دورية أكاديمية
Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast.
| العنوان: | Association between Maternal Non-Coding Interferon-λ Polymorphisms and Congenital Zika Syndrome in a Cohort from Brazilian Northeast. |
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| المؤلفون: | Rossi ÁD; Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil., Faucz FR; Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA., Melo A; Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande 58406-115, Brazil., de Azevedo GS; Instituto de Pesquisa Professor Joaquim Amorim Neto (IPESQ), Campina Grande 58406-115, Brazil., Pezzuto P; Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil., Bezerra OCL; Laboratório de Hanseníase, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21040-900, Brazil., Manta FSN; Laboratório de Hanseníase, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21040-900, Brazil., Azamor T; Laboratório de Hanseníase, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21040-900, Brazil., Schamber-Reis BLF; Faculdade de Ciências Médicas de Campina Grande, Núcleo de Genética Médica, Centro Universitário UniFacisa, Campina Grande 58408-326, Brazil., Tanuri A; Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil., Moraes MO; Laboratório de Hanseníase, Instituto Oswaldo Cruz Fiocruz, Rio de Janeiro 21040-900, Brazil., Aguiar RS; Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil.; Laboratório de Biologia Integrativa, Departamento de Genética, Ecologia e Evolução, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, Brazil., Stratakis CA; Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20814, USA., Cardoso CC; Laboratório de Virologia Molecular, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-902, Brazil. |
| المصدر: | Viruses [Viruses] 2021 Nov 10; Vol. 13 (11). Date of Electronic Publication: 2021 Nov 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مواضيع طبية MeSH: | Interferons/*genetics , Pregnancy Complications, Infectious/*genetics , Zika Virus Infection/*congenital , Zika Virus Infection/*genetics, Alleles ; Brazil ; Case-Control Studies ; Female ; Genetic Association Studies ; Genetic Predisposition to Disease ; Genotype ; Humans ; Polymorphism, Single Nucleotide ; Pregnancy ; Zika Virus |
| مستخلص: | Congenital Zika syndrome (CZS) is characterized by a diverse group of congenital malformations induced by ZIKV infection during pregnancy. Type III interferons have been associated with placental immunity against ZIKV and restriction of vertical transmission in mice, and non-coding single-nucleotide polymorphisms (SNPs) on these genes are well known to influence susceptibility to other viral infections. However, their effect on ZIKV pathogenesis has not yet been explored. To investigate whether maternal non-coding SNPs at IFNL genes are associated with CZS, 52 women infected with ZIKV during pregnancy were enrolled in a case-control association study. A total of 28 women were classified as cases and 24 as controls based on the presence or absence of CZS in their infants, and seven Interferon-λ non-coding SNPs (rs12980275, rs8099917, rs4803217, rs4803219, rs8119886, rs368234815, rs12979860) were genotyped. The results of logistic regression analyses show an association between the G allele at rs8099917 and increased susceptibility to CZS under a log-additive model ( |
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| فهرسة مساهمة: | Keywords: Zika; congenital Zika syndrome; genetic susceptibility; polymorphism; type III interferon |
| المشرفين على المادة: | 0 (interferon-lambda, human) 9008-11-1 (Interferons) |
| تواريخ الأحداث: | Date Created: 20211127 Date Completed: 20220214 Latest Revision: 20240404 |
| رمز التحديث: | 20240404 |
| مُعرف محوري في PubMed: | PMC8622836 |
| DOI: | 10.3390/v13112253 |
| PMID: | 34835060 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1999-4915 |
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| DOI: | 10.3390/v13112253 |