دورية أكاديمية
A Simple Preoperative Blood Count to Stratify Prognosis in Isocitrate Dehydrogenase-Wildtype Glioblastoma Patients Treated with Radiotherapy plus Concomitant and Adjuvant Temozolomide.
العنوان: | A Simple Preoperative Blood Count to Stratify Prognosis in Isocitrate Dehydrogenase-Wildtype Glioblastoma Patients Treated with Radiotherapy plus Concomitant and Adjuvant Temozolomide. |
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المؤلفون: | Clavreul A; Université d'Angers, CHU d'Angers, CRCINA, F-49000 Angers, France.; Département de Neurochirurgie, CHU Angers, F-49933 Angers, France., Lemée JM; Université d'Angers, CHU d'Angers, CRCINA, F-49000 Angers, France.; Département de Neurochirurgie, CHU Angers, F-49933 Angers, France., Soulard G; Département de Neurochirurgie, CHU Angers, F-49933 Angers, France., Rousseau A; Université d'Angers, CHU d'Angers, CRCINA, F-49000 Angers, France.; Département de Pathologie Cellulaire et Tissulaire, CHU Angers, F-49933 Angers, France., Menei P; Université d'Angers, CHU d'Angers, CRCINA, F-49000 Angers, France.; Département de Neurochirurgie, CHU Angers, F-49933 Angers, France. |
المصدر: | Cancers [Cancers (Basel)] 2021 Nov 18; Vol. 13 (22). Date of Electronic Publication: 2021 Nov 18. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
مستخلص: | Purpose: The survival times of glioblastoma (GB) patients after the standard therapy including safe maximal resection followed by radiotherapy plus concomitant and adjuvant temozolomide are heterogeneous. In order to define a simple, reliable method for predicting whether patients with isocitrate dehydrogenase (IDH)-wildtype GB treated with the standard therapy will be short- or long-term survivors, we analyzed the correlation of preoperative blood counts and their combined forms with progression-free survival (PFS) and overall survival (OS) in these patients. Methods: Eighty-five patients with primary IDH-wildtype GB treated with the standard therapy between 2012 and 2019 were analyzed retrospectively. Cox proportional hazards models and Kaplan-Meier analysis were used to investigate the survival function of preoperative hematological parameters. Results: Preoperative high neutrophil-to-lymphocyte ratio (NLR, >2.42), high platelet count (>236 × 10 9 /L), and low red blood cell (RBC) count (≤4.59 × 10 12 /L) were independent prognostic factors for poorer OS ( p = 0.030, p = 0.030, and p = 0.004, respectively). Moreover, a high NLR was an independent prognostic factor for shorter PFS ( p = 0.010). We also found that, like NLR, preoperative high derived NLR (dNLR, >1.89) was of poor prognostic value for both PFS ( p = 0.002) and OS ( p = 0.033). A significant correlation was observed between NLR and dNLR (r = 0.88, p < 0.001), which had a similar prognostic power for OS (NLR: AUC = 0.58; 95% CI: [0.48; 0.68]; dNLR: AUC = 0.62; 95% CI: [0.51; 0.72]). Two scores, one based on preoperative platelet and RBC counts plus NLR and the other on preoperative platelet and RBC counts plus dNLR, were found to be independent prognostic factors for PFS ( p = 0.006 and p = 0.002, respectively) and OS ( p < 0.001 for both scores). Conclusion: Cheap, routinely ordered, preoperative assessments of blood markers, such as NLR, dNLR, RBC, and platelet counts, can predict the survival outcomes of patients with IDH-wildtype GB treated with the standard therapy. |
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فهرسة مساهمة: | Keywords: glioblastoma; hematological markers; prognosis; survival |
تواريخ الأحداث: | Date Created: 20211127 Latest Revision: 20211130 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC8616081 |
DOI: | 10.3390/cancers13225778 |
PMID: | 34830935 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2072-6694 |
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DOI: | 10.3390/cancers13225778 |