) in postoperative cancer patients. Methods: Stool samples were collected from 30 cancer patients from February to October 2020 before (group I) and after (group II) 8 weeks of probiotics supplementation. We performed 16S ribosomal RNA gene sequencing to evaluate differences in gut microbiota between groups by comparing gut microbiota diversity, overall composition, and taxonomic signature abundance. The health-related QOL was evaluated through the EORTC Quality of life Questionnaire Core 30 questionnaire. Results: Statistically significant differences were noted in group II; increase of Shannon and Simpson index (P = 0.004 and P = 0.001), decrease of Bacteroidetes and Fusobacteria at the phylum level (P = 0.032 and P = 0.014, retrospectively), increased of beneficial bacteria such as Weissella (0.096% vs. 0.361%, P < 0.004), Lactococcus (0.023% vs. 0.16%, P < 0.001), and Catenibacterium (0.0% vs. 0.005%, P < 0.042) at the genus level. There was a significant improvement in sleep disturbance (P = 0.039) in group II. Conclusion: Gut microbiota in cancer patients can be manipulated by specific probiotic strains, result in an altered microbiota. Microbiota modulation by probiotics can be considered as part of a supplement that helps to increase gut microbiota diversity and improve QOL in cancer patients after surgery. Competing Interests: Conflict of Interest: No potential conflict of interest relevant to this article was reported. (Copyright © 2021, the Korean Surgical Society.) |
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| فهرسة مساهمة: | Keywords: Cancer patients; Gut microbiota; Postoperative; Probiotics; Quality of life |
| تواريخ الأحداث: | Date Created: 20211119 Latest Revision: 20220428 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8564079 |
| DOI: | 10.4174/astr.2021.101.5.281 |
| PMID: | 34796144 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2288-6575 |
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| DOI: | 10.4174/astr.2021.101.5.281 |