دورية أكاديمية
أعرض في EDS

Viral Membrane Fusion Proteins and RNA Sorting Mechanisms for the Molecular Delivery by Exosomes.

التفاصيل البيبلوغرافية
العنوان: Viral Membrane Fusion Proteins and RNA Sorting Mechanisms for the Molecular Delivery by Exosomes.
المؤلفون: Zubarev I; Faculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia.; Laboratory of Intracellular Signaling, Moscow Institute of Physics and Technology, 141701 Moscow, Russia., Vladimirtsev D; Laboratory of Intracellular Signaling, Moscow Institute of Physics and Technology, 141701 Moscow, Russia., Vorontsova M; Faculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia.; The National Medical Research Center for Endocrinology, 117292 Moscow, Russia., Blatov I; Laboratory of Intracellular Signaling, Moscow Institute of Physics and Technology, 141701 Moscow, Russia., Shevchenko K; Institute of Cytology RAS, 194064 St. Petersburg, Russia.; Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, 108819 Moscow, Russia.; Institute of Biomedical Chemistry, 119121 Moscow, Russia., Zvereva S; Laboratory of Intracellular Signaling, Moscow Institute of Physics and Technology, 141701 Moscow, Russia., Lunev EA; Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia., Faizuloev E; I. Mechnikov Research Institute of Vaccines and Sera, 105064 Moscow, Russia., Barlev N; Laboratory of Intracellular Signaling, Moscow Institute of Physics and Technology, 141701 Moscow, Russia.; Institute of Cytology RAS, 194064 St. Petersburg, Russia.; Institute of Biomedical Chemistry, 119121 Moscow, Russia.
المصدر: Cells [Cells] 2021 Nov 05; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 05.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: RNA Transport*, Exosomes/*metabolism , Viral Fusion Proteins/*metabolism , Viral Matrix Proteins/*metabolism, Animals ; Host-Pathogen Interactions ; Humans ; Membrane Fusion
مستخلص: The advancement of precision medicine critically depends on the robustness and specificity of the carriers used for the targeted delivery of effector molecules in the human body. Numerous nanocarriers have been explored in vivo, to ensure the precise delivery of molecular cargos via tissue-specific targeting, including the endocrine part of the pancreas, thyroid, and adrenal glands. However, even after reaching the target organ, the cargo-carrying vehicle needs to enter the cell and then escape lysosomal destruction. Most artificial nanocarriers suffer from intrinsic limitations that prevent them from completing the specific delivery of the cargo. In this respect, extracellular vesicles (EVs) seem to be the natural tool for payload delivery due to their versatility and low toxicity. However, EV-mediated delivery is not selective and is usually short-ranged. By inserting the viral membrane fusion proteins into exosomes, it is possible to increase the efficiency of membrane recognition and also ease the process of membrane fusion. This review describes the molecular details of the viral-assisted interaction between the target cell and EVs. We also discuss the question of the usability of viral fusion proteins in developing extracellular vesicle-based nanocarriers with a higher efficacy of payload delivery. Finally, this review specifically highlights the role of Gag and RNA binding proteins in RNA sorting into EVs.
References: ACS Chem Biol. 2018 Feb 16;13(2):376-382. (PMID: 29019396)
J Clin Invest. 2000 Jun;105(11):1573-87. (PMID: 10841516)
Mol Ther. 2010 Dec;18(12):2048-56. (PMID: 20736929)
Arch Virol. 2018 Jun;163(6):1683-1689. (PMID: 29429034)
Nat Med. 2000 Jul;6(7):769-75. (PMID: 10888925)
Am J Cancer Res. 2018 Jun 01;8(6):916-931. (PMID: 30034931)
Adv Virol. 2012;2012:767694. (PMID: 22888349)
Pharmaceutics. 2018 Nov 06;10(4):. (PMID: 30404188)
Protein Sci. 1992 May;1(5):563-74. (PMID: 1304355)
Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17532-7. (PMID: 18988732)
J Virol. 2011 Nov;85(21):11038-47. (PMID: 21880773)
Emerg Microbes Infect. 2019;8(1):307-326. (PMID: 30866785)
Can J Biochem Cell Biol. 1984 Aug;62(8):752-9. (PMID: 6498591)
J Virol. 2003 Apr;77(8):4794-804. (PMID: 12663786)
Front Oncol. 2020 Jul 30;10:882. (PMID: 32850302)
FEBS Lett. 2015 Dec 21;589(24 Pt B):4071-8. (PMID: 26632510)
Semin Cell Dev Biol. 2017 Jul;67:91-100. (PMID: 28456604)
J Virol. 2019 Jul 17;93(15):. (PMID: 31118251)
Clin Microbiol Rev. 2010 Jul;23(3):577-89. (PMID: 20610824)
Pediatr Res. 2020 Apr;87(5):862-867. (PMID: 31726465)
Sci Rep. 2019 Sep 19;9(1):13601. (PMID: 31537820)
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19057-62. (PMID: 17142321)
Int J Biol Sci. 2017 Sep 21;13(10):1276-1286. (PMID: 29104494)
Clin Microbiol Rev. 2012 Oct;25(4):635-48. (PMID: 23034323)
Microbiol Immunol. 2002;46(3):135-42. (PMID: 12008921)
Adv Mater. 2017 Apr;29(13):. (PMID: 28165174)
Cell. 1993 Sep 24;74(6):1043-51. (PMID: 8402880)
Int J Nanomedicine. 2017 Jul 06;12:4823-4833. (PMID: 28740388)
J Virol. 1990 May;64(5):1920-6. (PMID: 2109098)
Semin Immunol. 2017 Feb;29:49-61. (PMID: 28647227)
APMIS. 2016 Jan-Feb;124(1-2):31-43. (PMID: 26818260)
Cell Microbiol. 2004 May;6(5):401-10. (PMID: 15056211)
Annu Rev Virol. 2014 Nov;1(1):171-89. (PMID: 26958720)
J Mol Biol. 2010 Feb 12;396(1):141-52. (PMID: 19931283)
Curr Opin Virol. 2016 Dec;21:75-80. (PMID: 27596608)
Virology. 2008 Nov 25;381(2):194-202. (PMID: 18834608)
Gut. 2021 Jul 15;:. (PMID: 34266968)
J Biol Chem. 2011 Apr 22;286(16):14383-95. (PMID: 21300796)
Nat Biomed Eng. 2020 Jan;4(1):6-8. (PMID: 31937943)
Sci Rep. 2018 Aug 6;8(1):11784. (PMID: 30082709)
EMBO Rep. 2016 Aug;17(8):1184-203. (PMID: 27402548)
PLoS One. 2016 Nov 10;11(11):e0166474. (PMID: 27832191)
Ann Oncol. 2007 Mar;18(3):485-90. (PMID: 17108150)
J Control Release. 2021 Jul 10;335:584-595. (PMID: 34089793)
J Virol. 2018 Nov 27;92(24):. (PMID: 30282711)
Biophys J. 2016 Mar 8;110(5):1110-24. (PMID: 26958888)
Database (Oxford). 2016 May 30;2016:. (PMID: 27242033)
PLoS One. 2015 Feb 24;10(2):e0118302. (PMID: 25710480)
Science. 1998 Dec 11;282(5396):2079-81. (PMID: 9851928)
J Virol. 1993 Mar;67(3):1365-72. (PMID: 8437221)
Biol Reprod. 2020 Feb 12;102(1):185-198. (PMID: 31318021)
Curr Opin Struct Biol. 2000 Oct;10(5):607-15. (PMID: 11042461)
J Transl Med. 2019 May 28;17(1):178. (PMID: 31138322)
Viruses. 2015 Mar 09;7(3):1079-99. (PMID: 25760140)
Nat Biotechnol. 2011 Apr;29(4):341-5. (PMID: 21423189)
Glycobiology. 2016 Feb;26(2):111-28. (PMID: 26518624)
J Virol. 1995 Apr;69(4):2101-9. (PMID: 7884856)
Nat Rev Genet. 2020 Apr;21(4):255-272. (PMID: 32042148)
J Extracell Vesicles. 2020 Jul 2;9(1):1786967. (PMID: 32944175)
Nature. 2014 Oct 23;514(7523):455-61. (PMID: 25296255)
J Biol Chem. 2013 Jul 5;288(27):20014-33. (PMID: 23661700)
J Virol. 2001 Mar;75(6):2557-65. (PMID: 11222678)
Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12386-90. (PMID: 12218182)
J Immunol. 2011 Jan 1;186(1):73-82. (PMID: 21106852)
J Gen Virol. 2006 May;87(Pt 5):1075-1084. (PMID: 16603507)
Curr Biol. 2020 Jul 6;30(13):R750-R754. (PMID: 32634411)
J Mol Biol. 2011 Jul 22;410(4):609-33. (PMID: 21762803)
Virology. 2014 Apr;454-455:362-70. (PMID: 24530126)
J Cell Sci. 2012 Mar 15;125(Pt 6):1373-82. (PMID: 22499670)
Trends Biochem Sci. 2010 Dec;35(12):699-706. (PMID: 20638285)
J Biol Chem. 2006 Jun 9;281(23):15951-8. (PMID: 16595665)
Exp Ther Med. 2016 Sep;12(3):1639-1644. (PMID: 27602081)
Sci Rep. 2020 May 14;10(1):7939. (PMID: 32409751)
Curr Pharm Des. 2018;24(9):974-982. (PMID: 29376493)
Nature. 2013 Apr 18;496(7445):367-71. (PMID: 23542590)
Nature. 2020 Jul;583(7817):615-619. (PMID: 32494007)
mBio. 2018 Feb 6;9(1):. (PMID: 29437924)
PLoS Pathog. 2020 Sep 21;16(9):e1008883. (PMID: 32956394)
Front Immunol. 2018 Feb 12;9:90. (PMID: 29483904)
Oncogene. 2017 Nov 16;36(46):6462-6471. (PMID: 28759039)
Annu Rev Cell Dev Biol. 2015;31:125-47. (PMID: 26436705)
Nat Commun. 2013;4:2980. (PMID: 24356509)
J Virol. 2005 Dec;79(23):14614-21. (PMID: 16282461)
Medicine (Baltimore). 2018 Mar;97(13):e0203. (PMID: 29595658)
Cell Res. 2014 Jun;24(6):766-9. (PMID: 24710597)
J Extracell Vesicles. 2020 Dec;10(2):e12043. (PMID: 33391635)
PLoS One. 2019 Apr 5;14(4):e0214110. (PMID: 30951545)
Nature. 2015 Nov 19;527(7578):329-35. (PMID: 26524530)
Crit Rev Biochem Mol Biol. 2008 May-Jun;43(3):189-219. (PMID: 18568847)
Nat Commun. 2016 Nov 24;7:13588. (PMID: 27882925)
Cell Commun Signal. 2021 Apr 23;19(1):47. (PMID: 33892745)
Ann Clin Transl Neurol. 2019 Jan 08;6(2):392-396. (PMID: 30847372)
Exp Ther Med. 2020 Jan;19(1):755-761. (PMID: 31885712)
Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9155-61. (PMID: 27432966)
Annu Rev Biochem. 2003;72:175-207. (PMID: 14527322)
Cell Prolif. 2020 Jul;53(7):e12857. (PMID: 32578911)
Science. 2020 Feb 7;367(6478):. (PMID: 32029601)
PLoS One. 2018 Apr 24;13(4):e0195969. (PMID: 29689087)
J Virol. 2015 May;89(10):5200-3. (PMID: 25740980)
J Virol. 2005 May;79(10):5979-87. (PMID: 15857984)
Cell. 1983 Apr;32(4):1069-79. (PMID: 6404557)
Annu Rev Cell Dev Biol. 2014;30:111-39. (PMID: 25000995)
Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6604-E6613. (PMID: 29946031)
Biomaterials. 2018 Aug;174:41-53. (PMID: 29778981)
Int J Mol Med. 2016 Apr;37(4):958-66. (PMID: 26935291)
Int J Biol Markers. 2017 Jul 24;32(3):e278-e283. (PMID: 28085174)
Clinics (Sao Paulo). 2011;66(6):965-72. (PMID: 21808860)
Biomed Res Int. 2015;2015:635792. (PMID: 26380289)
Biotechnol J. 2018 Apr;13(4):e1700443. (PMID: 29274250)
Nature. 2020 Dec;588(7837):308-314. (PMID: 33208938)
J Virol. 1999 Mar;73(3):2270-9. (PMID: 9971810)
Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):E28-E36. (PMID: 27974607)
Cell. 2003 Sep 19;114(6):751-62. (PMID: 14505574)
J Virol. 2005 Sep;79(18):12065-76. (PMID: 16140782)
Bioscience. 2015 Aug 1;65(8):783-797. (PMID: 26955082)
Anal Cell Pathol (Amst). 2018 Jun 20;2018:8389595. (PMID: 30027065)
mBio. 2016 Feb 09;7(1):e02025-15. (PMID: 26861021)
PLoS One. 2017 Aug 15;12(8):e0181711. (PMID: 28809959)
Trends Microbiol. 2017 May;25(5):402-412. (PMID: 28262512)
Circ Res. 2010 Oct 29;107(9):1047-57. (PMID: 21030722)
Cell Rep. 2016 Apr 26;15(4):692-699. (PMID: 27149846)
Nat Cell Biol. 2007 Jun;9(6):654-9. (PMID: 17486113)
J Cell Biol. 2019 May 6;218(5):1436-1451. (PMID: 30936162)
Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6328-33. (PMID: 20304794)
World J Methodol. 2016 Sep 26;6(3):181-6. (PMID: 27679780)
J Cell Sci. 2009 May 15;122(Pt 10):1607-15. (PMID: 19401333)
J Natl Cancer Inst. 2009 Apr 1;101(7):519-32. (PMID: 19318631)
Methods Mol Biol. 2016;1448:249-60. (PMID: 27317186)
PLoS Biol. 2007 Jun;5(6):e158. (PMID: 17550307)
EMBO J. 2010 Apr 7;29(7):1299-311. (PMID: 20168302)
EBioMedicine. 2016 Apr;6:103-113. (PMID: 27211553)
Front Cell Dev Biol. 2021 Apr 12;9:646864. (PMID: 33912560)
Adv Drug Deliv Rev. 2013 Mar;65(3):348-56. (PMID: 22820525)
J Virol. 1997 Jun;71(6):4544-54. (PMID: 9151848)
Proc Natl Acad Sci U S A. 1979 Jun;76(6):2750-4. (PMID: 288063)
Nat Commun. 2020 Mar 13;11(1):1334. (PMID: 32170079)
Science. 2021 Aug 20;373(6557):882-889. (PMID: 34413232)
J Virol. 2004 Jan;78(2):1050-4. (PMID: 14694139)
J Mol Biol. 2012 Mar 30;417(3):224-39. (PMID: 22306406)
Adv Virus Res. 1988;35:1-38. (PMID: 2852891)
Biochim Biophys Acta. 2008 Oct;1780(10):1087-92. (PMID: 18625289)
PLoS Pathog. 2018 Jan 4;14(1):e1006764. (PMID: 29300779)
Adv Virus Res. 2005;64:231-61. (PMID: 16139596)
Microorganisms. 2019 Feb 11;7(2):. (PMID: 30754656)
BMC Cancer. 2009 Jul 07;9:220. (PMID: 19580679)
Blood. 2009 Mar 19;113(12):2732-41. (PMID: 18945959)
PLoS Pathog. 2013 Mar;9(3):e1003249. (PMID: 23555259)
J Virol. 2000 Apr;74(7):3046-57. (PMID: 10708419)
Biophys J. 2007 Apr 15;92(8):L61-3. (PMID: 17277178)
Annu Rev Biochem. 2019 Jun 20;88:487-514. (PMID: 31220978)
PLoS Pathog. 2007 Feb;3(2):e20. (PMID: 17305426)
Cell Rep. 2016 May 3;15(5):978-987. (PMID: 27117408)
Curr Med Chem. 2010;17(8):741-9. (PMID: 20088758)
Cell Host Microbe. 2013 Sep 11;14(3):232-41. (PMID: 24034610)
Int J Mol Sci. 2019 Feb 12;20(3):. (PMID: 30759824)
Sci Adv. 2020 Jul 1;6(27):. (PMID: 32937446)
Eur J Immunol. 2004 Oct;34(10):2834-42. (PMID: 15368299)
ACS Cent Sci. 2016 Sep 28;2(9):621-630. (PMID: 27725960)
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):955-60. (PMID: 11805336)
AIDS. 2003 Jan 3;17(1):33-42. (PMID: 12478067)
Dev Cell. 2019 May 6;49(3):347-360. (PMID: 31063754)
Nat Rev Mol Cell Biol. 2008 Jul;9(7):543-56. (PMID: 18496517)
Int J Mol Sci. 2017 Jul 27;18(8):. (PMID: 28749408)
Annu Rev Biochem. 2000;69:531-69. (PMID: 10966468)
J Biomol Struct Dyn. 2021 May;39(8):3034-3060. (PMID: 32351170)
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7306-11. (PMID: 23589850)
Int J Nanomedicine. 2017 Apr 18;12:3153-3170. (PMID: 28458537)
Front Neurosci. 2017 Feb 27;11:82. (PMID: 28289371)
J Cell Biol. 2020 Oct 5;219(10):. (PMID: 32970791)
Nat Microbiol. 2018 Oct;3(10):1153-1160. (PMID: 30150732)
Cell. 2018 Jan 11;172(1-2):262-274.e11. (PMID: 29328915)
PLoS One. 2011;6(10):e25294. (PMID: 22022385)
Neuro Oncol. 2005 Jul;7(3):236-45. (PMID: 16053698)
J Clin Endocrinol Metab. 2018 Aug 1;103(8):2827-2837. (PMID: 29741675)
Microbiol Mol Biol Rev. 2016 Mar 02;80(2):369-86. (PMID: 26935137)
Oncol Lett. 2018 Jan;15(1):41-47. (PMID: 29285186)
Virology. 2015 May;479-480:498-507. (PMID: 25866377)
Cell Mol Immunol. 2017 May;14(5):465-475. (PMID: 27238466)
Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E8987-E8995. (PMID: 29073095)
Sci Rep. 2018 Jan 10;8(1):387. (PMID: 29321591)
J Cell Biol. 2017 Mar 6;216(3):571-581. (PMID: 28137780)
AIDS Res Hum Retroviruses. 2011 Feb;27(2):167-78. (PMID: 20964480)
Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7724-9. (PMID: 11427703)
Langmuir. 2017 Jan 31;33(4):1051-1059. (PMID: 28059515)
Virus Res. 2019 Jun;266:1-14. (PMID: 30930201)
Viruses. 2019 May 02;11(5):. (PMID: 31052499)
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13109-13. (PMID: 23878230)
Viruses. 2016 Sep 10;8(9):. (PMID: 27626439)
Int J Mol Sci. 2017 Dec 02;18(12):. (PMID: 29207481)
Reproduction. 2016 Nov;152(5):R167-78. (PMID: 27486264)
J Immunol. 2012 Jul 15;189(2):744-54. (PMID: 22711894)
Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10652-7. (PMID: 15998730)
Annu Rev Cell Dev Biol. 2002;18:289-314. (PMID: 12142286)
Elife. 2014 Dec 05;3:e04389. (PMID: 25479384)
PLoS Pathog. 2018 Jul 20;14(7):e1007189. (PMID: 30028877)
PLoS One. 2012;7(11):e50148. (PMID: 23185560)
معلومات مُعتمدة: 75-15-2020-913 Ministry of Science and Higher Education of the Russian Federation
فهرسة مساهمة: Keywords: RNA sorting; extracellular vesicles; fusion protein; target delivery
المشرفين على المادة: 0 (Viral Fusion Proteins)
0 (Viral Matrix Proteins)
تواريخ الأحداث: Date Created: 20211127 Date Completed: 20211221 Latest Revision: 20211221
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8622164
DOI: 10.3390/cells10113043
PMID: 34831268
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells10113043