دورية أكاديمية
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Phenothiazinium dyes for photodynamic treatment present lower environmental risk compared to a formulation of trifloxystrobin and tebuconazole.

التفاصيل البيبلوغرافية
العنوان: Phenothiazinium dyes for photodynamic treatment present lower environmental risk compared to a formulation of trifloxystrobin and tebuconazole.
المؤلفون: Andrade GC; University of São Paulo (USP), School of Pharmaceutical Sciences of Ribeirão Preto, 14040-903 Ribeirão Preto, SP, Brazil., Brancini GTP; University of São Paulo (USP), School of Pharmaceutical Sciences of Ribeirão Preto, 14040-903 Ribeirão Preto, SP, Brazil., Abe FR; University of São Paulo (USP), School of Pharmaceutical Sciences of Ribeirão Preto, 14040-903 Ribeirão Preto, SP, Brazil., de Oliveira DP; University of São Paulo (USP), School of Pharmaceutical Sciences of Ribeirão Preto, 14040-903 Ribeirão Preto, SP, Brazil; National Institute for Alternative Technologies of Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), São Paulo State University (UNESP), Institute of Chemistry, 14800-060 Araraquara, SP, Brazil., Nicolella HD; University of Franca, Laboratory of Mutagenesis, 14404-600 Franca, SP, Brazil., Tavares DC; University of Franca, Laboratory of Mutagenesis, 14404-600 Franca, SP, Brazil., Micas AFD; Companhia Ambiental do Estado de São Paulo (CETESB), Divisão de Laboratório de Ribeirão Preto, 14096-350 Ribeirão Preto, SP, Brazil., Savazzi EA; Companhia Ambiental do Estado de São Paulo (CETESB), Divisão de Laboratório de Ribeirão Preto, 14096-350 Ribeirão Preto, SP, Brazil., Silva-Junior GJ; Fund for Citrus Protection, Fundecitrus, 14807-040 Araraquara, SP, Brazil., Wainwright M; School of Pharmacy & Biomolecular Sciences, Liverpool John Moores University, L3 3AF Liverpool, UK., Braga GÚL; University of São Paulo (USP), School of Pharmaceutical Sciences of Ribeirão Preto, 14040-903 Ribeirão Preto, SP, Brazil. Electronic address: gbraga@fcfrp.usp.br.
المصدر: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2022 Jan; Vol. 226, pp. 112365. Date of Electronic Publication: 2021 Nov 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B
أسماء مطبوعة: Original Publication: Lausanne : Elsevier Sequoia, 1987-
مواضيع طبية MeSH: Strobilurins*/pharmacology , Strobilurins*/chemistry , Photosensitizing Agents*/pharmacology , Photosensitizing Agents*/chemistry , Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/toxicity , Methacrylates*/chemistry , Methacrylates*/toxicity , Methacrylates*/pharmacology, Animals ; Phenothiazines/chemistry ; Phenothiazines/pharmacology ; Phenothiazines/toxicity ; Photochemotherapy ; Acetates/pharmacology ; Acetates/chemistry ; Methylene Blue/chemistry ; Methylene Blue/pharmacology ; Antifungal Agents/pharmacology ; Antifungal Agents/chemistry ; Imines/chemistry ; Imines/toxicity ; Zebrafish ; Daphnia/drug effects ; Coloring Agents/chemistry
مستخلص: The widespread use of conventional chemical antifungal agents has led to worldwide concern regarding the selection of resistant isolates. In this scenario, antimicrobial photodynamic treatment (APDT) has emerged as a promising alternative to overcome this issue. The technique is based on the use of a photosensitizer (PS) and light in the presence of molecular oxygen. Under these conditions, the PS generates reactive oxygen species which damage the biomolecules of the target organism leading to cell death. The great potential of APDT against plant-pathogenic fungi has already been reported both in vitro and in planta, indicating this control measure has the potential to be widely used in crop plants. However, there is a lack of studies on environmental risk with ecotoxicological assessment of PSs used in APDT. Therefore, this study aimed to evaluate the environmental toxicity of four phenothiazinium PSs: i) methylene blue (MB), ii) new methylene blue N (NMBN), iii) toluidine blue O (TBO), and iv) dimethylmethylene blue (DMMB) and also of the commercial antifungal NATIVO®, a mixture of trifloxystrobin and tebuconazole. The experiments were performed with Daphnia similis neonates and zebrafish embryos. Our results showed that the PSs tested had different levels of toxicity, with MB being the less toxic and DMMB being the most. Nonetheless, the environmental toxicity of these PSs were lower when compared to that of NATIVO®. Furthermore, estimates of bioconcentration and of biotransformation half-life indicated that the PSs are environmentally safer than NATIVO®. Taken together, our results show that the toxicity associated with phenothiazinium PSs would not constitute an impediment to their use in APDT. Therefore, APDT is a promising approach to control plant-pathogenic fungi with reduced risk for selecting resistant isolates and lower environmental impacts when compared to commonly used antifungal agents.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Ecotoxicity; Fungicides; Photodynamic treatment; Photosensitizers; Pollutants
المشرفين على المادة: 401ATW8TRW (tebuconazole)
0 (Strobilurins)
F625Z36B2D (trifloxystrobin)
0 (Photosensitizing Agents)
0 (Triazoles)
0 (Methacrylates)
0 (Phenothiazines)
0 (Acetates)
T42P99266K (Methylene Blue)
0 (Antifungal Agents)
0 (Imines)
0 (Coloring Agents)
تواريخ الأحداث: Date Created: 20211125 Date Completed: 20240725 Latest Revision: 20240725
رمز التحديث: 20240726
DOI: 10.1016/j.jphotobiol.2021.112365
PMID: 34823208
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2682
DOI:10.1016/j.jphotobiol.2021.112365