دورية أكاديمية
Parahippocampal latrophilin-2 (ADGRL2) expression controls topographical presubiculum to entorhinal cortex circuit connectivity.
| العنوان: | Parahippocampal latrophilin-2 (ADGRL2) expression controls topographical presubiculum to entorhinal cortex circuit connectivity. |
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| المؤلفون: | Donohue JD; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA; Neuroscience Graduate Program, University of California-Riverside, Riverside, CA 92521, USA., Amidon RF; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA., Murphy TR; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA., Wong AJ; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA., Liu ED; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA., Saab L; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA., King AJ; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA; Neuroscience Graduate Program, University of California-Riverside, Riverside, CA 92521, USA., Pae H; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA; Neuroscience Graduate Program, University of California-Riverside, Riverside, CA 92521, USA., Ajayi MT; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA., Anderson GR; Department of Molecular, Cell, and Systems Biology, University of California-Riverside, Riverside, CA 92521, USA. Electronic address: garret.anderson@ucr.edu. |
| المصدر: | Cell reports [Cell Rep] 2021 Nov 23; Vol. 37 (8), pp. 110031. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Cambridge, MA] : Cell Press, c 2012- |
| مواضيع طبية MeSH: | Entorhinal Cortex/*physiology , Receptors, Peptide/*genetics, Animals ; Entorhinal Cortex/metabolism ; Female ; Gene Expression/genetics ; Gene Expression Regulation/genetics ; Hippocampus/physiology ; Male ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Neural Pathways/cytology ; Neurons/physiology ; Parahippocampal Gyrus/metabolism ; Receptors, Peptide/metabolism |
| مستخلص: | Brain circuits are comprised of distinct interconnected neurons that are assembled by synaptic recognition molecules presented by defined pre- and post-synaptic neurons. This cell-cell recognition process is mediated by varying cellular adhesion molecules, including the latrophilin family of adhesion G-protein-coupled receptors. Focusing on parahippocampal circuitry, we find that latrophilin-2 (Lphn2; gene symbol ADGRL2) is specifically enriched in interconnected subregions of the medial entorhinal cortex (MEC), presubiculum (PrS), and parasubiculum (PaS). Retrograde viral tracing from the Lphn2-enriched region of the MEC reveals unique topographical patterning of inputs arising from the PrS and PaS that mirrors Lphn2 expression. Using a Lphn2 conditional knockout mouse model, we find that deletion of MEC Lphn2 expression selectively impairs retrograde viral labeling of inputs arising from the ipsilateral PrS. Combined with analysis of Lphn2 expression within the MEC, this study reveals Lphn2 to be selectively expressed by defined cell types and essential for MEC-PrS circuit connectivity. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: adhesion-GPCRs; entorhinal cortex; neural circuit connectivity; parasubiculum; presubiculum; synaptic recognition |
| المشرفين على المادة: | 0 (Receptors, Peptide) 0 (latrophilin-2, mouse) |
| تواريخ الأحداث: | Date Created: 20211124 Date Completed: 20220214 Latest Revision: 20220214 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.celrep.2021.110031 |
| PMID: | 34818557 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2211-1247 |
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| DOI: | 10.1016/j.celrep.2021.110031 |