دورية أكاديمية
The red flags of ulnar neuropathy in leprosy.
| العنوان: | The red flags of ulnar neuropathy in leprosy. |
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| المؤلفون: | Jardim M; Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.; Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, Brazil.; Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Vital RT; Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, Brazil., Illarramendi X; Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Hacker M; Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Junqueira B; Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Pitta IJR; Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil.; Department of Neurology, Pedro Ernesto University Hospital/Rio de Janeiro State University, Rio de Janeiro, Brazil.; Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil., Pinheiro RO; Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil., Sarno EN; Oswaldo Cruz Institute, Fiocruz, Rio de Janeiro, Brazil. |
| المصدر: | PloS one [PLoS One] 2021 Nov 19; Vol. 16 (11), pp. e0259804. Date of Electronic Publication: 2021 Nov 19 (Print Publication: 2021). |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Leprosy/*diagnosis , Leprosy/*metabolism , Ulnar Neuropathies/*diagnosis, Adolescent ; Adult ; Aged ; Biomarkers ; Brazil/epidemiology ; Cross-Sectional Studies ; Data Management ; Databases, Factual ; Diagnosis, Differential ; Elbow Joint ; Female ; Humans ; Leprosy, Tuberculoid ; Male ; Middle Aged ; Neural Conduction ; Ulnar Nerve/metabolism ; Ulnar Neuropathies/physiopathology |
| مستخلص: | The diagnosis of pure neural leprosy is more challenging because patients share characteristics with other common pathologies, such as ulnar compression, which should be taken into consideration for differential diagnosis. In this study, we identify ulnar nerve conduction characteristics to aid in the differential diagnosis of ulnar neuropathy (UN) in leprosy and that of non-leprosy etiology. In addition, we include putative markers to better understand the inflammatory process that may occur in the nerve. Data were extracted from a database of people affected by leprosy (leprosy group) diagnosed with UN at leprosy diagnosis. A non-leprosy group of patients diagnosed with mechanical neuropathy (compressive, traumatic) was also included. Both groups were submitted to clinical, neurological, neurophysiological and immunological studies. Nerve enlargement and sensory impairment were significantly higher in leprosy patients than in patients with compressive UN. Bilateral impairment was significantly higher in the leprosy group than in the non-leprosy group. Leprosy reactions were associated to focal demyelinating lesions at the elbow and to temporal dispersion (TD). Clinical signs such as sensory impairment, nerve enlargement and bilateral ulnar nerve injury associated with eletrodiagnostic criteria such as demyelinating finds, specifically temporal dispersion, could be tools to help us decided on the best conduct in patients with elbow ulnar neuropathy and specifically decide if we should perform a nerve biopsy for diagnosis of pure neural leprosy. Competing Interests: No authors have competing interests. |
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| المشرفين على المادة: | 0 (Biomarkers) |
| تواريخ الأحداث: | Date Created: 20211119 Date Completed: 20220104 Latest Revision: 20220104 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8604365 |
| DOI: | 10.1371/journal.pone.0259804 |
| PMID: | 34797866 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0259804 |