دورية أكاديمية
أعرض في EDS

Impact of Updating Pharmacogenetic Results: Lessons Learned from the PREDICT Program.

التفاصيل البيبلوغرافية
العنوان: Impact of Updating Pharmacogenetic Results: Lessons Learned from the PREDICT Program.
المؤلفون: Liu M; Department of Pharmacy, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Van Driest SL; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Vnencak-Jones CL; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Saucier LAG; Vanderbilt Institute for Clinical & Translational Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Roland BP; Vanderbilt Institute for Clinical & Translational Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Gatto CL; Vanderbilt Institute for Clinical & Translational Research, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Just SL; Health IT Decision Support and Knowledge Engineering, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Weitkamp AO; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA., Peterson JF; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA.; Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
المصدر: Journal of personalized medicine [J Pers Med] 2021 Oct 20; Vol. 11 (11). Date of Electronic Publication: 2021 Oct 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, 2011-
مستخلص: Pharmacogenomic (PGx) evidence for selective serotonin reuptake inhibitors (SSRIs) continues to evolve. For sites offering testing, maintaining up-to-date interpretations and implementing new clinical decision support (CDS) driven by existing results creates practical and technical challenges. Vanderbilt University Medical Center initiated panel testing in 2010, added CYP2D6 testing in 2017, and released CDS for SSRIs in 2020. We systematically reinterpreted historic CYP2C19 and CYP2D6 genotypes to update phenotypes to current nomenclature and to launch provider CDS and patient-oriented content for SSRIs. Chart review was conducted to identify and recontact providers caring for patients with current SSRI therapy and new actionable recommendations. A total of 15,619 patients' PGx results were reprocessed. Of the non-deceased patients reprocessed, 21% ( n = 3278) resulted in CYP2C19 *1/*17 reinterpretations. Among 289 patients with an actionable recommendation and SSRI medication prescription, 31.8% ( n = 92) did not necessitate contact of a clinician, while 43.2% ( n = 125) resulted in clinician contacted, and for 25% ( n = 72) no appropriate clinician was able to be identified. Maintenance of up-to-date interpretations and recommendations for PGx results over the lifetime of a patient requires continuous effort. Reprocessing is a key strategy for maintenance and expansion of PGx content to be periodically considered and implemented.
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معلومات مُعتمدة: UL1TR002243 United States TR NCATS NIH HHS; U01HG010232 United States HG NHGRI NIH HHS; U01HG007253 United States HG NHGRI NIH HHS
فهرسة مساهمة: Keywords: SSRIs; personalized medicine; pharmacogenetics; pharmacogenomics; precision medicine; reinterpretation; reprocessing
تواريخ الأحداث: Date Created: 20211127 Latest Revision: 20211130
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8617828
DOI: 10.3390/jpm11111051
PMID: 34834403
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4426
DOI:10.3390/jpm11111051