دورية أكاديمية
أعرض في EDS

Epigenetic State Changes Underlie Metabolic Switch in Mouse Post-Infarction Border Zone Cardiomyocytes.

التفاصيل البيبلوغرافية
العنوان: Epigenetic State Changes Underlie Metabolic Switch in Mouse Post-Infarction Border Zone Cardiomyocytes.
المؤلفون: Günthel M; Department of Medical Biology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam University Medical Centers, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands., van Duijvenboden K; Department of Medical Biology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam University Medical Centers, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands., de Bakker DEM; Hubrecht Institute-KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.; Leibniz Institute on Aging-Fritz Lipmann Institute, 07745 Jena, Germany., Hooijkaas IB; Department of Medical Biology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam University Medical Centers, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands., Bakkers J; Hubrecht Institute-KNAW, University Medical Center Utrecht, 3584 CT Utrecht, The Netherlands.; Department of Pediatric Cardiology, Division of Pediatrics, University Medical Center Utrecht, 3584 CX Utrecht, The Netherlands., Barnett P; Department of Medical Biology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam University Medical Centers, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands., Christoffels VM; Department of Medical Biology, Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam University Medical Centers, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands.
المصدر: Journal of cardiovascular development and disease [J Cardiovasc Dev Dis] 2021 Oct 22; Vol. 8 (11). Date of Electronic Publication: 2021 Oct 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101651414 Publication Model: Electronic Cited Medium: Internet ISSN: 2308-3425 (Electronic) Linking ISSN: 23083425 NLM ISO Abbreviation: J Cardiovasc Dev Dis Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG
مستخلص: Myocardial infarction causes ventricular muscle loss and formation of scar tissue. The surviving myocardium in the border zone, located adjacent to the infarct, undergoes profound changes in function, structure and composition. How and to what extent these changes of border zone cardiomyocytes are regulated epigenetically is not fully understood. Here, we obtained transcriptomes of PCM-1-sorted mouse cardiomyocyte nuclei of healthy left ventricle and 7 days post myocardial infarction border zone tissue. We validated previously observed downregulation of genes involved in fatty acid metabolism, oxidative phosphorylation and mitochondrial function in border zone-derived cardiomyocytes, and observed a modest induction of genes involved in glycolysis, including Slc2a1 (Glut1) and Pfkp . To gain insight into the underlying epigenetic regulatory mechanisms, we performed H3K27ac profiling of healthy and border zone cardiomyocyte nuclei. We confirmed the switch from Mef2- to AP-1 chromatin association in border zone cardiomyocytes, and observed, in addition, an enrichment of PPAR/RXR binding motifs in the sites with reduced H3K27ac signal. We detected downregulation and accompanying epigenetic state changes at several key PPAR target genes including Ppargc1a (PGC-1α), Cpt2 , Ech1 , Fabpc3 and Vldrl in border zone cardiomyocytes. These data indicate that changes in epigenetic state and gene regulation underlie the maintained metabolic switch in border zone cardiomyocytes.
References: Bioinformatics. 2009 Jul 15;25(14):1754-60. (PMID: 19451168)
Nat Commun. 2021 Mar 12;12(1):1648. (PMID: 33712605)
Circ Res. 2014 Jul 18;115(3):354-63. (PMID: 24833660)
Circ Cardiovasc Genet. 2017 Jun;10(3):. (PMID: 28611032)
Int J Cardiol. 1997 Aug 8;60(3):273-9. (PMID: 9261638)
Mol Microbiol. 2012 Dec;86(6):1345-63. (PMID: 23043393)
Elife. 2019 Dec 23;8:. (PMID: 31868166)
Genes Dev. 2008 Jul 15;22(14):1948-61. (PMID: 18628400)
Biochem J. 2016 May 1;473(9):1191-202. (PMID: 26936967)
Cell Mol Life Sci. 2021 Jun;78(12):5107-5122. (PMID: 33950316)
Nature. 2017 Oct 12;550(7675):260-264. (PMID: 28976966)
J Cardiovasc Dev Dis. 2021 Apr 07;8(4):. (PMID: 33917189)
Circulation. 2017 Aug 29;136(9):834-848. (PMID: 28642276)
Cardiovasc Res. 1997 Feb;33(2):243-57. (PMID: 9074687)
Elife. 2017 Jan 16;6:. (PMID: 28079019)
Int J Mol Sci. 2021 Jun 15;22(12):. (PMID: 34203800)
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21931-6. (PMID: 21106759)
Mol Cell Biochem. 2007 Aug;302(1-2):225-32. (PMID: 17387581)
Cell Rep. 2020 Mar 3;30(9):3079-3091.e5. (PMID: 32130908)
Circulation. 2016 Mar 15;133(11):1081-92. (PMID: 26841808)
Nat Protoc. 2009;4(1):44-57. (PMID: 19131956)
Circulation. 2007 May 15;115(19):2540-8. (PMID: 17502589)
Science. 2018 Dec 21;362(6421):. (PMID: 30409805)
Circulation. 2016 Jan 26;133(4):e38-360. (PMID: 26673558)
Cell Mol Biol Lett. 2019 Dec 02;24:63. (PMID: 31827539)
Genome Biol. 2014;15(12):550. (PMID: 25516281)
Commun Biol. 2021 Jan 29;4(1):146. (PMID: 33514846)
Curr Protoc Mol Biol. 2019 Apr;126(1):e85. (PMID: 30688406)
Mol Cell Endocrinol. 2018 Aug 15;471:51-62. (PMID: 28778663)
Nat Commun. 2021 Jan 29;12(1):681. (PMID: 33514719)
Circ Res. 1999 Nov 26;85(11):1046-55. (PMID: 10571536)
J Cell Mol Med. 2020 Jun;24(11):5937-5954. (PMID: 32384583)
EMBO Rep. 2020 Aug 5;21(8):e49752. (PMID: 32648304)
J Lipid Res. 2014 Aug;55(8):1622-33. (PMID: 24899625)
Circulation. 2019 Sep 9;140(10):864-879. (PMID: 31259610)
PPAR Res. 2015;2015:271983. (PMID: 26587015)
Trends Cardiovasc Med. 2000 Aug;10(6):238-45. (PMID: 11282301)
Circulation. 2018 Jul 10;138(2):166-180. (PMID: 29386203)
Circulation. 2017 Oct 10;136(15):1396-1409. (PMID: 28724751)
Circ Res. 2005 Jan 7;96(1):110-8. (PMID: 15576649)
Oncotarget. 2017 May 17;8(37):60809-60825. (PMID: 28977827)
Circulation. 2020 Apr 14;141(15):1249-1265. (PMID: 32078387)
Int J Legal Med. 2018 Mar;132(2):425-438. (PMID: 29362873)
Nucleic Acids Res. 2009 Jan;37(1):1-13. (PMID: 19033363)
Bioinformatics. 2013 Jan 1;29(1):15-21. (PMID: 23104886)
J Histochem Cytochem. 2001 Jan;49(1):1-8. (PMID: 11118473)
Elife. 2019 Mar 26;8:. (PMID: 30912746)
Circ Heart Fail. 2015 Nov;8(6):1123-32. (PMID: 26443578)
Circ Res. 2019 Sep 13;125(7):707-719. (PMID: 31412728)
Biochem Biophys Res Commun. 2007 Dec 21;364(3):567-72. (PMID: 17963722)
Int J Mol Sci. 2020 Dec 11;21(24):. (PMID: 33322384)
Curr Cardiol Rep. 2018 Jun 14;20(8):63. (PMID: 29904823)
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W187-91. (PMID: 24799436)
Gen Physiol Biophys. 2011 Dec;30(4):329-41. (PMID: 22131314)
Int J Mol Sci. 2021 Jul 21;22(15):. (PMID: 34360540)
Eur Heart J. 2002 Jun;23(11):849-57. (PMID: 12042006)
Genom Data. 2015 Sep 01;6:120-2. (PMID: 26697350)
Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H584-H596. (PMID: 28646024)
Cell Death Discov. 2019 Mar 4;5:73. (PMID: 30854232)
Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H971-H984. (PMID: 30735072)
Bioinformatics. 2010 Mar 15;26(6):841-2. (PMID: 20110278)
EMBO Rep. 2016 Dec;17(12):1721-1730. (PMID: 27856534)
Nat Med. 2015 Apr;21(4):353-62. (PMID: 25751817)
Exp Cell Res. 2011 Jan 15;317(2):188-94. (PMID: 20828558)
Science. 2021 Apr 9;372(6538):201-205. (PMID: 33833125)
Circ Res. 2020 Jun 5;126(12):1760-1778. (PMID: 32312172)
معلومات مُعتمدة: COBRA3 Hartstichting; OUTREACH Hartstichting
فهرسة مساهمة: Keywords: H3K27ac; border zone; epigenetics; myocardial infarction; nuclear RNA-sequencing; transcriptome
تواريخ الأحداث: Date Created: 20211125 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC8620718
DOI: 10.3390/jcdd8110134
PMID: 34821687
قاعدة البيانات: MEDLINE
الوصف
تدمد:2308-3425
DOI:10.3390/jcdd8110134