دورية أكاديمية
أعرض في EDS

Association Between Ov16 Seropositivity and Neurocognitive Performance Among Children in Rural Cameroon: a Pilot Study.

التفاصيل البيبلوغرافية
العنوان: Association Between Ov16 Seropositivity and Neurocognitive Performance Among Children in Rural Cameroon: a Pilot Study.
المؤلفون: Siewe Fodjo JN; Global Health Institute, University of Antwerp, Antwerp, Belgium.; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon., Njamnshi WY; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon.; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Ngarka L; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon.; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.; Department of Neurology, Yaoundé Central Hospital, Yaoundé, Cameroon., Nfor LN; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon.; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.; Department of Neurology, Yaoundé Central Hospital, Yaoundé, Cameroon., Ayuk C; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Mundih NN; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Ekwoge HT; Buea Regional Hospital, Buea, Cameroon.; HILPharma Organization, Yaoundé, Cameroon., Nganchfu K; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Njamnshi KG; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Yerema R; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Ngoundjou P; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Awasume E; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Ashu G; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon., Tabah EN; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.; Faculty of Medicine & Pharmaceutical Sciences, The University of Dschang, Dschang, Cameroon.; Ministry of Public Health, Yaoundé, Cameroon., Colebunders R; Global Health Institute, University of Antwerp, Antwerp, Belgium., Njamnshi AK; Brain Research Africa Initiative (BRAIN), Yaoundé, Cameroon.; Neuroscience Lab, Faculty of Medicine & Biomedical Sciences, The University of Yaoundé I, Yaoundé, Cameroon.; Department of Neurology, Yaoundé Central Hospital, Yaoundé, Cameroon.
المصدر: Journal of pediatric neuropsychology [J Pediatr Neuropsychol] 2021; Vol. 7 (4), pp. 192-202. Date of Electronic Publication: 2021 Sep 07.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101700073 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2199-2681 (Print) Linking ISSN: 21992681 NLM ISO Abbreviation: J Pediatr Neuropsychol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cham] : Springer International Publishing, [2015]-
مستخلص: Infection with Onchocerca volvulus was recently reported to increase the risk for epilepsy in Cameroonian children. We investigated whether infection with O. volvulus may alter the cognitive function of children who may or may not develop epilepsy later in their lifetime. Using rapid diagnostic tests, we determined the presence of Ov16 antibodies in 209 school-aged children without epilepsy recruited from three Cameroonian villages, as a proxy for onchocerciasis exposure. In addition, the neurocognitive performance of these children was assessed using a battery of validated tools. Participants were aged 6-16 years, and 46.4% were Ov16 seropositive. Upon standardizing age-specific neurocognitive scores and investigating predictors of neurocognitive performance using multiple linear regression models (adjusted for gender, education level, previous ivermectin use, and anthropometric parameters), we found that being Ov16-positive was significantly associated with reduced semantic verbal fluency (estimate -0.38; 95% confidence interval -0.65 to -0.11; p  = 0.006) and lower scores on the International HIV Dementia Scale (estimate -0.31; confidence interval -0.56 to -0.04; p  = 0.025). Furthermore, an increasing frequency of past ivermectin use was associated with increased neurocognitive scores. Our findings suggest that exposure to O. volvulus may affect neurocognitive performance of children.
Supplementary Information: The online version contains supplementary material available at 10.1007/s40817-021-00111-z.
Competing Interests: Conflict of InterestThe authors declare no competing interests.
(© The Author(s) 2021, corrected publication 2021.)
References: PLoS Negl Trop Dis. 2009 Jun 16;3(6):e461. (PMID: 19529767)
J Acquir Immune Defic Syndr. 2008 Dec 1;49(4):393-7. (PMID: 19186351)
AIDS. 2005 Sep 2;19(13):1367-74. (PMID: 16103767)
Epilepsy Behav. 2019 Jan;90:70-78. (PMID: 30513438)
Trans R Soc Trop Med Hyg. 2002 Sep-Oct;96(5):537-41. (PMID: 12474484)
Epileptic Disord. 2020 Jun 1;22(3):301-308. (PMID: 32540799)
Bull World Health Organ. 2007 Sep;85(9):660-7. (PMID: 18026621)
Child Neuropsychol. 2013;19(2):143-60. (PMID: 22176123)
East Afr Med J. 1950 Sep;27(9):339-59. (PMID: 14793447)
Lancet. 1998 May 2;351(9112):1341-6. (PMID: 9643811)
Child Neuropsychol. 2010;16(1):1-19. (PMID: 19370432)
Epileptic Disord. 2018 Dec 1;20(6):508-516. (PMID: 30530420)
Ann Trop Med Parasitol. 1997 Jan;91(1):79-86. (PMID: 9093432)
AIDS Res Treat. 2012;2012:581531. (PMID: 23050130)
Front Psychol. 2019 Jan 09;9:2735. (PMID: 30687186)
Parasit Vectors. 2016 Jun 13;9(1):338. (PMID: 27296630)
Dement Neuropsychol. 2017 Jul-Sep;11(3):287-296. (PMID: 29213526)
Am J Trop Med Hyg. 2011 Aug;85(2):333-40. (PMID: 21813856)
Epilepsy Behav. 2020 Nov;112:107437. (PMID: 32920377)
Infect Dis Poverty. 2019 Feb 10;8(1):11. (PMID: 30738437)
Trends Parasitol. 2018 Mar;34(3):208-216. (PMID: 29288080)
Seizure. 2018 Nov;62:108-115. (PMID: 30340162)
Lancet Infect Dis. 2018 Nov;18(11):1278-1286. (PMID: 30268645)
BMJ Open. 2014 Nov 14;4(11):e006476. (PMID: 25398677)
Trop Med Int Health. 2006 Apr;11(4):386-97. (PMID: 16553922)
J Infect Dis. 2000 Dec;182(6):1796-9. (PMID: 11069258)
Int Health. 2018 Mar 1;10(suppl_1):i40-i48. (PMID: 29471342)
Open Forum Infect Dis. 2020 Jun 02;7(6):ofaa206. (PMID: 32587878)
N Engl J Med. 2017 Nov 23;377(21):2044-2052. (PMID: 29116890)
PLoS Negl Trop Dis. 2019 Jul 17;13(7):e0007300. (PMID: 31314757)
Lancet. 1997 Jul 5;350(9070):18-22. (PMID: 9217715)
PLoS Negl Trop Dis. 2017 Feb 9;11(2):e0005201. (PMID: 28182652)
فهرسة مساهمة: Keywords: Cameroon; Neurocognitive assessment; Onchocerciasis-associated epilepsy; Ov16
تواريخ الأحداث: Date Created: 20211206 Latest Revision: 20220428
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8602181
DOI: 10.1007/s40817-021-00111-z
PMID: 34868828
قاعدة البيانات: MEDLINE
الوصف
تدمد:2199-2681
DOI:10.1007/s40817-021-00111-z