دورية أكاديمية
أعرض في EDS

Annatto Oil Loaded Nanostructured Lipid Carriers: A Potential New Treatment for Cutaneous Leishmaniasis.

التفاصيل البيبلوغرافية
العنوان: Annatto Oil Loaded Nanostructured Lipid Carriers: A Potential New Treatment for Cutaneous Leishmaniasis.
المؤلفون: Ferreira MA; Laboratory of Drug Development, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Almeida Júnior RF; Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., Onofre TS; Biochemistry and Molecular Biology Department, Federal University of Viçosa (UFV), Viçosa 36570-900, Brazil., Casadei BR; Institute of Physics, University of São Paulo, USP, São Paulo 05508-090, Brazil., Farias KJS; Academic Unit of Biology and Chemistry, Center of Education and Health, Cuité 58175-000, Brazil., Severino P; Institute of Technology and Research (ITP), Aracaju 49010-390, Brazil., de Oliveira Franco CF; Phytotechnical Department, Brazilian Agricultural Research Corporation (EMBRAPA), Brasilia 70770-901, Brazil., Raffin FN; Laboratory of Drug Development, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Lima E Moura TFA; Laboratory of Drug Development, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil., de Melo Barbosa R; Laboratory of Drug Development, Department of Pharmacy, Federal University of Rio Grande do Norte, Natal 59012-570, Brazil.
المصدر: Pharmaceutics [Pharmaceutics] 2021 Nov 11; Vol. 13 (11). Date of Electronic Publication: 2021 Nov 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101534003 Publication Model: Electronic Cited Medium: Print ISSN: 1999-4923 (Print) Linking ISSN: 19994923 NLM ISO Abbreviation: Pharmaceutics Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مستخلص: Annatto ( Bixa orellana L.) is extensively used as food pigment worldwide. Recently, several studies have found it to have healing and antioxidant properties, as well as effective action against leishmaniasis. Therefore, the purpose of this study was to incorporate the oil obtained from annatto seeds into a nanostructured lipid carrier (NLC) and evaluate its physicochemical properties and biological activity against Leishmania major . Nanoparticles were prepared by the fusion-emulsification and ultrasonication method, with the components Synperonic™ PE (PL) as the surfactant, cetyl palmitate (CP) or myristyl myristate (MM) as solid lipids, annatto oil (AO) (2% and 4%, w / w ) as liquid lipid and active ingredient, and ultra-pure water. Physicochemical and biological characterizations were carried out to describe the NLCs, including particle size, polydispersity index (PDI), and zeta potential (ZP) by dynamic light scattering (DLS), encapsulation efficiency (EE%), thermal behavior, X-ray diffraction (XRD), transmission electron microscopy (TEM), Electron Paramagnetic Resonance (EPR), cytotoxicity on BALB/c 3T3 fibroblasts and immortalized human keratinocyte cells, and anti-leishmaniasis activity in vitro. Nanoparticles presented an average diameter of ~200 nm (confirmed by TEM results), a PDI of less than 0.30, ZP between -12.6 and -31.2 mV, and more than 50% of AO encapsulated in NLCs. Thermal analyses demonstrated that the systems were stable at high temperatures with a decrease in crystalline structure due to the presence of AOs (confirmed by XRD). In vitro, the anti-leishmania test displayed good activity in encapsulating AO against L. major . The results indicate that the oily fraction of Bixa orellana L. in NLC systems should be evaluated as a potential therapeutic agent against leishmaniasis.
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فهرسة مساهمة: Keywords: Bixa orellana L.; annatto oil; cutaneous leishmaniasis; lipid nanoparticles; nanostructured lipid carriers (NLC)
تواريخ الأحداث: Date Created: 20211127 Latest Revision: 20231108
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8618414
DOI: 10.3390/pharmaceutics13111912
PMID: 34834327
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4923
DOI:10.3390/pharmaceutics13111912