دورية أكاديمية
أعرض في EDS

Wound Healing Metabolites from Peters' Elephant-Nose Fish Oil: An In Vivo Investigation Supported by In Vitro and In Silico Studies.

التفاصيل البيبلوغرافية
العنوان: Wound Healing Metabolites from Peters' Elephant-Nose Fish Oil: An In Vivo Investigation Supported by In Vitro and In Silico Studies.
المؤلفون: Alsenani F; Department of Pharmacognosy, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Ashour AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia., Alzubaidi MA; Department of Biological Sciences, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia., Azmy AF; Department of Microbiology, Faculty of Pharmacy, Beni-Suef University, Beni Suef 62514, Egypt., Hetta MH; Department of Pharmacognosy, Faculty of Pharmacy, Fayoum University, Fayoum 63514, Egypt., Abu-Baih DH; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt., Elrehany MA; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt., Zayed A; Department of Pharmacognosy, College of Pharmacy, Medical Campus, Tanta University, Elguish Street, Tanta 31527, Egypt.; Institute of Bioprocess Engineering, Technical University of Kaiserslautern, Gottlieb-Daimler-Str. 49, 67663 Kaiserslautern, Germany., Sayed AM; Department of Pharmacognosy, Faculty of Pharmacy, Nahda University, Beni Suef 62513, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Al-Maaqal University, Basra 61014, Iraq., Abdelmohsen UR; Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt., Elmaidomy AH; Department of Pharmacognosy, Faculty of Pharmacy, Beni-Suef University, Beni Suef 62514, Egypt.
المصدر: Marine drugs [Mar Drugs] 2021 Oct 26; Vol. 19 (11). Date of Electronic Publication: 2021 Oct 26.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2003]-
مواضيع طبية MeSH: Fishes*, Antioxidants/*pharmacology , Fish Oils/*pharmacology , Wound Healing/*drug effects, Animals ; Antioxidants/chemistry ; Antioxidants/metabolism ; Aquatic Organisms ; Fish Oils/chemistry ; Fish Oils/metabolism ; Gas Chromatography-Mass Spectrometry ; Male ; Models, Animal ; Molecular Docking Simulation ; Rabbits
مستخلص: Gnathonemus petersii (F. Mormyridae) commonly known as Peters' elephant-nose fish is a freshwater elephant fish native to West and Central African rivers. The present research aimed at metabolic profiling of its derived crude oil via GC-MS analysis. In addition, wound healing aptitude in adult male New Zealand Dutch strain albino rabbits along with isolated bioactive compounds in comparison with a commercial product (Mebo ® ). The molecular mechanism was studied through a number of in vitro investigations, i.e., radical scavenging and inhibition of COX enzymes, in addition to in silico molecular docking study. The results revealed a total of 35 identified (71.11%) compounds in the fish oil, belonging to fatty acids (59.57%), sterols (6.11%), and alkanes (5.43%). Phytochemical investigation of the crude oil afforded isolation of six compounds 1-6 . Moreover, the crude oil showed significant in vitro hydrogen peroxide and superoxide radical scavenging activities. Furthermore, the crude oil along with one of its major components (compound 4 ) exhibited selective inhibitory activity towards COX-2 with IC 50 values of 15.27 and 2.41 µM, respectively. Topical application of the crude oil on excision wounds showed a significant ( p < 0.05) increase in the wound healing rate in comparison to the untreated and Mebo ® -treated groups, where fish oil increased the TGF-β1 expression, down-regulated TNF- α , and IL-1β. Accordingly, Peters' elephant-nose fish oil may be a potential alternative medication helping wound healing owing to its antioxidant and anti-inflammatory activities.
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فهرسة مساهمة: Keywords: COX; GC-MS; Inflammatory mediators; Peters’ elephant-nose fish; fatty acids; molecular dynamic simulation; molecular modeling; wound healing
المشرفين على المادة: 0 (Antioxidants)
0 (Fish Oils)
تواريخ الأحداث: Date Created: 20211125 Date Completed: 20220210 Latest Revision: 20220210
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8625051
DOI: 10.3390/md19110605
PMID: 34822477
قاعدة البيانات: MEDLINE
الوصف
تدمد:1660-3397
DOI:10.3390/md19110605