The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis.
| العنوان: | The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis. |
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| المؤلفون: | Dolens EDS; Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba, Brazil.; University of Western São Paulo (UNOESTE), Presidente Prudente, Brazil., Dourado MR; Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, Brazil., Almangush A; Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.; Department of Pathology, University of Helsinki, Helsinki, Finland., Salo TA; Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki, Finland.; Department of Pathology, University of Helsinki, Helsinki, Finland.; Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, University of Oulu and Oulu University Hospital, Oulu, Finland., Gurgel Rocha CA; Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Brazil.; Department of Propaedeutics, School of Dentistry, Federal University of Bahia, Bahia, Brazil., da Silva SD; Department of Otolaryngology Head and Neck Surgery, Sir Mortimer B. Davis-Jewish General Hospital, Faculty of Medicine, McGill University, Montreal, QC, Canada.; Segal Cancer Centre and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, Department of Experimental Medicine, Faculty of Medicine, McGill University, Montreal, QC, Canada., Brennan PA; Department of Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, United Kingdom., Coletta RD; Graduate Program in Oral Biology, School of Dentistry, University of Campinas, Piracicaba, Brazil.; Department of Oral Diagnosis, School of Dentistry, University of Campinas, Piracicaba, Brazil. |
| المصدر: | Frontiers in oncology [Front Oncol] 2021 Nov 10; Vol. 11, pp. 784924. Date of Electronic Publication: 2021 Nov 10 (Print Publication: 2021). |
| نوع المنشور: | Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مستخلص: | Objective: Over many decades, studies on histopathological features have not only presented high-level evidence of contribution for treatment directions and prognosis of oral squamous cell carcinoma (OSCC) but also provided inconsistencies, making clinical application difficult. The 8th TNM staging system of OSCC has acknowledged the importance of some histopathological features, by incorporating depth of invasion (DOI) to T category and extranodal extension (ENE) to N category. The aim of this systematic review with meta-analysis is to determine the most clinically relevant histopathological features for risk assessment and treatment planning of OSCC and to elucidate gaps in the literature. Methods: A systematic review was conducted using PRISMA guidelines, and the eligibility criteria were based on population, exposure, comparison, outcome, and study type (PECOS). PubMed, Cochrane, Scopus, and Web of Science were searched for articles exploring the impact of histopathological features on OSCC outcomes with Cox multivariate analysis. Pooled data were subjected to an inverse variance method with random effects or fixed effect model, and the risk of bias was evaluated using quality in prognosis studies (QUIPS). Quality of evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria. Results: The study included 172 articles published from 1999 to 2021. Meta-analyses confirmed the prognostic potential of DOI, ENE, perineural invasion, lymphovascular invasion, and involvement of the surgical margins and brought promising results for the association of bone invasion, tumor thickness, and pattern of invasion with increased risk for poor survival. Although with a small number of studies, the results also revealed a clinical significance of tumor budding and tumor-stroma ratio on predicted survival of patients with OSCC. Most of the studies were considered with low or moderate risk of bias, and the certainty in evidence varied from very low to high. Conclusion: Our results confirm the potential prognostic usefulness of many histopathological features and highlight the promising results of others; however, further studies are advised to apply consistent designs, filling in the literature gaps to the pertinence of histopathological markers for OSCC prognosis. Systematic Review Registration: International Prospective Register of Systematic Reviews (PROSPERO), identifier CRD42020219630. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Dolens, Dourado, Almangush, Salo, Gurgel Rocha, da Silva, Brennan and Coletta.) |
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| فهرسة مساهمة: | Keywords: histopathological markers; meta-analysis; oral cancer; prognosis; systematic review |
| تواريخ الأحداث: | Date Created: 20211203 Latest Revision: 20240404 |
| رمز التحديث: | 20240404 |
| مُعرف محوري في PubMed: | PMC8631280 |
| DOI: | 10.3389/fonc.2021.784924 |
| PMID: | 34858861 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2234-943X |
|---|---|
| DOI: | 10.3389/fonc.2021.784924 |