دورية أكاديمية
أعرض في EDS

Adaptation, spread and transmission of SARS-CoV-2 in farmed minks and associated humans in the Netherlands.

التفاصيل البيبلوغرافية
العنوان: Adaptation, spread and transmission of SARS-CoV-2 in farmed minks and associated humans in the Netherlands.
المؤلفون: Lu L; Usher Institute, University of Edinburgh, Edinburgh, UK., Sikkema RS; Erasmus MC, Department of Viroscience, WHO Collaborating Centre, Rotterdam, the Netherlands., Velkers FC; Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Nieuwenhuijse DF; Erasmus MC, Department of Viroscience, WHO Collaborating Centre, Rotterdam, the Netherlands., Fischer EAJ; Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Meijer PA; Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Bouwmeester-Vincken N; Municipal Health Service GGD Limburg-Noord, Venlo, the Netherlands., Rietveld A; Municipal Health Service GGD Hart voor Brabant, Tilburg, the Netherlands., Wegdam-Blans MCA; Stichting PAMM, Veldhoven, the Netherlands., Tolsma P; Municipal Health Service GGD Brabant-Zuidoost, Eindhoven, the Netherlands., Koppelman M; Sanquin Blood Supply Foundation, Amsterdam, the Netherlands., Smit LAM; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, the Netherlands., Hakze-van der Honing RW; Wageningen Bioveterinary Research, Lelystad, the Netherlands., van der Poel WHM; Wageningen Bioveterinary Research, Lelystad, the Netherlands., van der Spek AN; Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, the Netherlands., Spierenburg MAH; Netherlands Food and Consumer Product Safety Authority (NVWA), Utrecht, the Netherlands., Molenaar RJ; GD Animal Health, Deventer, the Netherlands., Rond J; GD Animal Health, Deventer, the Netherlands., Augustijn M; GD Animal Health, Deventer, the Netherlands., Woolhouse M; Usher Institute, University of Edinburgh, Edinburgh, UK., Stegeman JA; Department Population Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands., Lycett S; Roslin Institute, University of Edinburgh, Edinburgh, UK., Oude Munnink BB; Erasmus MC, Department of Viroscience, WHO Collaborating Centre, Rotterdam, the Netherlands., Koopmans MPG; Erasmus MC, Department of Viroscience, WHO Collaborating Centre, Rotterdam, the Netherlands. m.koopmans@erasmusmc.nl.
المصدر: Nature communications [Nat Commun] 2021 Nov 23; Vol. 12 (1), pp. 6802. Date of Electronic Publication: 2021 Nov 23.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Evolution, Molecular* , Farms*, COVID-19/*epidemiology , COVID-19/*transmission , COVID-19/*virology , Mink/*virology , SARS-CoV-2/*genetics , SARS-CoV-2/*physiology, Amino Acid Sequence ; Animal Diseases/epidemiology ; Animal Diseases/transmission ; Animal Diseases/virology ; Animals ; Bayes Theorem ; Disease Outbreaks ; Humans ; Netherlands/epidemiology ; Phylogeny ; SARS-CoV-2/isolation & purification ; Sequence Analysis, Protein ; Spike Glycoprotein, Coronavirus/classification ; Spike Glycoprotein, Coronavirus/genetics
مستخلص: In the first wave of the COVID-19 pandemic (April 2020), SARS-CoV-2 was detected in farmed minks and genomic sequencing was performed on mink farms and farm personnel. Here, we describe the outbreak and use sequence data with Bayesian phylodynamic methods to explore SARS-CoV-2 transmission in minks and humans on farms. High number of farm infections (68/126) in minks and farm workers (>50% of farms) were detected, with limited community spread. Three of five initial introductions of SARS-CoV-2 led to subsequent spread between mink farms until November 2020. Viruses belonging to the largest cluster acquired an amino acid substitution in the receptor binding domain of the Spike protein (position 486), evolved faster and spread longer and more widely. Movement of people and distance between farms were statistically significant predictors of virus dispersal between farms. Our study provides novel insights into SARS-CoV-2 transmission between mink farms and highlights the importance of combining genetic information with epidemiological information when investigating outbreaks at the animal-human interface.
(© 2021. The Author(s).)
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معلومات مُعتمدة: 10150062010005 ZonMw (Netherlands Organisation for Health Research and Development); BBS/E/D/20002173 RCUK | Biotechnology and Biological Sciences Research Council (BBSRC)
المشرفين على المادة: 0 (Spike Glycoprotein, Coronavirus)
0 (spike protein, SARS-CoV-2)
تواريخ الأحداث: Date Created: 20211124 Date Completed: 20211207 Latest Revision: 20211214
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8611045
DOI: 10.1038/s41467-021-27096-9
PMID: 34815406
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-021-27096-9