دورية أكاديمية
أعرض في EDS

Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leoneans.

التفاصيل البيبلوغرافية
العنوان: Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leoneans.
المؤلفون: Borrega R; Zalgen Labs, LCC, Germantown, MD 20876, USA., Nelson DKS; Zalgen Labs, LCC, Broomfield, CO 80045, USA., Koval AP; Zalgen Labs, LCC, Germantown, MD 20876, USA., Bond NG; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Heinrich ML; Zalgen Labs, LCC, Germantown, MD 20876, USA., Rowland MM; Zalgen Labs, LCC, Germantown, MD 20876, USA., Lathigra R; Zalgen Labs, LCC, Germantown, MD 20876, USA., Bush DJ; Zalgen Labs, LCC, Broomfield, CO 80045, USA., Aimukanova I; Zalgen Labs, LCC, Broomfield, CO 80045, USA., Phinney WN; Zalgen Labs, LCC, Broomfield, CO 80045, USA., Koval SA; Zalgen Labs, LCC, Germantown, MD 20876, USA., Hoffmann AR; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Smither AR; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Bell-Kareem AR; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Melnik LI; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Genemaras KJ; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Bioinnovation Program, Tulane University, New Orleans, LA 70118, USA., Chao K; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Bioinnovation Program, Tulane University, New Orleans, LA 70118, USA., Snarski P; Heart and Vascular Institute, John W. Deming Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Department of Physiology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Melton AB; Department of Microbiology, Tulane National Primate Research Center, Covington, LA 70433, USA., Harrell JE; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Smira AA; Department of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Elliott DH; Department of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Rouelle JA; Department of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Sabino-Santos G Jr; Department of Tropical Medicine, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.; Centre for Virology Research, Ribeirão Preto Medical School, University of Sao Paulo, Ribeirao Preto 14049-900, SP, Brazil., Drouin AC; Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Momoh M; Eastern Polytechnic Institute, Kenema, Sierra Leone.; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone., Sandi JD; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone., Goba A; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone., Samuels RJ; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone., Kanneh L; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone., Gbakie M; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone., Branco ZL; Zalgen Labs, LCC, Germantown, MD 20876, USA., Shaffer JG; Department of Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA., Schieffelin JS; Department of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA.; Department of Internal Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Robinson JE; Department of Pediatrics, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Fusco DN; Department of Medicine, School of Medicine, Tulane University, New Orleans, LA 70112, USA., Sabeti PC; Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA 02115, USA.; Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA.; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02115, USA., Andersen KG; Department of Immunology and Microbial Science, Scripps Research, La Jolla, CA 92037, USA.; Scripps Research Translational Institute, La Jolla, CA 92037, USA., Grant DS; Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone.; Ministry of Health and Sanitation, Freetown, Sierra Leone., Boisen ML; Zalgen Labs, LCC, Broomfield, CO 80045, USA., Branco LM; Zalgen Labs, LCC, Germantown, MD 20876, USA., Garry RF; Zalgen Labs, LCC, Germantown, MD 20876, USA.; Zalgen Labs, LCC, Broomfield, CO 80045, USA.; Department of Microbiology and Immunology, School of Medicine, Tulane University, New Orleans, LA 70112, USA.
المصدر: Viruses [Viruses] 2021 Nov 21; Vol. 13 (11). Date of Electronic Publication: 2021 Nov 21.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Antibodies, Viral/*immunology , COVID-19/*immunology , Middle East Respiratory Syndrome Coronavirus/*immunology , SARS-CoV-2/*immunology, Age Distribution ; Alphacoronavirus/immunology ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/blood ; Antigens, Viral/immunology ; Betacoronavirus/immunology ; Blood Donors ; Coronavirus Nucleocapsid Proteins/immunology ; Cross Protection ; Cross Reactions ; Epitopes ; Female ; Humans ; Male ; Phosphoproteins/immunology ; Sierra Leone ; United States ; Viral Pseudotyping
مستخلص: Many countries in sub-Saharan Africa have experienced lower COVID-19 caseloads and fewer deaths than countries in other regions worldwide. Under-reporting of cases and a younger population could partly account for these differences, but pre-existing immunity to coronaviruses is another potential factor. Blood samples from Sierra Leonean Lassa fever and Ebola survivors and their contacts collected before the first reported COVID-19 cases were assessed using enzyme-linked immunosorbent assays for the presence of antibodies binding to proteins of coronaviruses that infect humans. Results were compared to COVID-19 subjects and healthy blood donors from the United States. Prior to the pandemic, Sierra Leoneans had more frequent exposures than Americans to coronaviruses with epitopes that cross-react with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), SARS-CoV, and Middle Eastern respiratory syndrome coronavirus (MERS-CoV). The percentage of Sierra Leoneans with antibodies reacting to seasonal coronaviruses was also higher than for American blood donors. Serological responses to coronaviruses by Sierra Leoneans did not differ by age or sex. Approximately a quarter of Sierra Leonian pre-pandemic blood samples had neutralizing antibodies against SARS-CoV-2 pseudovirus, while about a third neutralized MERS-CoV pseudovirus. Prior exposures to coronaviruses that induce cross-protective immunity may contribute to reduced COVID-19 cases and deaths in Sierra Leone.
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معلومات مُعتمدة: U19 AI135995 United States AI NIAID NIH HHS; 1R01 AI123535 United States NH NIH HHS; U54 CA260581 United States CA NCI NIH HHS; U19AI135995 and U19AI151812, and 1R01AI123535 United States NH NIH HHS; U01 AI151812 United States AI NIAID NIH HHS; U19 AI151812 United States NH NIH HHS
فهرسة مساهمة: Keywords: COVID-19 caseloads and deaths; Middle Eastern respiratory syndrome coronavirus; enzyme-linked immunosorbent assays; pre-existing immunity to coronaviruses; pseudovirus neutralizing antibodies; recombinant antigens; severe acute respiratory syndrome coronavirus-2; sub-Saharan Africa
المشرفين على المادة: 0 (Antibodies, Neutralizing)
0 (Antibodies, Viral)
0 (Antigens, Viral)
0 (Coronavirus Nucleocapsid Proteins)
0 (Epitopes)
0 (Phosphoproteins)
0 (nucleocapsid phosphoprotein, SARS-CoV-2)
تواريخ الأحداث: Date Created: 20211127 Date Completed: 20211210 Latest Revision: 20231028
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8625389
DOI: 10.3390/v13112325
PMID: 34835131
قاعدة البيانات: MEDLINE
الوصف
تدمد:1999-4915
DOI:10.3390/v13112325