دورية أكاديمية
أعرض في EDS

Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states.

التفاصيل البيبلوغرافية
العنوان: Synaptic protein interaction networks encode experience by assuming stimulus-specific and brain-region-specific states.
المؤلفون: Lautz JD; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Tsegay KB; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Zhu Z; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Gniffke EP; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA., Welsh JP; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA., Smith SEP; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Pediatrics, University of Washington, Seattle, WA, USA; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA. Electronic address: seps@uw.edu.
المصدر: Cell reports [Cell Rep] 2021 Nov 30; Vol. 37 (9), pp. 110076.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Protein Interaction Maps*, Blinking/*drug effects , Brain/*metabolism , Methoxyhydroxyphenylglycol/*analogs & derivatives , N-Methylaspartate/*pharmacology , Proteome/*metabolism , Synapses/*metabolism, Animals ; Brain/drug effects ; Conditioning, Eyelid ; Excitatory Amino Acid Agonists/pharmacology ; Female ; Male ; Methoxyhydroxyphenylglycol/pharmacology ; Mice ; Neuronal Plasticity ; Proteome/analysis ; Synapses/drug effects
مستخلص: A core network of widely expressed proteins within the glutamatergic post-synapse mediates activity-dependent synaptic plasticity throughout the brain, but the specific proteomic composition of synapses differs between brain regions. Here, we address the question, how does proteomic composition affect activity-dependent protein-protein interaction networks (PINs) downstream of synaptic activity? Using quantitative multiplex co-immunoprecipitation, we compare the PIN response of in vivo or ex vivo neurons derived from different brain regions to activation by different agonists or different forms of eyeblink conditioning. We report that PINs discriminate between incoming stimuli using differential kinetics of overlapping and non-overlapping PIN parameters. Further, these "molecular logic rules" differ by brain region. We conclude that although the PIN of the glutamatergic post-synapse is expressed widely throughout the brain, its activity-dependent dynamics show remarkable stimulus-specific and brain-region-specific diversity. This diversity may help explain the challenges in developing molecule-specific drug therapies for neurological disorders.
Competing Interests: Conflict of interest The authors declare no competing interests.
(Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: P50 HD103524 United States HD NICHD NIH HHS; R01 MH113545 United States MH NIMH NIH HHS; R01 MH121487 United States MH NIMH NIH HHS; R01 NS031224 United States NS NINDS NIH HHS
فهرسة مساهمة: Keywords: PiSCES; eyeblink conditioning; protein-protein interaction; signaling
المشرفين على المادة: 0 (Excitatory Amino Acid Agonists)
0 (Proteome)
534-82-7 (Methoxyhydroxyphenylglycol)
6384-92-5 (N-Methylaspartate)
UEH9K539KJ (3,4-dihydroxyphenylglycol)
تواريخ الأحداث: Date Created: 20211201 Date Completed: 20220215 Latest Revision: 20231105
رمز التحديث: 20231105
مُعرف محوري في PubMed: PMC8722361
DOI: 10.1016/j.celrep.2021.110076
PMID: 34852231
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2021.110076