دورية أكاديمية
أعرض في EDS

Promises and challenges of personalized medicine to guide ARDS therapy.

التفاصيل البيبلوغرافية
العنوان: Promises and challenges of personalized medicine to guide ARDS therapy.
المؤلفون: Wick KD; Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, HSE 760, San Francisco, CA, 94143, USA. katherine.wick@ucsf.edu., McAuley DF; Belfast Health and Social Care Trust, Royal Victoria Hospital and Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK., Levitt JE; Division of Pulmonary, Allergy, and Critical Care Medicine, Stanford University, Stanford, CA, USA., Beitler JR; Center for Acute Respiratory Failure and Division of Pulmonary, Allergy, and Critical Care Medicine, Columbia University, New York, NY, USA., Annane D; Department of Intensive Care, FHU SEPSIS, and RHU RECORDS, Hôpital Raymond Poincaré (APHP), Garches, France.; Laboratory of Infection & Inflammation, School of Medicine Simone Veil, INSERM, University Versailles Saint Quentin, University Paris Saclay, Garches, France., Riviello ED; Harvard Medical School and Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Calfee CS; Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, HSE 760, San Francisco, CA, 94143, USA.; Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA, USA., Matthay MA; Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, HSE 760, San Francisco, CA, 94143, USA.; Departments of Medicine and Anesthesia, University of California, San Francisco, San Francisco, CA, USA.
المصدر: Critical care (London, England) [Crit Care] 2021 Nov 23; Vol. 25 (1), pp. 404. Date of Electronic Publication: 2021 Nov 23.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 9801902 Publication Model: Electronic Cited Medium: Internet ISSN: 1466-609X (Electronic) Linking ISSN: 13648535 NLM ISO Abbreviation: Crit Care Subsets: MEDLINE
أسماء مطبوعة: Publication: London, UK : BioMed Central Ltd
Original Publication: London : Current Science Ltd, c1997-
مواضيع طبية MeSH: Precision Medicine*, Respiratory Distress Syndrome/*therapy, COVID-19/complications ; Clinical Trials as Topic ; Humans ; Respiratory Distress Syndrome/virology
مستخلص: Identifying new effective treatments for the acute respiratory distress syndrome (ARDS), including COVID-19 ARDS, remains a challenge. The field of ARDS investigation is moving increasingly toward innovative approaches such as the personalization of therapy to biological and clinical sub-phenotypes. Additionally, there is growing recognition of the importance of the global context to identify effective ARDS treatments. This review highlights emerging opportunities and continued challenges for personalizing therapy for ARDS, from identifying treatable traits to innovative clinical trial design and recognition of patient-level factors as the field of critical care investigation moves forward into the twenty-first century.
(© 2021. The Author(s).)
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معلومات مُعتمدة: K23-HL133489 United States NH NIH HHS; R21 HL145506 United States HL NHLBI NIH HHS; R35 HL140026 United States HL NHLBI NIH HHS; R21-HL145506 United States NH NIH HHS; K23 HL133489 United States HL NHLBI NIH HHS; MR/M009149/1 United Kingdom MRC_ Medical Research Council; UH3HL141722 United States NH NIH HHS; MC_G1002460 United Kingdom MRC_ Medical Research Council; T32 GM008440 United States GM NIGMS NIH HHS; 5T32GM8440-24 United States NH NIH HHS
فهرسة مساهمة: Keywords: Acute lung injury; Acute respiratory distress syndrome; COVID-19; Clinical trials; Personalized medicine
تواريخ الأحداث: Date Created: 20211124 Date Completed: 20211208 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC8609268
DOI: 10.1186/s13054-021-03822-z
PMID: 34814925
قاعدة البيانات: MEDLINE
الوصف
تدمد:1466-609X
DOI:10.1186/s13054-021-03822-z