#COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol.
| العنوان: | #COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol. |
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| المؤلفون: | Dommer A; UC San Diego., Casalino L; UC San Diego., Kearns F; UC San Diego., Rosenfeld M; UC San Diego., Wauer N; UC San Diego., Ahn SH; UC San Diego., Russo J; Oregon Health & Science University., Oliveira S; University of Bristol., Morris C; UC San Diego., Bogetti A; University of Pittsburgh., Trifan A; Argonne National Laboratory.; University of Illinois at Urbana-Champaign., Brace A; Argonne National Laboratory.; University of Chicago., Sztain T; UC San Diego.; Freie Universität Berlin., Clyde A; Argonne National Laboratory.; University of Chicago., Ma H; Argonne National Laboratory., Chennubhotla C; University of Pittsburgh., Lee H; Brookhaven National Lab & Rutgers University., Turilli M; Brookhaven National Lab & Rutgers University., Khalid S; University of Oxford., Tamayo-Mendoza T; Entos, Inc., Welborn M; Entos, Inc., Christensen A; Entos, Inc., Smith DGA; Entos, Inc., Qiao Z; California Institute of Technology., Sirumalla SK; Entos, Inc., O'Connor M; Entos, Inc., Manby F; Entos, Inc., Anandkumar A; California Institute of Technology.; NVIDIA Corporation., Hardy D; University of Illinois at Urbana-Champaign., Phillips J; University of Illinois at Urbana-Champaign., Stern A; NVIDIA Corporation., Romero J; NVIDIA Corporation., Clark D; NVIDIA Corporation., Dorrell M; Pittsburgh Supercomputing Center., Maiden T; Pittsburgh Supercomputing Center., Huang L; Texas Advanced Computing Center., McCalpin J; Texas Advanced Computing Center., Woods C; University of Bristol., Gray A; NVIDIA Corporation., Williams M; University of Bristol., Barker B; Oracle for Research., Rajapaksha H; Oracle for Research., Pitts R; Oracle for Research., Gibbs T; NVIDIA Corporation., Stone J; University of Illinois at Urbana-Champaign., Zuckerman D; Oregon Health & Science University., Mulholland A; University of Bristol., Miller T 3rd; Entos, Inc.; California Institute of Technology., Jha S; Brookhaven National Lab & Rutgers University., Ramanathan A; Argonne National Laboratory., Chong L; University of Pittsburgh., Amaro R; UC San Diego. |
| المصدر: | BioRxiv : the preprint server for biology [bioRxiv] 2021 Nov 15. Date of Electronic Publication: 2021 Nov 15. |
| نوع المنشور: | Preprint |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: | We seek to completely revise current models of airborne transmission of respiratory viruses by providing never-before-seen atomic-level views of the SARS-CoV-2 virus within a respiratory aerosol. Our work dramatically extends the capabilities of multiscale computational microscopy to address the significant gaps that exist in current experimental methods, which are limited in their ability to interrogate aerosols at the atomic/molecular level and thus ob-scure our understanding of airborne transmission. We demonstrate how our integrated data-driven platform provides a new way of exploring the composition, structure, and dynamics of aerosols and aerosolized viruses, while driving simulation method development along several important axes. We present a series of initial scientific discoveries for the SARS-CoV-2 Delta variant, noting that the full scientific impact of this work has yet to be realized. Acm Reference Format: Abigail Dommer 1† , Lorenzo Casalino 1† , Fiona Kearns 1† , Mia Rosenfeld 1 , Nicholas Wauer 1 , Surl-Hee Ahn 1 , John Russo, 2 Sofia Oliveira 3 , Clare Morris 1 , AnthonyBogetti 4 , AndaTrifan 5,6 , Alexander Brace 5,7 , TerraSztain 1,8 , Austin Clyde 5,7 , Heng Ma 5 , Chakra Chennubhotla 4 , Hyungro Lee 9 , Matteo Turilli 9 , Syma Khalid 10 , Teresa Tamayo-Mendoza 11 , Matthew Welborn 11 , Anders Christensen 11 , Daniel G. A. Smith 11 , Zhuoran Qiao 12 , Sai Krishna Sirumalla 11 , Michael O'Connor 11 , Frederick Manby 11 , Anima Anandkumar 12,13 , David Hardy 6 , James Phillips 6 , Abraham Stern 13 , Josh Romero 13 , David Clark 13 , Mitchell Dorrell 14 , Tom Maiden 14 , Lei Huang 15 , John McCalpin 15 , Christo- pherWoods 3 , Alan Gray 13 , MattWilliams 3 , Bryan Barker 16 , HarindaRajapaksha 16 , Richard Pitts 16 , Tom Gibbs 13 , John Stone 6 , Daniel Zuckerman 2 *, Adrian Mulholland 3 *, Thomas MillerIII 11,12 *, ShantenuJha 9 *, Arvind Ramanathan 5 *, Lillian Chong 4 *, Rommie Amaro 1 *. 2021. #COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy ofDeltaSARS-CoV-2 in a Respiratory Aerosol. In Supercomputing '21: International Conference for High Perfor-mance Computing, Networking, Storage, and Analysis . ACM, New York, NY, USA, 14 pages. https://doi.org/finalDOI. |
| التعليقات: | Update in: Int J High Perform Comput Appl. 2023 Jan;37(1):28-44. (PMID: 36647365) |
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| معلومات مُعتمدة: | P41 GM104601 United States GM NIGMS NIH HHS; R01 GM115805 United States GM NIGMS NIH HHS; R01 GM132826 United States GM NIGMS NIH HHS; T32 EB009380 United States EB NIBIB NIH HHS |
| تواريخ الأحداث: | Date Created: 20211124 Latest Revision: 20240407 |
| رمز التحديث: | 20240407 |
| مُعرف محوري في PubMed: | PMC8609898 |
| DOI: | 10.1101/2021.11.12.468428 |
| PMID: | 34816263 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1101/2021.11.12.468428 |
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