دورية أكاديمية
أعرض في EDS

Physical therapy exerts sub-additive and suppressive effects on intracerebral neural stem cell implantation in a rat model of stroke.

التفاصيل البيبلوغرافية
العنوان: Physical therapy exerts sub-additive and suppressive effects on intracerebral neural stem cell implantation in a rat model of stroke.
المؤلفون: Ghuman H; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Perry N; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Grice L; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Gerwig M; Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Moorhead J Jr; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Nitzsche F; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Poplawsky AJ; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Ambrosio F; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Modo M; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
المصدر: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2022 May; Vol. 42 (5), pp. 826-843. Date of Electronic Publication: 2021 Nov 26.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 8112566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-7016 (Electronic) Linking ISSN: 0271678X NLM ISO Abbreviation: J Cereb Blood Flow Metab Subsets: MEDLINE
أسماء مطبوعة: Publication: 2016- : Thousand Oaks, CA : SAGE Publications
Original Publication: New York : Raven Press, c1981-
مواضيع طبية MeSH: Neural Stem Cells* , Stroke*, Animals ; Cell Line ; Cell- and Tissue-Based Therapy ; Humans ; Physical Therapy Modalities ; Rats ; Stem Cell Transplantation
مستخلص: Intracerebral cell therapy (CT) is emerging as a new therapeutic paradigm for stroke. However, the impact of physical therapy (PT) on implanted cells and their ability to promote recovery remains poorly understood. To address this translational issue, a clinical-grade neural stem cell (NSC) line was implanted into peri-infarct tissue using MRI-defined injection sites, two weeks after stroke. PT in the form of aerobic exercise (AE) was administered 5 × per week post-implantation using a paradigm commonly applied in patients with stroke. A combined AE and CT exerted sub-additive therapeutic effects on sensory neglect, whereas AE suppressed CT effects on motor integration and grip strength. Behavioral testing emerged as a potentially major component for task integration. It is expected that this study will guide and inform the incorporation of PT in the design of clinical trials evaluating intraparenchymal NSCs implantation for stroke.
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معلومات مُعتمدة: P2C HD086843 United States HD NICHD NIH HHS; R01 EB003324 United States EB NIBIB NIH HHS; R56 AG052978 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: Physical therapy; aerobic exercise; cell therapy; neural stem cell; neurorehabilitation; stroke
تواريخ الأحداث: Date Created: 20211126 Date Completed: 20220413 Latest Revision: 20221127
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC9254031
DOI: 10.1177/0271678X211062955
PMID: 34826373
قاعدة البيانات: MEDLINE
الوصف
تدمد:1559-7016
DOI:10.1177/0271678X211062955